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MSMSfinal_DEM.xlsx 里面包含每个比对组别鉴定的差异代谢物的统计信息和汇总表格。

本实验中所得差异代谢物的统计分析结果见下表：

A vs C
B vs C
A vs B vs C
A vs B

	VIP	mean_A	sd_A	mean_C	sd_C	Fold Change_A/C	log2(FC_A/C)	p.value	FDR
Acetoacetic acid	1.271	371667297.266	4897743.120	402907943.003	13479807.471	0.922	-0.116	0.005	0.014
2-Ketobutyric acid	1.451	190479764.127	9845064.983	112563446.849	6080935.778	1.692	0.759	0.005	0.014
gamma-Aminobutyric acid	1.413	6134107096.984	175699794.742	4717103949.548	283678902.459	1.300	0.379	0.005	0.014
2-Phenylethanol	1.405	17492799.788	7466387.994	48339088.423	2156420.712	0.362	-1.466	0.005	0.014
Cytosine	1.459	857359487.287	35131051.471	1299864608.381	42315901.201	0.660	-0.600	0.005	0.014
Maleamate	1.413	87524528.321	5847344.733	61176481.187	2149246.120	1.431	0.517	0.005	0.014
Indole	1.372	214214492.004	15309622.725	269043647.879	7232286.445	0.796	-0.329	0.005	0.014
L-Threonine	1.442	296292136.643	10274379.320	398916462.877	14217174.632	0.743	-0.429	0.005	0.014
4-Hydroxybenzoic acid	1.473	31381263.687	1438147.327	3183104.032	612528.715	9.859	3.301	0.005	0.014
Tyrosol	1.469	261552009.476	13260891.568	78878028.222	7312406.582	3.316	1.729	0.005	0.014
Thymine	1.392	36273344.549	6424790.158	87713307.469	12599998.433	0.414	-1.274	0.005	0.014
Oxoglutaric acid	1.458	33220061.494	1857854.925	16627164.058	922218.870	1.998	0.999	0.005	0.014
Pipecolic acid	1.469	1841602801.178	53556257.479	1130694691.193	26074471.897	1.629	0.704	0.005	0.014
N-Acetylputrescine	1.452	510820622.366	26490211.699	302331812.179	14709350.213	1.690	0.757	0.005	0.014
3-Methylindole	1.405	172111772.217	11717656.893	236253412.114	11065042.763	0.729	-0.457	0.005	0.014
L-Asparagine	1.406	292727493.851	12531177.304	195278952.446	20802003.153	1.499	0.584	0.005	0.014
L-Aspartic acid	1.459	791109804.234	26892389.783	536501006.845	15441516.496	1.475	0.560	0.005	0.014
Chavicol	1.012	53168122.443	24886269.990	21053039.979	8995571.553	2.525	1.337	0.005	0.014
2-Phenylacetamide	1.466	809550790.752	20503117.984	513483783.712	19045527.409	1.577	0.657	0.005	0.014
Hypoxanthine	1.471	181712662.544	7279573.556	68759339.557	3229916.876	2.643	1.402	0.005	0.014
4-Hydroxyphenylacetaldehyde	1.138	59674674.962	33208263.481	7757606.324	2394433.737	7.692	2.943	0.005	0.014
Tyramine	1.469	80909162.990	4568444.484	23442548.911	1227764.758	3.451	1.787	0.005	0.014
Acetylphosphate	1.169	113189493.181	42779446.979	34274508.451	19975739.015	3.302	1.724	0.005	0.014
6-Hydroxynicotinic acid	1.472	76639414.798	2633005.384	30145103.296	1552858.270	2.542	1.346	0.005	0.014
Ectoine	1.469	178433924.823	12688313.703	24282298.902	2305842.922	7.348	2.877	0.005	0.014
2-Dehydropantoate	1.386	449776389.362	30604809.916	585631009.211	23939545.031	0.768	-0.381	0.005	0.014
Coumarin	1.461	151691341.020	6579799.049	91673409.280	1918256.985	1.655	0.727	0.005	0.014
L-Glutamine	1.452	2119735836.599	113628205.775	1226092202.748	62977857.075	1.729	0.790	0.005	0.014
L-Lysine	1.450	719165085.769	27133936.544	490083020.475	21199356.564	1.467	0.553	0.005	0.014
trans-Cinnamate	1.247	153735938.424	7426044.757	133828117.878	6393636.389	1.149	0.200	0.005	0.014
(+)-(S)-Carvone	1.146	18403874.796	4832325.498	10111655.858	1976759.186	1.820	0.864	0.005	0.014
Guanine	1.313	1028235026.839	55110542.015	1206368441.684	44818987.986	0.852	-0.231	0.005	0.014
D-Arabitol	1.315	35221771.743	3876362.961	48806879.341	3745289.643	0.722	-0.471	0.005	0.014
Pulegone	1.473	78628685.658	1865345.068	141173015.185	2988159.818	0.557	-0.844	0.005	0.014
Aminoadipic acid	1.435	59812806.502	5881778.639	107787356.903	6965782.760	0.555	-0.850	0.005	0.014
Anabasine	1.265	36011329.513	962136.354	40236443.664	1723062.385	0.895	-0.160	0.005	0.014
2-Hydroxy-2-ethylsuccinic acid	1.436	51519725.978	3733339.357	31270680.577	635716.004	1.647	0.720	0.005	0.014
Alpha-D-Glucose	1.206	1291457059.125	98116498.905	1072200410.433	69518620.491	1.204	0.268	0.005	0.014
Nicotine	1.411	51151178.588	3217865.540	36031224.751	1681495.920	1.420	0.506	0.005	0.014
4-Hydroxycinnamic acid	1.453	20893904.631	1643473.682	7875213.387	823536.014	2.653	1.408	0.005	0.014
L-Methionine S-oxide	1.466	465475943.410	16306041.069	259595578.443	11094768.747	1.793	0.842	0.005	0.014
Formylanthranilic acid	1.442	20449566.978	233068.204	16035399.685	718416.763	1.275	0.351	0.005	0.014
Normetanephrine	1.011	109520962.580	41622690.690	58856613.881	3767609.445	1.861	0.896	0.005	0.014
L-4-Hydroxyphenylglycine	1.466	651299906.848	20146128.351	390482628.868	14547400.668	1.668	0.738	0.005	0.014
3-Methoxyanthranilate	1.440	105215185.620	7051606.738	160048205.262	6606550.183	0.657	-0.605	0.005	0.014
(1S,4R)-1-Hydroxy-2-oxolimonene	1.426	24532332.501	2277971.359	4854411.607	3431670.837	5.054	2.337	0.005	0.014
Pyridoxine	1.470	46488227.549	2458846.142	95439919.112	2680743.719	0.487	-1.038	0.005	0.014
Serotonin	1.463	4462011.106	603166.853	15578757.974	1025017.040	0.286	-1.804	0.005	0.014
Kanosamine	1.379	51969994.567	3689924.862	37790780.787	2030627.970	1.375	0.460	0.005	0.014
2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid	1.338	61986385.205	4940034.241	78214014.321	3195074.225	0.793	-0.335	0.005	0.014
myo-Inositol	1.456	55784888.493	3057971.526	103742168.177	5544635.215	0.538	-0.895	0.005	0.014
L-Tyrosine	1.469	3000721799.312	86106556.148	1841414674.705	37824118.803	1.630	0.705	0.005	0.014
Phosphorylcholine	1.281	401348974.038	29196972.930	543020965.109	55847536.407	0.739	-0.436	0.005	0.014
Diaminopimelic acid	1.442	58185150.542	2231228.828	74883979.765	1806525.989	0.777	-0.364	0.005	0.014
2-Amino-2-deoxy-D-gluconate	1.319	10963643.930	2287927.828	18375493.012	1765851.791	0.597	-0.745	0.005	0.014
L-Dopa	1.397	19743322.575	881663.846	14607725.456	1043702.145	1.352	0.435	0.005	0.014
Spermine	1.472	7257139.129	819059.903	28704081.689	1117830.474	0.253	-1.984	0.005	0.014
3-[(1-Carboxyvinyl)oxy]benzoate	1.341	100893053.148	34369957.524	4937028.271	1175549.057	20.436	4.353	0.005	0.014
(+)-7-Isojasmonic acid	1.436	157774684.634	10136912.563	82020600.706	10002104.437	1.924	0.944	0.005	0.014
Dethiobiotin	1.367	80112749.234	3765239.659	60397161.082	5006477.864	1.326	0.408	0.005	0.014
4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine	1.199	34902446.045	14702669.739	99310081.017	32784949.740	0.351	-1.509	0.005	0.014
Pantothenic acid	1.471	257003147.531	8875680.725	118856177.445	4559774.206	2.162	1.113	0.005	0.014
Pyrimidodiazepine	1.448	57217199.199	2655812.503	85688152.213	3584202.762	0.668	-0.583	0.005	0.014
