差异代谢物筛选

通过对代谢物进行筛选,寻找差异代谢物(biomarker)。相关差异代谢物筛选条件有:

  1. p-value ≤ 0.05 且 VIP ≥ 1[1]
  2. p-value ≤ 0.05 且 fold_change ≥ 1.5或≤0.667[2]
  3. one-way ANOVA p-value ≤ 0.05[3]
  4. two-way ANOVA p-value ≤ 0.05[4]
详细含义:

筛选值 筛选值含义 筛选阈值 备注
p-value 统计学上显著差异 p-value ≤ 0.05
VIP OPLS-DA第一主成分变量重要性值投影 VIP ≥ 1
Fold change 两两组别间倍性变化 fold_change ≥1.5或≤0.667 含量差异较大
one-way ANOVA p-value 一维方差分析 p-value ≤ 0.05 主要用于时间序列,梯度浓度处理等
two-way ANOVA p-value 两因素方差分析 p-value ≤ 0.05 一般为两因素情况,如对照-处理+时间序列样本
本实验采用条件 1 进行代谢物筛选,最终获得的差异代谢物见下表:

差异信息汇总信息
  dam_DEG.xlsx(正离子模式)
dam_DEG.xlsx 包含“stats”和“ALL_DEG.xlsx”两个工作簿,其中“stats”统计了各个比对组别差异代谢物的上、下调情况,“ALL_DEG”汇总了所有比对组别的差异代谢物信息。


mz rt rtmin BCG vs MG vs FZG vs RSG vs FZRSG_VIP p.value FDR
M217T211 217.243 211.409 3.520 1.987 0.000 0.000
M410T308 410.185 307.711 5.130 2.009 0.000 0.000
M261T243_3 261.130 242.517 4.040 2.018 0.000 0.000
M277T243 277.104 242.567 4.040 1.997 0.000 0.000
M262T243 262.133 242.558 4.040 2.023 0.000 0.000
M321T267 321.130 267.403 4.460 2.048 0.000 0.000
M454T324 454.211 324.250 5.400 1.978 0.000 0.000
M498T339 498.237 338.864 5.650 1.923 0.000 0.000
M409T307 409.182 307.398 5.120 2.024 0.000 0.000
M365T289 365.156 288.583 4.810 2.051 0.000 0.000
M497T339 497.233 338.722 5.650 1.892 0.000 0.000
M233T212 233.078 211.543 3.530 2.004 0.000 0.000
M542T352 542.263 351.604 5.860 2.059 0.000 0.000
M306T267 306.159 267.441 4.460 2.061 0.000 0.000
M218T212 218.107 211.949 3.530 1.990 0.000 0.000
M217T212_3 217.105 211.860 3.530 2.027 0.000 0.000
M239T244_3 239.148 243.568 4.060 1.993 0.000 0.000
M453T324 453.208 323.905 5.400 2.073 0.000 0.000
M305T267_2 305.155 267.403 4.460 2.059 0.000 0.000
M256T243_2 256.175 242.570 4.040 1.830 0.000 0.000
M240T244 240.152 243.568 4.060 1.962 0.000 0.000
M195T213_3 195.122 212.712 3.550 1.917 0.000 0.000
M196T213 196.126 212.759 3.550 1.931 0.000 0.000
M284T243 284.206 243.262 4.050 1.865 0.000 0.000
M300T267_4 300.200 267.427 4.460 1.864 0.000 0.000
M257T243 257.178 242.665 4.040 1.863 0.000 0.000
M263T243 263.134 242.664 4.040 2.093 0.000 0.000
M301T267 301.204 267.435 4.460 1.867 0.000 0.000
M541T352_2 541.259 351.604 5.860 2.035 0.000 0.000
M261T281 261.130 280.911 4.680 1.837 0.000 0.000
M261T243_1 260.946 242.716 4.050 1.975 0.000 0.000
M305T268_1 305.077 267.503 4.460 2.076 0.000 0.000
M283T267_2 283.174 267.457 4.460 2.006 0.000 0.000
M389T307_2 389.256 307.243 5.120 1.927 0.000 0.000
M217T212_1 216.964 211.859 3.530 2.038 0.000 0.000
M305T300 305.156 300.490 5.010 1.990 0.000 0.000
M586T364 586.289 363.913 6.070 2.039 0.000 0.000
M388T307_4 388.253 307.326 5.120 1.934 0.000 0.000
M212T212 212.149 211.683 3.530 1.860 0.000 0.000