2-trans,6-trans-Farnesal	1.336	16778236.607	1321166.674	22797198.075	1755367.851	0.736	-0.442	0.005	0.014
N-Acetyl-D-glucosamine	1.386	117871600.218	16074927.157	205015415.740	18968437.328	0.575	-0.799	0.005	0.014
Traumatic Acid	1.249	71136597.569	2800988.249	63652249.378	2358258.958	1.118	0.160	0.005	0.014
N-Acetyl-L-2-amino-6-oxopimelate	1.169	31369502.028	4509584.353	23549663.775	1247747.605	1.332	0.414	0.005	0.014
Abscisic alcohol	1.115	26586511.280	10421977.525	10954124.099	1514535.429	2.427	1.279	0.005	0.014
L-Formylkynurenine	1.422	217766716.814	8958112.246	62346627.989	32578366.560	3.493	1.804	0.005	0.014
Cytidine	1.451	985907272.287	35912255.949	1432654761.643	55566587.145	0.688	-0.539	0.005	0.014
Uridine	1.234	306764557.012	6498217.377	322928169.277	5050340.318	0.950	-0.074	0.005	0.014
Abscisic aldehyde	1.081	2718908.664	231351.959	15554720.629	9263949.194	0.175	-2.516	0.005	0.014
Ubiquinone-1	1.446	64763687.904	5212239.208	29299718.448	2499315.597	2.210	1.144	0.005	0.014
Deoxyadenosine	1.474	223558501.661	5856435.305	640690904.756	19089339.950	0.349	-1.519	0.005	0.014
Nicotinate D-ribonucleoside	1.472	302937409.256	6899094.436	520860443.550	11702182.367	0.582	-0.782	0.005	0.014
Glycerophosphocholine	1.459	89095977.604	5986200.355	190402596.462	10753164.549	0.468	-1.096	0.005	0.014
Alpha-Linolenic acid	1.468	90569461.614	3432692.744	30305417.897	3892493.766	2.989	1.579	0.005	0.014
Adenosine	1.476	2481316633.774	58137637.792	12754344150.537	293396346.839	0.195	-2.362	0.005	0.014
(2E,4Z,7Z,8E)-Colnelenic acid	1.095	300160726.329	137279565.278	104497583.072	2577598.759	2.872	1.522	0.005	0.014
9-OxoODE	1.401	180406552.720	11684954.247	244040851.183	11596611.883	0.739	-0.436	0.005	0.014
Stearidonic acid	1.335	645740215.230	197225380.330	97578895.917	39531846.702	6.618	2.726	0.005	0.014
Ophthalmate	1.336	3076694.475	2305798.430	9602239.452	625868.794	0.320	-1.642	0.005	0.014
Etherolenic acid	1.453	1764519320.740	58739269.252	997043178.280	93022905.873	1.770	0.824	0.005	0.014
13-L-Hydroperoxylinoleic acid	1.471	451638677.402	12201437.082	725996209.503	15231285.573	0.622	-0.685	0.005	0.014
12,13-DHOME	1.467	37947022.226	3504312.496	100141628.299	4658823.648	0.379	-1.400	0.005	0.014
15-Deoxy-d-12,14-PGJ2	1.444	94961472.526	5290990.308	42069132.761	7051388.780	2.257	1.175	0.005	0.014
Sphingosine	1.257	17036824.571	2013317.633	22646724.116	1777064.699	0.752	-0.411	0.005	0.014
Sphinganine	1.449	332549186.759	14712296.538	522719286.940	25376572.584	0.636	-0.652	0.005	0.014
Quercetin	1.287	308564755.490	6228857.435	343490288.646	13899703.695	0.898	-0.155	0.005	0.014
11(R)-HETE	1.343	17271375.275	2182165.940	5134945.767	3718749.877	3.364	1.750	0.005	0.014
13(S)-HpOTrE	1.473	283026553.946	7481262.734	141948403.051	4023215.178	1.994	0.996	0.005	0.014
9,10-12,13-Diepoxyoctadecanoate	1.441	35831367.087	4356739.992	68747089.358	3714825.870	0.521	-0.940	0.005	0.014
8,9-EET	1.473	51748248.702	1393148.679	21499153.198	1251924.615	2.407	1.267	0.005	0.014
3-CMP	1.399	51661041.619	3881570.926	70524834.732	3058572.781	0.733	-0.449	0.005	0.014
Prostaglandin E2	1.298	42093328.488	1541752.893	33814107.671	3129312.660	1.245	0.316	0.005	0.014
11,12,15-THETA	1.467	5069094.494	1551592.463	34920815.191	2247288.734	0.145	-2.784	0.005	0.014
Isocorypalmine	1.256	12645715.447	6995713.186	31355493.444	5635267.562	0.403	-1.310	0.005	0.014
dGMP	1.303	7690118.540	1542331.266	11469410.341	267908.514	0.670	-0.577	0.005	0.014
Prostaglandin G2	1.471	1076362703.764	35635633.886	566883369.593	10342742.640	1.899	0.925	0.005	0.014
Prostaglandin I2	1.343	331541433.620	8913801.977	144162719.638	66008861.014	2.300	1.202	0.005	0.014
Chlorogenic acid	1.369	57374109.783	6091510.034	36304362.626	2602337.222	1.580	0.660	0.005	0.014
Riboflavin	1.188	174920101.962	18138611.805	138365540.204	10430898.915	1.264	0.338	0.005	0.014
Desmosterol	1.379	3321004.612	2169439.924	12547478.949	1690203.619	0.265	-1.918	0.005	0.014
Calcitriol	1.317	26754239.439	1310774.119	11338990.406	5929216.292	2.360	1.238	0.005	0.014
Trehalose 6-phosphate	1.438	30401919.191	10589587.094	105961856.218	8887156.604	0.287	-1.801	0.005	0.014
Phenylacetic acid	1.194	15100166.992	3553021.541	26235499.887	5188540.588	0.576	-0.797	0.008	0.020
L-Arginine	1.158	607660616.153	32493906.705	501757784.821	56245759.147	1.211	0.276	0.008	0.020
N-Acetylmuramate	1.165	18898865.893	633298.350	17506438.572	553957.898	1.079	0.110	0.008	0.020
Cellobiose	1.263	33924529.139	2635191.901	42309460.362	2925890.387	0.802	-0.319	0.008	0.020
L-2,4-diaminobutyric acid	1.107	118011963.824	3797265.543	105878573.686	7381547.509	1.115	0.157	0.013	0.029
Pyroglutamic acid	1.045	69245389.084	25686939.169	25576884.109	21992381.797	2.707	1.437	0.013	0.029
Perillic acid	1.101	65968716.749	3587154.368	59841715.472	2271035.705	1.102	0.141	0.013	0.029
Uric acid	1.189	17688069.442	1075362.158	15468439.260	671434.976	1.143	0.193	0.013	0.029
Limonene-1,2-diol	1.129	21385415.267	1611929.720	24177914.661	852105.514	0.884	-0.177	0.013	0.029
(Z)-But-1-ene-1,2,4-tricarboxylate	1.193	147220232.493	39330603.236	497844940.823	194564485.085	0.296	-1.758	0.013	0.029
gamma-Glutamyl-beta-aminopropiononitrile	1.014	5078227.292	1645066.219	7259502.736	701306.117	0.700	-0.516	0.013	0.029
Isochavicol	1.154	83703476.214	13096780.043	53759272.177	13121809.338	1.557	0.639	0.020	0.042
Mannitol	1.058	91824336.680	34018214.655	178897808.301	56182200.219	0.513	-0.962	0.020	0.042
N-Acetyl-L-glutamate 5-semialdehyde	1.062	197404525.290	80953126.095	372553285.519	103182978.671	0.530	-0.916	0.031	0.059
8-Isoprostane	1.083	34489491.900	837090.676	32052698.656	1539266.684	1.076	0.106	0.031	0.059
2-Hydroxybutyric acid	1.030	41083468.007	1828244.792	36107347.172	3513372.429	1.138	0.186	0.045	0.081
beta-Alanyl-L-arginine	1.056	6829763.753	3817193.907	12219711.954	1441091.530	0.559	-0.839	0.045	0.081
5,6-DHET	1.100	40388837.428	4504791.198	26880410.768	8226488.629	1.502	0.587	0.045	0.081
Pyruvic acid	1.441	246401890.953	6012539.013	309835388.963	12470769.420	0.795	-0.330	0.005	0.014
Fumaric acid	1.417	42339782.095	2728988.374	58763777.104	3372870.460	0.721	-0.473	0.005	0.014
Succinic acid	1.271	1790586.503	1833450.860	14901147.223	6051011.284	0.120	-3.057	0.005	0.014
Adenine	1.475	2318561649.751	168416410.430	882631808.134	94794964.732	2.627	1.393	0.005	0.014
3-Hydroxybenzoic acid	1.133	2189769.946	979150.885	9872682.199	5048180.853	0.222	-2.173	0.005	0.014
L-Arabinose	1.478	29041211.858	733363.508	21089296.903	678649.265	1.377	0.462	0.005	0.014
3-Hydroxyanthranilic acid	1.441	8959046.281	668210.146	4460400.232	720031.047	2.009	1.006	0.005	0.014
Gentisic acid	1.312	60221118.411	12986504.617	18694458.875	12000862.242	3.221	1.688	0.005	0.014
Phenylpyruvic acid	1.317	35837140.562	1006294.748	29982180.180	2237331.241	1.195	0.257	0.005	0.014
Quinate	1.443	9926384909.776	545953479.896	18266433572.830	1698785987.273	0.543	-0.880	0.005	0.014
trans-Ferulic acid	1.492	58183935.893	1513218.733	23061691.972	1837459.881	2.523	1.335	0.005	0.014
Gluconic acid	1.363	41511061.348	9491909.217	13450391.540	2798595.025	3.086	1.626	0.005	0.014
L-Tryptophan	1.475	791368369.025	38477205.082	1151168025.881	28825514.369	0.687	-0.541	0.005	0.014
N-Acetyl-L-phenylalanine	1.492	98213809.816	4950589.104	18340859.652	1816273.473	5.355	2.421	0.005	0.014
Galactosylglycerol	1.469	91335576.819	11425203.024	11035259.880	4457444.736	8.277	3.049	0.005	0.014
Deoxyguanosine	1.476	7437930.108	1138200.669	16344583.776	281141.987	0.455	-1.136	0.005	0.014
2-O-(alpha-D-Mannosyl)-D-glycerate	1.463	22026964.194	1353959.437	13555982.143	452488.555	1.625	0.700	0.005	0.014
Inosine	1.419	846653.253	223180.821	2695760.776	428189.470	0.314	-1.671	0.005	0.014
Hexadecanedioate	1.340	18137494.074	6465673.648	35250547.319	1308201.873	0.515	-0.959	0.005	0.014
16-Hydroxy hexadecanoic acid	1.482	195995420.178	10379315.667	362730203.134	15759232.599	0.540	-0.888	0.005	0.014
13(S)-HOT	1.494	1897660951.679	77398443.115	473426330.265	7484650.228	4.008	2.003	0.005	0.014
Guanosine	1.464	17258453.502	994860.948	57737444.407	6625207.894	0.299	-1.742	0.005	0.014
Melibiitol	1.348	7909227.721	1778491.716	2557091.912	923488.893	3.093	1.629	0.005	0.014
p-Coumaroyl quinic acid	1.493	95332704.641	4704897.747	8359778.847	843237.024	11.404	3.511	0.005	0.014
trans-Zeatin riboside	1.440	3332945.950	360949.812	9054811.690	1205648.542	0.368	-1.442	0.005	0.014
Prostaglandin H2	1.411	59936214.686	2572559.746	100838709.104	10924040.784	0.594	-0.751	0.005	0.014
Xanthohumol	1.480	25211266.313	1849480.987	7050548.596	1074510.964	3.576	1.838	0.005	0.014
Geniposidic acid	1.476	24493995.795	1917293.157	9233972.997	628863.674	2.653	1.407	0.005	0.014
Quercetin 3-O-glucoside	1.251	35829736.574	14524502.682	558660793.938	266083486.797	0.064	-3.963	0.005	0.014
Malonate	1.319	35112239.838	3677492.489	18252321.441	5982696.418	1.924	0.944	0.008	0.021
Dihydrouracil	1.055	6297182.978	754108.499	16020059.397	7545710.858	0.393	-1.347	0.008	0.021
L-Arogenate	1.224	10187584.451	3224930.522	3667410.382	1502838.327	2.778	1.474	0.008	0.021
L-Cystine	1.132	169061831.054	90077991.052	375500299.007	105230305.651	0.450	-1.151	0.013	0.030
UMP	1.078	18785843.730	3179298.963	12918962.774	3009838.562	1.454	0.540	0.013	0.030
Kynurenic acid	1.137	15680730.537	789417.523	13866344.148	909369.216	1.131	0.177	0.020	0.044
Prunasin	1.059	10835223.356	898090.079	13196707.550	1590618.263	0.821	-0.284	0.031	0.061
Chitobiose	1.004	27523197.202	1843481.232	23914052.053	2484352.515	1.151	0.203	0.031	0.061
Cyclic GMP	1.024	21090706.127	946984.793	16499146.045	3672210.001	1.278	0.354	0.045	0.084

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值

	VIP	mean_B	sd_B	mean_C	sd_C	Fold Change_B/C	log2(FC_B/C)	p.value	FDR
2-Ketobutyric acid	1.325	139080543.811	10607936.288	112563446.849	6080935.778	1.236	0.305	0.005	0.016
2-Hydroxybutyric acid	1.499	56909222.303	1639886.707	36107347.172	3513372.429	1.576	0.656	0.005	0.016
gamma-Aminobutyric acid	1.486	6235996910.267	160973984.405	4717103949.548	283678902.459	1.322	0.403	0.005	0.016
2-Phenylethanol	1.482	36652175.826	1485776.610	48339088.423	2156420.712	0.758	-0.399	0.005	0.016
Cytosine	1.496	965884640.192	49540896.729	1299864608.381	42315901.201	0.743	-0.428	0.005	0.016
Maleamate	1.515	80585667.724	1882861.636	61176481.187	2149246.120	1.317	0.398	0.005	0.016
Indole	1.534	164087336.275	4565888.942	269043647.879	7232286.445	0.610	-0.713	0.005	0.016
L-Valine	1.512	3110350257.982	135328377.142	4256082523.818	117243419.153	0.731	-0.452	0.005	0.016
Betaine	1.308	861264517.776	327079637.741	172741608.371	64684976.441	4.986	2.318	0.005	0.016
4-Hydroxybenzoic acid	1.537	16466741.250	586667.130	3183104.032	612528.715	5.173	2.371	0.005	0.016
Tyrosol	1.471	420356676.652	83196780.077	78878028.222	7312406.582	5.329	2.414	0.005	0.016
Thymine	1.492	23378222.699	3234615.385	87713307.469	12599998.433	0.267	-1.908	0.005	0.016
Oxoglutaric acid	1.411	20284463.313	846274.454	16627164.058	922218.870	1.220	0.287	0.005	0.016
Pipecolic acid	1.476	1358672622.592	46529472.545	1130694691.193	26074471.897	1.202	0.265	0.005	0.016
Pyroglutamic acid	1.398	87098300.745	3240632.369	25576884.109	21992381.797	3.405	1.768	0.005	0.016
N-Acetylputrescine	1.300	258461370.318	15922650.185	302331812.179	14709350.213	0.855	-0.226	0.005	0.016
3-Methylindole	1.521	134344416.882	7121347.165	236253412.114	11065042.763	0.569	-0.814	0.005	0.016
L-Aspartic acid	1.517	779268723.028	30755622.484	536501006.845	15441516.496	1.452	0.539	0.005	0.016
2-Phenylacetamide	1.532	769092332.682	13136646.185	513483783.712	19045527.409	1.498	0.583	0.005	0.016
2-Aminobenzoic acid	1.516	6721706.799	766703.348	15240429.951	951973.664	0.441	-1.181	0.005	0.016
Hypoxanthine	1.459	89129315.715	4354772.879	68759339.557	3229916.876	1.296	0.374	0.005	0.016
Phenylacetic acid	1.220	16606134.996	2514020.921	26235499.887	5188540.588	0.633	-0.660	0.005	0.016
Tyramine	1.459	126538393.911	27405406.924	23442548.911	1227764.758	5.398	2.432	0.005	0.016
6-Hydroxynicotinic acid	1.494	41161109.436	1531585.741	30145103.296	1552858.270	1.365	0.449	0.005	0.016
Ectoine	1.437	34168249.270	1890080.672	24282298.902	2305842.922	1.407	0.493	0.005	0.016
2-Dehydropantoate	1.517	339420960.657	25108266.387	585631009.211	23939545.031	0.580	-0.787	0.005	0.016
Coumarin	1.534	139845264.651	3472264.063	91673409.280	1918256.985	1.526	0.609	0.005	0.016
L-Glutamine	1.437	1514509841.263	60375001.578	1226092202.748	62977857.075	1.235	0.305	0.005	0.016
L-Lysine	1.495	656247753.433	24970686.729	490083020.475	21199356.564	1.339	0.421	0.005	0.016
L-Methionine	1.511	1175494089.376	34340930.506	881401049.166	31699406.122	1.334	0.415	0.005	0.016
Xanthine	1.519	11941152.944	1047377.415	3585277.400	442321.617	3.331	1.736	0.005	0.016
D-Arabitol	1.457	18922842.738	7091095.343	48806879.341	3745289.643	0.388	-1.367	0.005	0.016
Pulegone	1.539	63509264.755	2441610.742	141173015.185	2988159.818	0.450	-1.152	0.005	0.016
Aminoadipic acid	1.519	51752408.091	3134356.503	107787356.903	6965782.760	0.480	-1.058	0.005	0.016