M344T289_4 344.227 288.583 4.810 1.990 0.000 0.000
M345T289_2 345.230 288.597 4.810 1.999 0.000 0.000
M433T324 433.282 323.750 5.400 1.879 0.000 0.000
M432T324_2 432.279 323.804 5.400 1.871 0.000 0.000
M348T385 348.164 385.160 6.420 2.186 0.000 0.000
M349T289_3 349.181 288.599 4.810 2.044 0.000 0.000
M394T307_2 394.211 307.299 5.120 1.905 0.000 0.000
M477T338_2 477.308 338.200 5.640 1.735 0.000 0.000
M476T338_5 476.305 338.158 5.640 1.730 0.000 0.000
M585T364_2 585.285 363.913 6.070 1.947 0.000 0.000
M350T289 350.185 288.569 4.810 2.076 0.000 0.000
M393T307_3 393.207 307.272 5.120 1.944 0.000 0.000
M346T385_1 345.686 385.134 6.420 1.857 0.000 0.000
M316T375_1 315.687 374.866 6.250 1.991 0.000 0.000
M630T374 630.315 374.438 6.240 2.116 0.000 0.000
M201T260 201.109 260.171 4.340 1.853 0.000 0.000
M338T385_2 338.201 385.134 6.420 1.992 0.000 0.000
M296T364 296.151 363.913 6.070 2.153 0.000 0.000
M338T385_1 337.699 385.183 6.420 1.993 0.000 0.000
M393T307_6 393.320 307.020 5.120 1.921 0.000 0.000
M980T267 979.824 267.368 4.460 1.958 0.000 0.000
M326T375 326.151 374.770 6.250 2.220 0.000 0.000
M629T375 629.311 374.584 6.240 2.074 0.000 0.000
M674T384 674.341 384.436 6.410 2.110 0.000 0.000
M219T212 219.108 211.508 3.530 2.233 0.000 0.000
M366T289 366.159 288.541 4.810 1.977 0.000 0.000
M195T213_4 195.161 212.757 3.550 1.797 0.000 0.000
M341T385_1 340.679 385.031 6.420 2.154 0.000 0.000
M673T385 673.337 384.794 6.410 2.124 0.000 0.000
M318T375 318.164 374.839 6.250 2.158 0.000 0.000
M351T288 351.186 288.495 4.810 2.123 0.000 0.000
M319T375 318.666 374.774 6.250 2.170 0.000 0.000
M481T338_4 481.259 337.779 5.630 1.852 0.000 0.000
M482T338 482.263 337.805 5.630 1.862 0.000 0.000
M335T385 335.222 385.114 6.420 1.807 0.000 0.000
M521T352_4 521.334 351.594 5.860 1.818 0.000 0.000
M522T352 522.336 351.598 5.860 1.655 0.000 0.000
M370T394 370.177 393.979 6.570 2.152 0.000 0.000
M520T352_5 520.330 351.604 5.860 1.854 0.000 0.000
M455T324 455.206 324.021 5.400 1.970 0.000 0.000
M305T267_1 304.923 267.460 4.460 2.114 0.000 0.000
M108T330 107.966 330.026 5.500 2.061 0.000 0.000
M437T324_2 437.233 323.804 5.400 2.028 0.000 0.000
M438T324 438.237 323.798 5.400 2.032 0.000 0.000
M439T324 439.239 323.799 5.400 2.065 0.000 0.000
M336T385_1 335.724 385.070 6.420 1.684 0.000 0.000
M308T897 308.294 897.286 14.950 2.335 0.000 0.000
M360T394_1 359.712 394.017 6.570 2.009 0.000 0.000
M567T244 567.257 243.767 4.060 2.028 0.000 0.000
M284T267 284.178 267.471 4.460 1.940 0.000 0.000
M980T288 979.823 288.386 4.810 2.051 0.000 0.000
M352T375 352.158 374.591 6.240 2.101 0.000 0.000
M362T394 362.190 393.999 6.570 2.118 0.000 0.000