2-Hydroxy-2-ethylsuccinic acid	1.510	24265242.631	935768.533	31270680.577	635716.004	0.776	-0.366	0.005	0.016
Nicotine	1.334	40585256.059	1166413.061	36031224.751	1681495.920	1.126	0.172	0.005	0.016
Normetanephrine	1.432	17533390.177	12202408.977	58856613.881	3767609.445	0.298	-1.747	0.005	0.016
L-4-Hydroxyphenylglycine	1.448	490563394.014	24342389.645	390482628.868	14547400.668	1.256	0.329	0.005	0.016
Perillic acid	1.410	68528351.928	1925863.572	59841715.472	2271035.705	1.145	0.196	0.005	0.016
3-Methoxyanthranilate	1.338	142196552.702	4379420.160	160048205.262	6606550.183	0.888	-0.171	0.005	0.016
Uric acid	1.441	20750081.776	1411980.640	15468439.260	671434.976	1.341	0.424	0.005	0.016
(1S,4R)-1-Hydroxy-2-oxolimonene	1.312	12768160.329	1605665.373	4854411.607	3431670.837	2.630	1.395	0.005	0.016
Pyridoxine	1.512	69961246.561	2917306.887	95439919.112	2680743.719	0.733	-0.448	0.005	0.016
Limonene-1,2-diol	1.368	28969911.905	1735534.289	24177914.661	852105.514	1.198	0.261	0.005	0.016
N-Acetyl-L-glutamate 5-semialdehyde	1.266	174706822.996	27021151.250	372553285.519	103182978.671	0.469	-1.093	0.005	0.016
N-Acetylornithine	1.459	72819417.217	5017351.881	52469714.728	2031768.973	1.388	0.473	0.005	0.016
Serotonin	1.380	12227540.672	789408.889	15578757.974	1025017.040	0.785	-0.349	0.005	0.016
Kanosamine	1.452	27422702.738	2028533.285	37790780.787	2030627.970	0.726	-0.463	0.005	0.016
2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid	1.538	12493463.220	2144440.852	78214014.321	3195074.225	0.160	-2.646	0.005	0.016
myo-Inositol	1.319	83280629.865	7847358.517	103742168.177	5544635.215	0.803	-0.317	0.005	0.016
L-Tyrosine	1.538	2795093525.823	38739365.541	1841414674.705	37824118.803	1.518	0.602	0.005	0.016
Mannitol	1.389	26620536.533	8910195.694	178897808.301	56182200.219	0.149	-2.748	0.005	0.016
Diaminopimelic acid	1.459	62966694.369	2590519.043	74883979.765	1806525.989	0.841	-0.250	0.005	0.016
2-Amino-2-deoxy-D-gluconate	1.451	10941732.273	1077838.689	18375493.012	1765851.791	0.595	-0.748	0.005	0.016
L-Dopa	1.124	13084489.267	371436.659	14607725.456	1043702.145	0.896	-0.159	0.005	0.016
gamma-Glutamyl-beta-aminopropiononitrile	1.299	13994735.991	3268842.551	7259502.736	701306.117	1.928	0.947	0.005	0.016
Spermine	1.500	42265241.833	2244959.191	28704081.689	1117830.474	1.472	0.558	0.005	0.016
3-[(1-Carboxyvinyl)oxy]benzoate	1.221	32664424.715	16515627.908	4937028.271	1175549.057	6.616	2.726	0.005	0.016
Dethiobiotin	1.408	43758565.220	2832039.864	60397161.082	5006477.864	0.725	-0.465	0.005	0.016
beta-Alanyl-L-lysine	1.482	39332578.296	1566363.547	23473973.706	3185842.537	1.676	0.745	0.005	0.016
Pyrimidodiazepine	1.520	54029172.311	2229397.317	85688152.213	3584202.762	0.631	-0.665	0.005	0.016
2-trans,6-trans-Farnesal	1.372	17318943.307	1290433.159	22797198.075	1755367.851	0.760	-0.397	0.005	0.016
N-Acetyl-D-glucosamine	1.489	112362609.872	4229325.420	205015415.740	18968437.328	0.548	-0.868	0.005	0.016
Porphobilinogen	1.499	141644947.278	5028559.586	106635597.270	4203734.813	1.328	0.410	0.005	0.016
Traumatic Acid	1.526	130366083.868	7077772.546	63652249.378	2358258.958	2.048	1.034	0.005	0.016
L-Formylkynurenine	1.347	140262054.721	8484477.409	62346627.989	32578366.560	2.250	1.170	0.005	0.016
Cytidine	1.470	1100150784.412	60284092.740	1432654761.643	55566587.145	0.768	-0.381	0.005	0.016
Uridine	1.405	304114461.789	4229289.861	322928169.277	5050340.318	0.942	-0.087	0.005	0.016
Ubiquinone-1	1.521	60404513.966	3218117.255	29299718.448	2499315.597	2.062	1.044	0.005	0.016
Deoxyadenosine	1.540	197133742.699	2214727.229	640690904.756	19089339.950	0.308	-1.700	0.005	0.016
Nicotinate D-ribonucleoside	1.509	747351455.024	35190887.740	520860443.550	11702182.367	1.435	0.521	0.005	0.016
Glycerophosphocholine	1.476	133203085.145	7956261.590	190402596.462	10753164.549	0.700	-0.515	0.005	0.016
Alpha-Linolenic acid	1.508	71249865.916	5616133.755	30305417.897	3892493.766	2.351	1.233	0.005	0.016
Adenosine	1.397	13993797296.116	338749593.627	12754344150.537	293396346.839	1.097	0.134	0.005	0.016
9-OxoODE	1.432	291135960.251	8909430.147	244040851.183	11596611.883	1.193	0.255	0.005	0.016
EPA (d5)	1.206	15778606.013	3504829.932	166151595.495	92769500.019	0.095	-3.397	0.005	0.016
Etherolenic acid	1.506	1607382023.843	46104704.378	997043178.280	93022905.873	1.612	0.689	0.005	0.016
N-Acetylmuramate	1.302	10092060.744	3606191.803	17506438.572	553957.898	0.576	-0.795	0.005	0.016
13-L-Hydroperoxylinoleic acid	1.494	841157367.393	17008857.311	725996209.503	15231285.573	1.159	0.212	0.005	0.016
Sphinganine	1.170	442497741.130	46982097.536	522719286.940	25376572.584	0.847	-0.240	0.005	0.016
Quercetin	1.444	408319201.305	12669298.911	343490288.646	13899703.695	1.189	0.249	0.005	0.016
19(R)-HETE	1.304	23974719.730	1926582.342	31394832.075	3076882.859	0.764	-0.389	0.005	0.016
16(R)-HETE	1.222	10839787.163	1153665.368	47659306.653	21925285.605	0.227	-2.136	0.005	0.016
2,3-Dinor-8-iso prostaglandin F2alpha	1.370	139769034.207	7172311.810	76902422.608	24112868.779	1.817	0.862	0.005	0.016
13(S)-HpOTrE	1.538	248625351.951	4424229.666	141948403.051	4023215.178	1.752	0.809	0.005	0.016
5(S)-HpETE	1.406	17922893.941	6201013.484	36387971.096	1759716.057	0.493	-1.022	0.005	0.016
8,9-EET	1.531	42870452.843	1560530.961	21499153.198	1251924.615	1.994	0.996	0.005	0.016
11,12-EET	1.382	20906091.733	3640807.176	8026514.750	3341421.431	2.605	1.381	0.005	0.016
5,6-DHET	1.348	5960641.399	3638191.617	26880410.768	8226488.629	0.222	-2.173	0.005	0.016
Senecionine	1.520	35884300.294	585518.071	23660664.877	1529055.620	1.517	0.601	0.005	0.016
8-Isoprostane	1.452	19808321.126	3019359.990	32052698.656	1539266.684	0.618	-0.694	0.005	0.016
11,12,15-THETA	1.234	18308335.977	9388526.378	34920815.191	2247288.734	0.524	-0.932	0.005	0.016
Isocorypalmine	1.258	15836228.408	6391153.082	31355493.444	5635267.562	0.505	-0.985	0.005	0.016
Cellobiose	1.370	31021992.739	3452498.894	42309460.362	2925890.387	0.733	-0.448	0.005	0.016
Prostaglandin G2	1.540	1280763620.696	29870147.574	566883369.593	10342742.640	2.259	1.176	0.005	0.016
Chlorogenic acid	1.326	25434213.699	4265181.619	36304362.626	2602337.222	0.701	-0.513	0.005	0.016
GMP	1.432	86049585.444	19725137.858	14855320.757	9875315.932	5.793	2.534	0.005	0.016
Riboflavin	1.442	335758583.910	56909291.323	138365540.204	10430898.915	2.427	1.279	0.005	0.016
Desmosterol	1.435	6650889.751	605283.907	12547478.949	1690203.619	0.530	-0.916	0.005	0.016
Trehalose 6-phosphate	1.385	45057586.086	21311863.724	105961856.218	8887156.604	0.425	-1.234	0.005	0.016