M368T394_1 367.699 393.969 6.570 2.086 0.000 0.000
M566T363 566.362 363.337 6.060 1.844 0.000 0.000
M360T394_2 360.214 393.999 6.570 2.076 0.000 0.000
M309T897 309.298 897.141 14.950 2.297 0.000 0.000
M327T289_3 327.200 288.608 4.810 1.994 0.000 0.000
M187T217 187.094 217.159 3.620 1.754 0.000 0.000
M565T364 565.360 363.521 6.060 1.904 0.000 0.000
M285T268 285.180 267.503 4.460 1.999 0.000 0.000
M301T314 300.700 313.811 5.230 1.980 0.000 0.000
M718T394 718.366 393.917 6.570 2.161 0.000 0.000
M213T213 213.152 212.671 3.540 1.883 0.000 0.000
M750T288 750.178 288.283 4.800 1.617 0.000 0.000
M564T364_2 564.356 363.632 6.060 1.913 0.000 0.000
M593T267 592.733 267.407 4.460 2.018 0.000 0.000
M717T394 717.363 393.918 6.570 2.121 0.000 0.000
M363T394_1 362.691 393.979 6.570 2.078 0.000 0.000
M235T212 235.076 212.180 3.540 1.589 0.000 0.000
M655T341 654.796 340.669 5.680 1.935 0.000 0.000
M271T887 271.282 887.433 14.790 2.320 0.000 0.000
M608T374_3 608.383 373.945 6.230 1.982 0.000 0.000
M197T213 197.127 212.825 3.550 1.869 0.000 0.000
M609T374_3 609.386 373.644 6.230 1.950 0.000 0.000
M361T394_1 360.715 393.917 6.570 2.093 0.000 0.000
M526T352_3 526.288 351.594 5.860 2.036 0.000 0.000
M565T363_1 564.550 363.219 6.050 1.845 0.000 0.000
M278T243 278.107 243.389 4.060 1.847 0.000 0.000
M525T352_2 525.284 351.594 5.860 2.043 0.000 0.000
M610T374 610.389 373.615 6.230 1.918 0.000 0.000
M357T394 357.235 394.005 6.570 1.963 0.000 0.000
M371T307_2 371.227 307.234 5.120 1.911 0.000 0.000
M173T99 173.078 99.445 1.660 1.718 0.000 0.000
M543T352 543.260 351.612 5.860 1.664 0.000 0.000
M307T267 307.161 267.463 4.460 1.897 0.000 0.000
M657T384 657.364 384.190 6.400 2.107 0.000 0.000
M569T363_3 569.310 363.389 6.060 2.118 0.000 0.000
M658T384 658.367 383.724 6.400 2.115 0.000 0.000
M313T375 313.209 374.770 6.250 1.462 0.000 0.000
M570T363_3 570.314 363.155 6.050 2.063 0.000 0.000
M358T394_1 357.737 393.984 6.570 1.967 0.000 0.000
M294T364 293.674 363.968 6.070 2.122 0.000 0.000
M980T323 979.824 322.685 5.380 1.983 0.000 0.000
M613T374_3 613.337 373.868 6.230 2.088 0.000 0.000
M653T384 653.412 383.683 6.390 1.900 0.000 0.000
M652T384_2 652.409 384.040 6.400 1.993 0.000 0.000
M527T352 527.291 351.506 5.860 1.996 0.000 0.000
M659T384 659.369 383.832 6.400 2.191 0.000 0.000
M614T374_2 614.341 373.630 6.230 2.059 0.000 0.000
M571T362 571.317 362.465 6.040 2.028 0.000 0.000
M593T323 592.733 322.543 5.380 2.266 0.000 0.000
M644T340_1 643.805 339.971 5.670 2.043 0.000 0.000
M681T374 681.325 374.253 6.240 1.895 0.000 0.000
M980T306 979.823 306.436 5.110 1.838 0.000 0.000
M750T267 750.178 267.425 4.460 1.644 0.000 0.000
M336T385_2 336.225 384.912 6.420 1.765 0.000 0.000
M750T306 750.178 306.436 5.110 1.815 0.000 0.000
M382T403_1 381.726 402.825 6.710 2.079 0.000 0.000
M701T394 701.390 393.918 6.570 2.148 0.000 0.000
M346T385_2 346.188 385.144 6.420 2.228 0.000 0.000
M279T243 279.102 243.065 4.050 1.874 0.000 0.000
M338T367 338.162 367.385 6.120 1.824 0.000 0.000
M187T288_3 186.601 288.053 4.800 1.332 0.000 0.000
M328T289 328.204 288.611 4.810 1.900 0.000 0.000
M368T394_2 368.201 393.964 6.570 2.079 0.000 0.000
M411T308 411.180 307.773 5.130 1.883 0.000 0.000
M336T367 335.684 367.315 6.120 1.823 0.000 0.000
M374T385 374.171 385.141 6.420 2.016 0.000 0.000
M396T394 396.184 393.979 6.570 2.195 0.000 0.000
M761T402 761.389 402.131 6.700 2.131 0.000 0.000
M158T96 158.092 95.608 1.590 1.585 0.000 0.000
M151T132 151.096 132.493 2.210 1.195 0.000 0.000
M384T403 384.203 402.825 6.710 2.156 0.000 0.000
M305T374 304.696 373.607 6.230 1.888 0.000 0.000
M702T394 702.393 393.671 6.560 2.045 0.000 0.000
M317T375 316.689 374.946 6.250 2.028 0.000 0.000
M302T267 302.206 267.490 4.460 1.561 0.000 0.000
M382T403_2 382.227 402.815 6.710 2.026 0.000 0.000
M173T74 173.078 74.418 1.240 1.538 0.000 0.000
M750T323 750.178 322.670 5.380 2.079 0.000 0.000
M195T213_5 195.241 212.758 3.550 2.136 0.000 0.000
M367T289 367.154 288.608 4.810 1.717 0.000 0.000
M392T402 392.190 402.457 6.710 2.177 0.000 0.000
M159T280_2 159.065 279.803 4.660 1.655 0.000 0.000
M329T384 329.186 383.685 6.390 2.015 0.000 0.000
M644T340_2 644.307 339.699 5.660 1.891 0.000 0.000
M327T384 326.709 383.682 6.390 1.973 0.000 0.000
M697T377 697.358 377.373 6.290 1.785 0.000 0.000
M609T356 609.306 356.222 5.940 1.815 0.000 0.000
M745T402 745.416 402.321 6.710 2.099 0.000 0.000
M615T374 615.343 373.642 6.230 2.082 0.000 0.000
M177T268 177.112 267.503 4.460 1.784 0.000 0.000
M301T258 301.140 257.504 4.290 1.740 0.000 0.000
M159T330 158.962 329.879 5.500 1.920 0.000 0.000
M604T356 604.351 356.213 5.940 1.805 0.000 0.000
M390T307 390.258 307.368 5.120 1.646 0.000 0.000
M593T288 592.733 288.453 4.810 1.703 0.000 0.000
M385T403_1 384.705 402.532 6.710 2.130 0.000 0.000
M415T323_2 415.253 322.977 5.380 1.817 0.000 0.000
M587T364 587.282 363.928 6.070 2.310 0.000 0.000
M416T323 416.256 322.900 5.380 1.829 0.000 0.000
M653T367 653.332 367.315 6.120 1.757 0.000 0.000
M358T378 357.697 377.527 6.290 1.753 0.000 0.000
M307T374 307.173 373.604 6.230 2.040 0.000 0.000
M114T259 114.091 258.806 4.310 2.324 0.000 0.000
M789T410 789.441 410.426 6.840 2.234 0.000 0.000
M304T364 304.138 363.989 6.070 2.197 0.000 0.000
M746T402 746.419 402.339 6.710 2.113 0.000 0.000
M187T288_4 186.617 288.094 4.800 1.633 0.000 0.000