Amygdalin	1.385	1998373.510	1193556.541	11252359.542	3300344.664	0.178	-2.493	0.005	0.016
Rutin	1.516	2084981939.839	58935909.745	1376758258.689	84566843.072	1.514	0.599	0.005	0.016
Maleic acid	1.008	4913433.204	3576085.790	35286775.563	26989900.541	0.139	-2.844	0.008	0.022
L-Isoleucine	1.293	149544001.246	151889378.004	1368002882.388	594388587.162	0.109	-3.193	0.008	0.022
Perillyl alcohol	1.344	74754872.672	5291139.278	92781629.830	5822477.760	0.806	-0.312	0.008	0.022
Anabasine	1.292	35013100.155	1995521.198	40236443.664	1723062.385	0.870	-0.201	0.008	0.022
Ascorbate	1.226	12191034.644	7404987.747	47571651.561	19538386.820	0.256	-1.964	0.008	0.022
Pantothenic acid	1.210	107923624.883	4891306.316	118856177.445	4559774.206	0.908	-0.139	0.008	0.022
Stearidonic acid	1.050	318877616.759	180195823.177	97578895.917	39531846.702	3.268	1.708	0.008	0.022
15-Deoxy-d-12,14-PGJ2	1.231	29393681.872	2276273.523	42069132.761	7051388.780	0.699	-0.517	0.008	0.022
9,10-12,13-Diepoxyoctadecanoate	1.272	57673797.760	4562883.452	68747089.358	3714825.870	0.839	-0.253	0.008	0.022
Prostaglandin D2	1.186	3825849.719	3017743.755	11592274.407	3989245.251	0.330	-1.599	0.008	0.022
D-Phenyllactic acid	1.157	26622657.122	8431804.383	40632444.094	4496943.914	0.655	-0.610	0.013	0.032
(+)-7-Isojasmonic acid	1.153	65742367.872	5064428.828	82020600.706	10002104.437	0.802	-0.319	0.013	0.032
Ophthalmate	1.163	11098290.154	792642.405	9602239.452	625868.794	1.156	0.209	0.013	0.032
Sphingosine	1.161	25982400.543	1397919.597	22646724.116	1777064.699	1.147	0.198	0.013	0.032
11(R)-HETE	1.148	14010393.385	4921310.790	5134945.767	3718749.877	2.728	1.448	0.013	0.032
4-Hydroxybutanoic acid	1.034	34762393.535	2659172.824	40326947.011	3957965.249	0.862	-0.214	0.020	0.045
Oleic acid	1.019	101933855.761	9910051.469	118051908.301	10136098.881	0.863	-0.212	0.020	0.045
Hydrogen phosphate	1.039	149064853.442	51157056.661	56688061.515	59467097.483	2.630	1.395	0.031	0.062
Chavicol	1.096	34438341.633	4952674.996	21053039.979	8995571.553	1.636	0.710	0.031	0.062
trans-Cinnamate	1.031	144168031.110	6198909.986	133828117.878	6393636.389	1.077	0.107	0.031	0.062
Sorbitol	1.019	21651142.756	15397744.839	105455234.422	72110793.923	0.205	-2.284	0.031	0.062
L-Kynurenine	1.173	6262127.868	2998840.519	22054780.439	10003112.249	0.284	-1.816	0.031	0.062
12,13-DHOME	1.002	91611322.698	6174124.035	100141628.299	4658823.648	0.915	-0.128	0.031	0.062
9(S)-HPETE	1.100	6489415.770	2891453.257	20358344.360	10156235.997	0.319	-1.649	0.031	0.062
Acetoacetic acid	1.050	424023766.068	11311911.879	402907943.003	13479807.471	1.052	0.074	0.045	0.085
4-Hydroxyphenylacetaldehyde	1.075	31790927.567	18995726.813	7757606.324	2394433.737	4.098	2.035	0.045	0.085
p-Aminobenzoic acid	1.047	142568007.754	82457638.123	38986576.455	26829665.350	3.657	1.871	0.045	0.085
L-Alanine	1.127	26050115.531	12726680.533	113544452.979	67275039.456	0.229	-2.124	0.005	0.017
Phenylethylamine	1.450	42104612.406	1715018.680	54988342.526	4361867.344	0.766	-0.385	0.005	0.017
L-Glutamic acid	1.441	135817825.017	8733257.999	100962262.907	9768365.169	1.345	0.428	0.005	0.017
Phenylpyruvic acid	1.428	23626452.975	1110355.385	29982180.180	2237331.241	0.788	-0.344	0.005	0.017
Kynurenic acid	1.548	9240737.442	275186.378	13866344.148	909369.216	0.666	-0.586	0.005	0.017
Quinate	1.382	14051053509.383	875090810.363	18266433572.830	1698785987.273	0.769	-0.379	0.005	0.017
trans-Ferulic acid	1.392	27353767.196	451365.283	23061691.972	1837459.881	1.186	0.246	0.005	0.017
Gluconic acid	1.565	34897143.641	2276290.666	13450391.540	2798595.025	2.595	1.375	0.005	0.017
Vanillylmandelic acid	1.298	17972790.641	852913.680	21654053.847	1875713.951	0.830	-0.269	0.005	0.017
L-Tryptophan	1.591	586750518.044	40063931.061	1151168025.881	28825514.369	0.510	-0.972	0.005	0.017
Deoxyguanosine	1.587	5631502.298	1089389.672	16344583.776	281141.987	0.345	-1.537	0.005	0.017
Inosine	1.522	18610747.356	4006199.586	2695760.776	428189.470	6.904	2.787	0.005	0.017
Hexadecanedioate	1.414	15181052.763	8153450.054	35250547.319	1308201.873	0.431	-1.215	0.005	0.017
16-Hydroxy hexadecanoic acid	1.583	203823301.287	9870704.357	362730203.134	15759232.599	0.562	-0.832	0.005	0.017
13(S)-HOT	1.594	981183682.733	37202024.504	473426330.265	7484650.228	2.072	1.051	0.005	0.017
Guanosine	1.592	150333166.469	4293196.974	57737444.407	6625207.894	2.604	1.381	0.005	0.017
Prunasin	1.462	8196458.266	687181.548	13196707.550	1590618.263	0.621	-0.687	0.005	0.017
Dhurrin	1.131	13677621.793	3526676.738	28573569.646	11018247.070	0.479	-1.063	0.005	0.017
p-Coumaroyl quinic acid	1.598	55716074.951	2059982.527	8359778.847	843237.024	6.665	2.737	0.005	0.017
Cyclic GMP	1.551	43325832.279	3908203.212	16499146.045	3672210.001	2.626	1.393	0.005	0.017
trans-Zeatin riboside	1.537	3532574.791	321976.543	9054811.690	1205648.542	0.390	-1.358	0.005	0.017
Prostaglandin H2	1.543	47115010.449	3712252.467	100838709.104	10924040.784	0.467	-1.098	0.005	0.017
Geniposidic acid	1.514	14812400.952	1351303.097	9233972.997	628863.674	1.604	0.682	0.005	0.017
Quercetin 3-O-glucoside	1.340	33713701.701	8234944.375	558660793.938	266083486.797	0.060	-4.051	0.005	0.017
Protocatechuic acid	1.094	28641293.426	8211864.463	44265659.991	9991992.474	0.647	-0.628	0.020	0.050
2-Dehydro-3-deoxy-L-arabinonate	1.070	4474388.749	3386874.012	19687012.529	12680922.163	0.227	-2.138	0.031	0.068
N-Acetyl-L-phenylalanine	1.172	24495564.728	4049400.021	18340859.652	1816273.473	1.336	0.417	0.031	0.068
Urocanic acid	1.233	13370844.393	5040920.433	5143084.236	1571025.279	2.600	1.378	0.045	0.091
L-Phenylalanine	1.135	81061327.212	1479771.066	78024036.561	1814256.812	1.039	0.055	0.045	0.091
Ribose 1,5-bisphosphate	1.068	45401318.057	9454846.443	73002593.530	21955995.715	0.622	-0.685	0.045	0.091

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值

	VIP	p.value	FDR
2-Ketobutyric acid	1.714	0.001	0.005
2-Phenylethanol	1.693	0.001	0.005
Cytosine	1.690	0.001	0.005
4-Hydroxybenzoic acid	1.793	0.001	0.005
Thymine	1.311	0.001	0.005
Oxoglutaric acid	1.689	0.001	0.005
Pipecolic acid	1.746	0.001	0.005
N-Acetylputrescine	1.373	0.001	0.005
3-Methylindole	1.094	0.001	0.005
Hypoxanthine	1.680	0.001	0.005
6-Hydroxynicotinic acid	1.715	0.001	0.005
Ectoine	1.600	0.001	0.005
L-Glutamine	1.728	0.001	0.005
Pulegone	1.364	0.001	0.005
2-Hydroxy-2-ethylsuccinic acid	1.267	0.001	0.005
Nicotine	1.672	0.001	0.005
L-4-Hydroxyphenylglycine	1.758	0.001	0.005
3-Methoxyanthranilate	1.713	0.001	0.005
(1S,4R)-1-Hydroxy-2-oxolimonene	1.718	0.001	0.005
Pyridoxine	1.785	0.001	0.005