M593T306 592.733 306.436 5.110 1.845 0.000 0.000
M654T384 654.415 383.685 6.390 1.873 0.000 0.000
M404T411 403.739 410.784 6.850 2.023 0.000 0.000
M344T747 344.227 747.120 12.450 1.859 0.000 0.000
M404T410_2 404.240 410.354 6.840 2.081 0.000 0.000
M434T324 434.284 323.846 5.400 1.486 0.000 0.000
M703T394 703.395 393.947 6.570 1.953 0.000 0.000
M418T403 418.197 402.635 6.710 2.124 0.000 0.000
M372T307 372.230 307.080 5.120 1.841 0.000 0.000
M323T267 323.128 267.454 4.460 1.898 0.000 0.000
M244T247 243.684 247.022 4.120 1.795 0.000 0.000
M136T259 136.073 258.782 4.310 2.104 0.000 0.000
M339T385_1 338.703 384.948 6.420 1.789 0.000 0.000
M379T403 379.248 402.820 6.710 1.844 0.000 0.000
M330T384 329.688 383.683 6.390 1.974 0.000 0.000
M385T403_2 385.206 402.639 6.710 1.897 0.000 0.000
M241T244 241.153 243.718 4.060 1.788 0.000 0.000
M157T227 157.084 227.161 3.790 1.900 0.000 0.000
M349T289_1 349.086 288.583 4.810 1.869 0.000 0.000
M980T242 979.824 242.154 4.040 2.094 0.000 0.000
M459T337_2 459.279 337.358 5.620 1.736 0.000 0.000
M327T659 327.200 659.471 10.990 2.020 0.000 0.000
M696T394 696.435 393.872 6.560 2.039 0.000 0.000
M565T363_2 564.940 363.253 6.050 1.483 0.000 0.000
M388T601 388.253 601.388 10.020 1.047 0.000 0.000
M324T375 323.673 374.543 6.240 2.004 0.000 0.000
M261T243_5 261.191 242.558 4.040 1.611 0.000 0.000
M790T411 790.444 410.736 6.850 2.134 0.000 0.000
M390T402_1 389.712 402.330 6.710 1.925 0.000 0.000
M308T374 307.675 373.607 6.230 2.054 0.000 0.000
M698T377 698.361 377.067 6.280 1.668 0.000 0.000
M806T411 806.418 410.642 6.840 2.166 0.000 0.000
M360T377 360.175 377.151 6.290 1.750 0.000 0.000
M725T384 725.350 383.688 6.390 2.129 0.000 0.000
M407T410_1 406.718 410.426 6.840 2.249 0.000 0.000
M521T243 521.251 243.389 4.060 1.619 0.000 0.000
M113T89 113.021 89.403 1.490 1.556 0.000 0.000
M247T91 247.016 91.068 1.520 1.515 0.000 0.000
M328T268 328.232 267.865 4.460 1.331 0.000 0.000
M762T403 762.392 402.709 6.710 2.090 0.000 0.000
M697T393 697.438 393.353 6.560 2.030 0.000 0.000
M330T364 330.145 363.988 6.070 1.825 0.000 0.000
M406T410 406.216 410.422 6.840 2.177 0.000 0.000
M390T402_2 390.214 402.298 6.700 1.945 0.000 0.000
M632T374 632.312 374.173 6.240 2.012 0.000 0.000
M483T338 483.265 337.760 5.630 1.697 0.000 0.000
M349T393 349.224 393.353 6.560 1.940 0.000 0.000
M234T91 233.982 90.810 1.510 1.847 0.000 0.000
M258T243 258.180 242.587 4.040 1.841 0.000 0.000
M648T367 648.377 367.400 6.120 1.807 0.000 0.000
M172T289 171.789 288.548 4.810 2.152 0.000 0.000
M241T258 241.068 257.897 4.300 1.750 0.000 0.000
M380T387 380.212 387.119 6.450 1.794 0.000 0.000
M261T243_6 261.313 242.517 4.040 1.835 0.000 0.000
M327T692 327.200 691.966 11.530 2.239 0.000 0.000
M401T410 401.261 410.422 6.840 1.946 0.000 0.000
M243T247 243.182 247.037 4.120 1.627 0.000 0.000
M318T384 318.195 383.645 6.390 2.039 0.000 0.000
M285T362 285.160 362.310 6.040 2.004 0.000 0.000
M377T388 377.232 387.531 6.460 1.800 0.000 0.000
M740T402 740.461 401.689 6.690 2.005 0.000 0.000
M564T364_1 564.333 363.597 6.060 1.804 0.000 0.000
M187T323_3 186.630 322.808 5.380 1.580 0.000 0.000
M296T374 296.182 373.598 6.230 1.956 0.000 0.000
M173T156 173.078 155.528 2.590 1.626 0.000 0.000
M380T403_1 379.750 402.517 6.710 1.884 0.000 0.000
M358T394_2 358.238 393.964 6.570 1.509 0.000 0.000
M747T403 747.421 402.505 6.710 2.166 0.000 0.000
M742T402 742.466 401.875 6.700 2.039 0.000 0.000
M322T267 322.133 267.454 4.460 1.859 0.000 0.000
M583T244 583.230 243.772 4.060 2.338 0.000 0.000
M349T394 348.722 393.722 6.560 1.969 0.000 0.000
M347T749 347.218 749.368 12.490 2.174 0.000 0.000
M805T410 805.415 410.424 6.840 2.118 0.000 0.000
M172T267_7 171.790 267.397 4.460 2.423 0.000 0.000
M414T411 414.203 410.521 6.840 2.131 0.000 0.000
M187T267_2 186.579 267.369 4.460 1.507 0.000 0.000
M693T377 693.406 377.062 6.280 1.694 0.000 0.000
M345T289_1 344.505 288.608 4.810 1.688 0.000 0.000
M314T375 313.711 374.503 6.240 1.276 0.000 0.000
M351T394 351.199 393.754 6.560 2.008 0.000 0.000
M108T299 107.966 299.113 4.990 1.912 0.000 0.000
M402T410_1 401.763 410.393 6.840 1.834 0.000 0.000
M478T338 478.310 338.348 5.640 1.631 0.000 0.000
M352T393 351.701 393.409 6.560 1.979 0.000 0.000
M503T351 503.304 350.810 5.850 1.962 0.000 0.000
M142T280 141.958 279.747 4.660 1.599 0.000 0.000
M239T230 239.088 230.308 3.840 1.597 0.000 0.000
M315T374 315.160 373.598 6.230 2.137 0.000 0.000
M393T629 393.208 628.664 10.480 1.526 0.000 0.000
M213T307 213.077 306.625 5.110 1.725 0.000 0.000
M349T747 349.182 746.925 12.450 1.554 0.000 0.000
M99T280 99.080 279.803 4.660 1.712 0.000 0.000
M183T280 182.985 279.666 4.660 1.761 0.000 0.000
M187T323_1 186.566 322.526 5.380 1.667 0.000 0.000
M397T394 396.685 393.852 6.560 1.359 0.000 0.000
M151T157 151.096 156.578 2.610 1.581 0.000 0.000
M349T289_6 349.465 288.541 4.810 1.831 0.000 0.000
M297T374 296.684 373.604 6.230 1.952 0.000 0.000
M419T403 418.699 402.505 6.710 2.038 0.000 0.000
M741T402 741.464 401.517 6.690 1.933 0.000 0.000
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M541T259_1 540.754 259.077 4.320 1.067 0.023 0.065
M332T687 332.315 687.409 11.460 1.209 0.024 0.066
M705T720 704.575 720.120 12.000 1.255 0.024 0.067
M587T420_1 586.832 420.164 7.000 1.024 0.025 0.068
M525T793_1 524.800 793.231 13.220 1.268 0.025 0.069