Serotonin	1.731	0.001	0.005
Kanosamine	1.006	0.001	0.005
myo-Inositol	1.731	0.001	0.005
L-Tyrosine	1.677	0.001	0.005
L-Dopa	1.281	0.001	0.005
Spermine	1.088	0.001	0.005
L-Formylkynurenine	1.728	0.001	0.005
Deoxyadenosine	1.506	0.001	0.005
Glycerophosphocholine	1.764	0.001	0.005
Alpha-Linolenic acid	1.740	0.001	0.005
Adenosine	1.461	0.001	0.005
9-OxoODE	1.007	0.001	0.005
Etherolenic acid	1.673	0.001	0.005
13-L-Hydroperoxylinoleic acid	1.229	0.001	0.005
Sphinganine	1.678	0.001	0.005
13(S)-HpOTrE	1.719	0.001	0.005
8,9-EET	1.741	0.001	0.005
Prostaglandin G2	1.242	0.001	0.005
Chlorogenic acid	1.114	0.001	0.005
Desmosterol	1.656	0.001	0.005
2-Phenylacetamide	1.647	0.001	0.005
Coumarin	1.678	0.001	0.005
Pantothenic acid	1.490	0.001	0.005
15-Deoxy-d-12,14-PGJ2	1.349	0.001	0.005
9,10-12,13-Diepoxyoctadecanoate	1.702	0.001	0.005
L-Lysine	1.696	0.001	0.005
Aminoadipic acid	1.396	0.001	0.005
Diaminopimelic acid	1.678	0.001	0.005
(+)-7-Isojasmonic acid	1.361	0.001	0.005
Cytidine	1.681	0.001	0.005
Ophthalmate	1.286	0.001	0.005
Sphingosine	1.025	0.001	0.005
11,12,15-THETA	1.654	0.001	0.005
Isochavicol	1.062	0.001	0.006
L-Threonine	1.307	0.001	0.006
3-[(1-Carboxyvinyl)oxy]benzoate	1.564	0.001	0.006
12,13-DHOME	1.638	0.001	0.006
Maleamate	1.659	0.001	0.006
(2E,4Z,7Z,8E)-Colnelenic acid	1.227	0.001	0.006
Stearidonic acid	1.512	0.001	0.006
Pyroglutamic acid	1.020	0.001	0.006
Pyrimidodiazepine	1.445	0.001	0.006
Abscisic aldehyde	1.209	0.002	0.007
Ubiquinone-1	1.611	0.002	0.007
3-CMP	1.558	0.002	0.007
Chavicol	1.219	0.002	0.007
Calcitriol	1.199	0.002	0.007
gamma-Aminobutyric acid	1.445	0.003	0.008
Trehalose 6-phosphate	1.570	0.003	0.008
Cellobiose	1.115	0.003	0.008
L-Asparagine	1.541	0.003	0.008
2-Amino-2-deoxy-D-gluconate	1.411	0.003	0.008
Prostaglandin I2	1.397	0.003	0.008
Isocorypalmine	1.371	0.003	0.008
dGMP	1.323	0.003	0.008
trans-Cinnamate	1.438	0.003	0.008
2-trans,6-trans-Farnesal	1.458	0.003	0.008
L-Aspartic acid	1.564	0.003	0.008
N-Acetyl-D-glucosamine	1.439	0.003	0.008
Uridine	1.232	0.003	0.008
Alpha-D-Glucose	1.148	0.003	0.008
L-Methionine S-oxide	1.549	0.003	0.008
Phosphorylcholine	1.388	0.003	0.008
Phenylacetic acid	1.343	0.003	0.008
Acetylphosphate	1.302	0.003	0.008
4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine	1.193	0.003	0.008
Anabasine	1.148	0.004	0.009
Perillic acid	1.024	0.004	0.009
11(R)-HETE	1.443	0.004	0.009
Guanine	1.065	0.006	0.011
L-2,4-diaminobutyric acid	1.165	0.006	0.012
(Z)-But-1-ene-1,2,4-tricarboxylate	1.197	0.006	0.012
4-Hydroxyphenylacetaldehyde	1.302	0.007	0.013
L-Arginine	1.052	0.008	0.015
Formylanthranilic acid	1.087	0.010	0.017
4-Hydroxycinnamic acid	1.332	0.011	0.019
N-Acetyl-L-glutamate 5-semialdehyde	1.137	0.011	0.019
(S)-Norlaudanine	1.142	0.029	0.043
4-Hydroxybutanoic acid	1.140	0.029	0.043
Quercetin 3-(2G-xylosylrutinoside)	1.096	0.032	0.046
Pyrrole-2-carboxylic acid	1.049	0.047	0.065
Quinate	1.735	0.001	0.005
trans-Ferulic acid	1.658	0.001	0.005
L-Tryptophan	1.131	0.001	0.005
13(S)-HOT	1.785	0.001	0.005
p-Coumaroyl quinic acid	1.807	0.001	0.005
Prostaglandin H2	1.276	0.001	0.005
Geniposidic acid	1.758	0.001	0.005
N-Acetyl-L-phenylalanine	1.623	0.001	0.006
Deoxyguanosine	1.387	0.001	0.006
Xanthohumol	1.506	0.001	0.006
Gentisic acid	1.247	0.001	0.007
Gluconic acid	1.585	0.001	0.007
Pyruvic acid	1.011	0.002	0.007
Adenine	1.509	0.002	0.007
Galactosylglycerol	1.599	0.002	0.008
Fumaric acid	1.408	0.002	0.008
Hexadecanedioate	1.215	0.003	0.008
16-Hydroxy hexadecanoic acid	1.591	0.003	0.008
trans-Zeatin riboside	1.548	0.003	0.008
3-Hydroxyanthranilic acid	1.517	0.003	0.008
2-O-(alpha-D-Mannosyl)-D-glycerate	1.524	0.003	0.008
Melibiitol	1.419	0.003	0.008
Quercetin 3-O-glucoside	1.363	0.003	0.008
Malonate	1.339	0.004	0.009
Dihydrouracil	1.092	0.005	0.010
Succinic acid	1.312	0.005	0.010
L-Cystine	1.048	0.005	0.010
3-Hydroxybenzoic acid	1.268	0.008	0.015
L-Arogenate	1.158	0.016	0.028
Chitobiose	1.086	0.025	0.039

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值

	VIP	mean_A	sd_A	mean_B	sd_B	Fold Change_A/B	log2(FC_A/B)	p.value	FDR
Acetoacetic acid	1.432	371667297.266	4897743.120	424023766.068	11311911.879	0.877	-0.190	0.005	0.014
Hydrogen phosphate	1.150	57027598.221	30241663.649	149064853.442	51157056.661	0.383	-1.386	0.005	0.014
2-Ketobutyric acid	1.407	190479764.127	9845064.983	139080543.811	10607936.288	1.370	0.454	0.005	0.014
2-Hydroxybutyric acid	1.468	41083468.007	1828244.792	56909222.303	1639886.707	0.722	-0.470	0.005	0.014
2-Phenylethanol	1.332	17492799.788	7466387.994	36652175.826	1485776.610	0.477	-1.067	0.005	0.014
Cytosine	1.213	857359487.287	35131051.471	965884640.192	49540896.729	0.888	-0.172	0.005	0.014
L-2,4-diaminobutyric acid	1.388	118011963.824	3797265.543	104117564.043	2090518.839	1.133	0.181	0.005	0.014
Indole	1.384	214214492.004	15309622.725	164087336.275	4565888.942	1.306	0.385	0.005	0.014
L-Valine	1.155	4965394093.577	1175808362.304	3110350257.982	135328377.142	1.596	0.675	0.005	0.014
Betaine	1.162	274112970.214	171830163.158	861264517.776	327079637.741	0.318	-1.652	0.005	0.014
L-Threonine	1.458	296292136.643	10274379.320	426011466.232	20942492.887	0.696	-0.524	0.005	0.014
4-Hydroxybenzoic acid	1.483	31381263.687	1438147.327	16466741.250	586667.130	1.906	0.930	0.005	0.014
Tyrosol	1.235	261552009.476	13260891.568	420356676.652	83196780.077	0.622	-0.685	0.005	0.014
Thymine	1.215	36273344.549	6424790.158	23378222.699	3234615.385	1.552	0.634	0.005	0.014
Oxoglutaric acid	1.467	33220061.494	1857854.925	20284463.313	846274.454	1.638	0.712	0.005	0.014
Pipecolic acid	1.471	1841602801.178	53556257.479	1358672622.592	46529472.545	1.355	0.439	0.005	0.014
N-Acetylputrescine	1.478	510820622.366	26490211.699	258461370.318	15922650.185	1.976	0.983	0.005	0.014
3-Methylindole	1.355	172111772.217	11717656.893	134344416.882	7121347.165	1.281	0.357	0.005	0.014
L-Asparagine	1.429	292727493.851	12531177.304	205417893.924	16961309.296	1.425	0.511	0.005	0.014
Isochavicol	1.394	83703476.214	13096780.043	40040316.006	2003287.939	2.091	1.064	0.005	0.014
2-Aminobenzoic acid	1.110	16849473.595	7061101.038	6721706.799	766703.348	2.507	1.326	0.005	0.014
Hypoxanthine	1.486	181712662.544	7279573.556	89129315.715	4354772.879	2.039	1.028	0.005	0.014
Tyramine	1.177	80909162.990	4568444.484	126538393.911	27405406.924	0.639	-0.645	0.005	0.014
6-Hydroxynicotinic acid	1.488	76639414.798	2633005.384	41161109.436	1531585.741	1.862	0.897	0.005	0.014
Ectoine	1.487	178433924.823	12688313.703	34168249.270	1890080.672	5.222	2.385	0.005	0.014
2-Dehydropantoate	1.358	449776389.362	30604809.916	339420960.657	25108266.387	1.325	0.406	0.005	0.014
L-Glutamine	1.443	2119735836.599	113628205.775	1514509841.263	60375001.578	1.400	0.485	0.005	0.014
L-Methionine	1.455	862391638.776	47354396.933	1175494089.376	34340930.506	0.734	-0.447	0.005	0.014
Xanthine	1.473	2625414.112	769133.533	11941152.944	1047377.415	0.220	-2.185	0.005	0.014
D-Arabitol	1.261	35221771.743	3876362.961	18922842.738	7091095.343	1.861	0.896	0.005	0.014
Perillyl alcohol	1.312	87998849.362	1918546.256	74754872.672	5291139.278	1.177	0.235	0.005	0.014
Pulegone	1.448	78628685.658	1865345.068	63509264.755	2441610.742	1.238	0.308	0.005	0.014
2-Hydroxy-2-ethylsuccinic acid	1.472	51519725.978	3733339.357	24265242.631	935768.533	2.123	1.086	0.005	0.014
Alpha-D-Glucose	1.222	1291457059.125	98116498.905	1034470052.627	100736367.681	1.248	0.320	0.005	0.014
Nicotine	1.381	51151178.588	3217865.540	40585256.059	1166413.061	1.260	0.334	0.005	0.014
L-Methionine S-oxide	1.483	465475943.410	16306041.069	260761005.768	13843967.510	1.785	0.836	0.005	0.014
Normetanephrine	1.278	109520962.580	41622690.690	17533390.177	12202408.977	6.246	2.643	0.005	0.014
L-4-Hydroxyphenylglycine	1.451	651299906.848	20146128.351	490563394.014	24342389.645	1.328	0.409	0.005	0.014
3-Methoxyanthranilate	1.438	105215185.620	7051606.738	142196552.702	4379420.160	0.740	-0.435	0.005	0.014
Uric acid	1.198	17688069.442	1075362.158	20750081.776	1411980.640	0.852	-0.230	0.005	0.014
(1S,4R)-1-Hydroxy-2-oxolimonene	1.431	24532332.501	2277971.359	12768160.329	1605665.373	1.921	0.942	0.005	0.014
Pyridoxine	1.465	46488227.549	2458846.142	69961246.561	2917306.887	0.664	-0.590	0.005	0.014
Limonene-1,2-diol	1.388	21385415.267	1611929.720	28969911.905	1735534.289	0.738	-0.438	0.005	0.014
N-Acetylornithine	1.384	53950984.302	3342339.069	72819417.217	5017351.881	0.741	-0.433	0.005	0.014
Serotonin	1.477	4462011.106	603166.853	12227540.672	789408.889	0.365	-1.454	0.005	0.014
Kanosamine	1.461	51969994.567	3689924.862	27422702.738	2028533.285	1.895	0.922	0.005	0.014
D-Fructose	1.229	336185840.549	91445581.282	129829384.015	63136992.358	2.589	1.373	0.005	0.014
2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid	1.482	61986385.205	4940034.241	12493463.220	2144440.852	4.962	2.311	0.005	0.014
myo-Inositol	1.392	55784888.493	3057971.526	83280629.865	7847358.517	0.670	-0.578	0.005	0.014
L-Tyrosine	1.288	3000721799.312	86106556.148	2795093525.823	38739365.541	1.074	0.102	0.005	0.014
Mannitol	1.228	91824336.680	34018214.655	26620536.533	8910195.694	3.449	1.786	0.005	0.014
Phosphorylcholine	1.350	401348974.038	29196972.930	530919341.940	38239435.679	0.756	-0.404	0.005	0.014
(Z)-But-1-ene-1,2,4-tricarboxylate	1.304	147220232.493	39330603.236	514487556.317	155354154.147	0.286	-1.805	0.005	0.014
L-Dopa	1.472	19743322.575	881663.846	13084489.267	371436.659	1.509	0.594	0.005	0.014
gamma-Glutamyl-beta-aminopropiononitrile	1.323	5078227.292	1645066.219	13994735.991	3268842.551	0.363	-1.462	0.005	0.014
Spermine	1.491	7257139.129	819059.903	42265241.833	2244959.191	0.172	-2.542	0.005	0.014
(+)-7-Isojasmonic acid	1.478	157774684.634	10136912.563	65742367.872	5064428.828	2.400	1.263	0.005	0.014
Dethiobiotin	1.476	80112749.234	3765239.659	43758565.220	2832039.864	1.831	0.872	0.005	0.014
beta-Alanyl-L-lysine	1.465	25070708.537	1702694.481	39332578.296	1566363.547	0.637	-0.650	0.005	0.014
4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine	1.223	34902446.045	14702669.739	99678840.583	32206684.328	0.350	-1.514	0.005	0.014
Pantothenic acid	1.491	257003147.531	8875680.725	107923624.883	4891306.316	2.381	1.252	0.005	0.014
Porphobilinogen	1.473	101291118.512	2627823.898	141644947.278	5028559.586	0.715	-0.484	0.005	0.014
Traumatic Acid	1.477	71136597.569	2800988.249	130366083.868	7077772.546	0.546	-0.874	0.005	0.014
L-Formylkynurenine	1.466	217766716.814	8958112.246	140262054.721	8484477.409	1.553	0.635	0.005	0.014
Abscisic aldehyde	1.491	2718908.664	231351.959	15598225.883	849486.142	0.174	-2.520	0.005	0.014
Deoxyadenosine	1.431	223558501.661	5856435.305	197133742.699	2214727.229	1.134	0.181	0.005	0.014
Nicotinate D-ribonucleoside	1.489	302937409.256	6899094.436	747351455.024	35190887.740	0.405	-1.303	0.005	0.014
Glycerophosphocholine	1.437	89095977.604	5986200.355	133203085.145	7956261.590	0.669	-0.580	0.005	0.014
Alpha-Linolenic acid	1.370	90569461.614	3432692.744	71249865.916	5616133.755	1.271	0.346	0.005	0.014
Adenosine	1.496	2481316633.774	58137637.792	13993797296.116	338749593.627	0.177	-2.496	0.005	0.014
9-OxoODE	1.475	180406552.720	11684954.247	291135960.251	8909430.147	0.620	-0.690	0.005	0.014
Arachidonate	1.248	533729597.902	178962413.796	153355352.174	77970819.689	3.480	1.799	0.005	0.014
Ophthalmate	1.393	3076694.475	2305798.430	11098290.154	792642.405	0.277	-1.851	0.005	0.014
Etherolenic acid	1.276	1764519320.740	58739269.252	1607382023.843	46104704.378	1.098	0.135	0.005	0.014
N-Acetylmuramate	1.319	18898865.893	633298.350	10092060.744	3606191.803	1.873	0.905	0.005	0.014
13-L-Hydroperoxylinoleic acid	1.493	451638677.402	12201437.082	841157367.393	17008857.311	0.537	-0.897	0.005	0.014
12,13-DHOME	1.475	37947022.226	3504312.496	91611322.698	6174124.035	0.414	-1.272	0.005	0.014
15-Deoxy-d-12,14-PGJ2	1.487	94961472.526	5290990.308	29393681.872	2276273.523	3.231	1.692	0.005	0.014
Sphingosine	1.411	17036824.571	2013317.633	25982400.543	1397919.597	0.656	-0.609	0.005	0.014
Sphinganine	1.296	332549186.759	14712296.538	442497741.130	46982097.536	0.752	-0.412	0.005	0.014
Quercetin	1.472	308564755.490	6228857.435	408319201.305	12669298.911	0.756	-0.404	0.005	0.014
2,3-Dinor-8-iso prostaglandin F2alpha	1.305	96173944.464	17528195.096	139769034.207	7172311.810	0.688	-0.539	0.005	0.014
13(S)-HpOTrE	1.423	283026553.946	7481262.734	248625351.951	4424229.666	1.138	0.187	0.005	0.014
9,10-12,13-Diepoxyoctadecanoate	1.402	35831367.087	4356739.992	57673797.760	4562883.452	0.621	-0.687	0.005	0.014
5(S)-HpETE	1.360	41724426.052	5789091.413	17922893.941	6201013.484	2.328	1.219	0.005	0.014
9(S)-HPETE	1.304	34012046.437	11662434.640	6489415.770	2891453.257	5.241	2.390	0.005	0.014
8,9-EET	1.432	51748248.702	1393148.679	42870452.843	1560530.961	1.207	0.272	0.005	0.014
5,6-DHET	1.463	40388837.428	4504791.198	5960641.399	3638191.617	6.776	2.760	0.005	0.014
3-CMP	1.276	51661041.619	3881570.926	65731418.254	5429038.581	0.786	-0.348	0.005	0.014
Senecionine	1.401	25860386.416	2863746.473	35884300.294	585518.071	0.721	-0.473	0.005	0.014
8-Isoprostane	1.443	34489491.900	837090.676	19808321.126	3019359.990	1.741	0.800	0.005	0.014