M449T425 448.768 424.764 7.080 1.242 0.025 0.070
M846T553 846.255 552.552 9.210 1.188 0.026 0.071
M301T80 301.140 79.914 1.330 1.038 0.026 0.072
M625T483_1 624.712 482.583 8.040 1.121 0.026 0.072
M341T838 341.247 837.716 13.960 1.250 0.027 0.073
M116T103 116.070 103.236 1.720 1.126 0.027 0.073
M874T425 873.540 424.777 7.080 1.275 0.027 0.073
M478T419 478.226 419.137 6.990 1.121 0.027 0.074
M620T426 619.811 425.790 7.100 1.001 0.029 0.079
M756T474 755.779 473.842 7.900 1.062 0.029 0.079
M112T748_1 111.522 747.997 12.470 1.103 0.029 0.079
M630T483 630.387 483.491 8.060 1.203 0.029 0.079
M489T438 489.313 437.766 7.300 1.248 0.030 0.080
M779T384 779.318 383.570 6.390 1.010 0.030 0.081
M225T424 225.019 423.529 7.060 1.141 0.031 0.082
M454T441 454.283 440.781 7.350 1.223 0.031 0.082
M585T420_1 584.856 420.115 7.000 1.158 0.032 0.084
M555T71 554.796 70.639 1.180 1.225 0.032 0.084
M504T488 503.531 488.082 8.130 1.144 0.032 0.086
M523T409 523.302 408.524 6.810 1.129 0.032 0.086
M794T460 793.938 459.949 7.670 1.258 0.033 0.086
M564T661 564.377 660.994 11.020 1.184 0.033 0.087
M662T489_2 662.058 488.540 8.140 1.149 0.033 0.088
M847T552 846.656 552.249 9.200 1.224 0.034 0.088
M886T523_1 885.938 523.118 8.720 1.177 0.036 0.093
M142T174 141.958 173.984 2.900 1.258 0.036 0.095
M290T683 290.295 682.933 11.380 1.190 0.037 0.095
M229T69 229.154 69.291 1.150 1.118 0.037 0.096
M459T254 459.205 254.447 4.240 1.250 0.038 0.097
M349T59 348.989 59.148 0.990 1.124 0.039 0.099
M352T855 352.320 855.234 14.250 1.161 0.039 0.099
M674T491 674.412 491.172 8.190 1.087 0.039 0.101
M147T4 147.065 4.461 0.070 1.225 0.040 0.103
M682T495_1 681.659 495.242 8.250 1.208 0.040 0.103
M897T522_1 896.982 521.668 8.690 1.023 0.041 0.104
M837T468_2 837.462 467.655 7.790 1.125 0.041 0.105
M142T226 141.958 226.434 3.770 1.171 0.042 0.106
M173T629 173.078 628.825 10.480 1.114 0.043 0.108
M481T438 480.800 437.826 7.300 1.213 0.043 0.108
M173T661 173.078 661.159 11.020 1.127 0.043 0.109
M187T119 186.580 119.409 1.990 1.223 0.044 0.109
M528T460 528.329 460.197 7.670 1.146 0.044 0.110
M189T60 189.159 59.675 0.990 1.058 0.044 0.110
M750T883 750.178 882.841 14.710 1.031 0.045 0.112
M897T522_2 897.484 521.668 8.690 1.068 0.046 0.114
M254T6 253.909 5.650 0.090 1.050 0.047 0.115
M106T69 106.086 68.528 1.140 1.177 0.047 0.117
M547T787 547.357 786.913 13.120 1.033 0.048 0.119
M499T452 498.978 452.092 7.530 1.127 0.049 0.120
M141T8 141.127 7.580 0.130 1.144 0.049 0.121
mz:质核比;rt:保留时间(以秒为单位);rtmin:保留时间(以分钟为单位);*_VIP:VIP值;mean_*:平均值;sd_*:标准差;fold change:倍性变化;log2(FC):倍性变化的log2值;pvalue:统计学p值;FDR:pvalue校正值
以下为差异待鉴定代谢物统计结果:
图:差异代谢物统计柱状图

代谢物上下调关系

  updownstats.csv