dGMP	1.319	7690118.540	1542331.266	11869982.816	798531.769	0.648	-0.626	0.005	0.014
Prostaglandin G2	1.436	1076362703.764	35635633.886	1280763620.696	29870147.574	0.840	-0.251	0.005	0.014
Prostaglandin I2	1.492	331541433.620	8913801.977	129629650.588	9524968.611	2.558	1.355	0.005	0.014
Chlorogenic acid	1.433	57374109.783	6091510.034	25434213.699	4265181.619	2.256	1.174	0.005	0.014
Chelirubine	1.267	28669840.197	8158574.520	6901841.326	6784103.574	4.154	2.054	0.005	0.014
GMP	1.315	30624078.697	12449217.010	86049585.444	19725137.858	0.356	-1.490	0.005	0.014
Riboflavin	1.350	174920101.962	18138611.805	335758583.910	56909291.323	0.521	-0.941	0.005	0.014
Desmosterol	1.127	3321004.612	2169439.924	6650889.751	605283.907	0.499	-1.002	0.005	0.014
Calcitriol	1.466	26754239.439	1310774.119	6183373.178	3022628.960	4.327	2.113	0.005	0.014
Amygdalin	1.377	11122532.206	2757899.964	1998373.510	1193556.541	5.566	2.477	0.005	0.014
Rutin	1.466	1258748008.857	116749999.632	2084981939.839	58935909.745	0.604	-0.728	0.005	0.014
2-Phenylacetamide	1.182	809550790.752	20503117.984	769092332.682	13136646.185	1.053	0.074	0.008	0.021
Acetylphosphate	1.086	113189493.181	42779446.979	46428609.507	23999360.470	2.438	1.286	0.008	0.021
Coumarin	1.163	151691341.020	6579799.049	139845264.651	3472264.063	1.085	0.117	0.008	0.021
Prostaglandin-c2	1.208	164379953.645	7787393.932	148550710.038	4434881.393	1.107	0.146	0.008	0.021
Salicylic acid	1.086	51416892.968	6870720.473	39016566.715	5984246.617	1.318	0.398	0.013	0.030
L-Lysine	1.194	719165085.769	27133936.544	656247753.433	24970686.729	1.096	0.132	0.013	0.030
Guanine	1.190	1028235026.839	55110542.015	1255514620.174	122522022.791	0.819	-0.288	0.013	0.030
Aminoadipic acid	1.023	59812806.502	5881778.639	51752408.091	3134356.503	1.156	0.209	0.013	0.030
D-Phenyllactic acid	1.146	41589965.388	4868248.548	26622657.122	8431804.383	1.562	0.644	0.013	0.030
L-Arginine	1.114	607660616.153	32493906.705	491176566.881	74110265.572	1.237	0.307	0.013	0.030
Diaminopimelic acid	1.100	58185150.542	2231228.828	62966694.369	2590519.043	0.924	-0.114	0.013	0.030
Cytidine	1.173	985907272.287	35912255.949	1100150784.412	60284092.740	0.896	-0.158	0.013	0.030
Prostaglandin D2	1.088	15208618.908	7767466.335	3825849.719	3017743.755	3.975	1.991	0.013	0.030
11,12,15-THETA	1.097	5069094.494	1551592.463	18308335.977	9388526.378	0.277	-1.853	0.013	0.030
Maleic acid	1.086	27719017.177	16382479.551	4913433.204	3576085.790	5.641	2.496	0.020	0.043
Ascorbate	1.258	50676996.544	17747854.447	12191034.644	7404987.747	4.157	2.055	0.020	0.043
Dodecanoic acid	1.010	78779642.594	14377498.431	102353874.809	13860893.743	0.770	-0.378	0.031	0.059
3-[(1-Carboxyvinyl)oxy]benzoate	1.214	100893053.148	34369957.524	32664424.715	16515627.908	3.089	1.627	0.031	0.059
L-Kynurenine	1.132	17344128.191	6784928.161	6262127.868	2998840.519	2.770	1.470	0.031	0.059
Stearidonic acid	1.030	645740215.230	197225380.330	318877616.759	180195823.177	2.025	1.018	0.031	0.059
4-Hydroxycinnamic acid	1.124	20893904.631	1643473.682	9278243.341	7731462.365	2.252	1.171	0.045	0.081
Pyruvic acid	1.269	246401890.953	6012539.013	340425197.641	45507984.293	0.724	-0.466	0.005	0.014
Malonate	1.400	35112239.838	3677492.489	16839292.011	4016431.219	2.085	1.060	0.005	0.014
Dihydrouracil	1.113	6297182.978	754108.499	14578365.347	5750041.816	0.432	-1.211	0.005	0.014
Fumaric acid	1.455	42339782.095	2728988.374	60726149.441	2324427.795	0.697	-0.520	0.005	0.014
Phenylethylamine	1.463	59789645.660	2608193.955	42104612.406	1715018.680	1.420	0.506	0.005	0.014
Adenine	1.483	2318561649.751	168416410.430	802044824.396	68010889.669	2.891	1.532	0.005	0.014
L-Glutamic acid	1.375	102857385.856	6891986.901	135817825.017	8733257.999	0.757	-0.401	0.005	0.014
3-Hydroxyanthranilic acid	1.461	8959046.281	668210.146	4460942.151	463879.484	2.008	1.006	0.005	0.014
Gentisic acid	1.430	60221118.411	12986504.617	7006575.218	1338501.197	8.595	3.103	0.005	0.014
Phenylpyruvic acid	1.482	35837140.562	1006294.748	23626452.975	1110355.385	1.517	0.601	0.005	0.014
Kynurenic acid	1.480	15680730.537	789417.523	9240737.442	275186.378	1.697	0.763	0.005	0.014
Quinate	1.428	9926384909.776	545953479.896	14051053509.383	875090810.363	0.706	-0.501	0.005	0.014
trans-Ferulic acid	1.497	58183935.893	1513218.733	27353767.196	451365.283	2.127	1.089	0.005	0.014
L-Tryptophan	1.416	791368369.025	38477205.082	586750518.044	40063931.061	1.349	0.432	0.005	0.014
N-Acetyl-L-phenylalanine	1.491	98213809.816	4950589.104	24495564.728	4049400.021	4.010	2.003	0.005	0.014
L-Cystine	1.321	169061831.054	90077991.052	452800256.487	76875625.714	0.373	-1.421	0.005	0.014
Galactosylglycerol	1.451	91335576.819	11425203.024	18093178.387	9499455.115	5.048	2.336	0.005	0.014
2-O-(alpha-D-Mannosyl)-D-glycerate	1.397	22026964.194	1353959.437	13947347.257	2044575.574	1.579	0.659	0.005	0.014
Inosine	1.440	846653.253	223180.821	18610747.356	4006199.586	0.045	-4.458	0.005	0.014
13(S)-HOT	1.489	1897660951.679	77398443.115	981183682.733	37202024.504	1.934	0.952	0.005	0.014
Guanosine	1.499	17258453.502	994860.948	150333166.469	4293196.974	0.115	-3.123	0.005	0.014
Prunasin	1.313	10835223.356	898090.079	8196458.266	687181.548	1.322	0.403	0.005	0.014
Ribose 1,5-bisphosphate	1.251	86537524.610	18857082.227	45401318.057	9454846.443	1.906	0.931	0.005	0.014
Melibiitol	1.381	7909227.721	1778491.716	2339244.509	438569.347	3.381	1.758	0.005	0.014
p-Coumaroyl quinic acid	1.480	95332704.641	4704897.747	55716074.951	2059982.527	1.711	0.775	0.005	0.014
Cyclic GMP	1.461	21090706.127	946984.793	43325832.279	3908203.212	0.487	-1.039	0.005	0.014
Prostaglandin H2	1.366	59936214.686	2572559.746	47115010.449	3712252.467	1.272	0.347	0.005	0.014
Xanthohumol	1.488	25211266.313	1849480.987	5833373.271	508477.722	4.322	2.112	0.005	0.014
Geniposidic acid	1.432	24493995.795	1917293.157	14812400.952	1351303.097	1.654	0.726	0.005	0.014
Succinic acid	1.057	1790586.503	1833450.860	11016263.933	6960824.655	0.163	-2.621	0.013	0.030
Trehalose	1.055	42473350.581	17753426.407	15981050.522	10771289.038	2.658	1.410	0.020	0.043
Chitobiose	1.143	27523197.202	1843481.232	23981735.475	1428213.348	1.148	0.199	0.020	0.043
Urocanic acid	1.182	4552149.150	1758237.545	13370844.393	5040920.433	0.340	-1.554	0.031	0.060
Dhurrin	1.093	36990702.484	16606545.710	13677621.793	3526676.738	2.704	1.435	0.045	0.082
Deacetylvindoline	1.008	45783112.764	16324007.771	24190553.520	8555516.893	1.893	0.920	0.045	0.082

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值