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MSMSfinal_DEM.xlsx 里面包含每个比对组别鉴定的差异代谢物的统计信息和汇总表格。

本实验中所得差异代谢物的统计分析结果见下表：

Z vs M
Z vs X
Z vs L
Z vs H
Z vs A
M vs X vs Z
L vs M vs Z
H vs M vs Z
A vs M vs Z

	VIP	mean_Z	sd_Z	mean_M	sd_M	Fold Change_Z/M	log2(FC_Z/M)	p.value	FDR
Choline	1.063	23.648	11.839	866.802	1641.837	0.027	-5.196	0.000	0.058
Phosphonoacetate	1.546	2.199	1.969	87.315	102.721	0.025	-5.311	0.000	0.058
L-Glutamine	2.386	23.882	2.749	31.707	2.281	0.753	-0.409	0.001	0.058
5-Methylcytosine	2.408	726.512	82.548	494.518	58.985	1.469	0.555	0.001	0.058
1H-Indole-3-acetamide	1.703	19.214	9.525	8.643	2.264	2.223	1.153	0.001	0.069
Ciliatine	1.791	0.576	0.759	5.118	4.279	0.113	-3.151	0.001	0.073
(R) 2,3-Dihydroxy-3-methylvalerate	1.325	1.240	1.098	0.399	0.112	3.104	1.634	0.002	0.082
gamma-Glutamylalanine	1.747	7.796	3.127	15.599	6.964	0.500	-1.001	0.002	0.089
1-Aminocyclopropanecarboxylic acid	2.086	61.105	6.943	48.227	4.835	1.267	0.341	0.003	0.094
Indole-3-acetaldehyde oxime	1.631	37.390	19.882	16.750	4.657	2.232	1.159	0.005	0.110
L-Carnitine	1.803	29093.141	4650.327	43870.026	13023.755	0.663	-0.593	0.007	0.110
Phenol	1.928	32.851	8.994	16.700	9.008	1.967	0.976	0.007	0.110
Saccharopine	1.670	116.490	33.781	180.919	57.808	0.644	-0.635	0.009	0.113
L-Lysine	1.770	143.052	17.861	109.517	25.911	1.306	0.385	0.011	0.123
L-Valine	1.532	8.497	0.785	11.060	3.005	0.768	-0.380	0.011	0.123
Phosphorylcholine	1.954	61.922	35.643	295.175	187.402	0.210	-2.253	0.015	0.133
N-Formyl-L-glutamic acid	1.396	19.137	8.337	28.971	9.873	0.661	-0.598	0.015	0.133
Hydroquinone	1.402	2.195	2.780	16.271	19.195	0.135	-2.890	0.019	0.144
D-Phenyllactic acid	1.575	54.805	9.273	42.794	9.416	1.281	0.357	0.019	0.144
Picolinic acid	1.626	1.214	0.798	0.387	0.199	3.135	1.649	0.019	0.144
3-(3,4-Dihydroxyphenyl)pyruvate	1.419	53.600	27.417	88.738	36.265	0.604	-0.727	0.019	0.144
6-Methylmercaptopurine	1.221	13.411	7.752	21.502	10.030	0.624	-0.681	0.019	0.144
Indolepyruvate	1.603	250.979	34.072	196.219	49.378	1.279	0.355	0.023	0.160
(9Z,12Z,15Z)-Octadecatrienoic acid	1.462	13.851	5.589	8.600	2.606	1.611	0.688	0.029	0.177
Taurocholic acid	1.448	14.097	6.361	25.826	13.733	0.546	-0.873	0.029	0.177
Phenylacetaldehyde	1.260	0.623	0.407	1.870	1.923	0.333	-1.586	0.029	0.177
Phosphoserine	1.497	1.802	0.353	2.287	0.464	0.788	-0.344	0.029	0.177
L-Pipecolic acid	1.374	31.391	4.547	26.433	4.784	1.188	0.248	0.037	0.191
12-OPDA	1.302	18.558	8.244	10.641	7.593	1.744	0.802	0.037	0.191
4-Oxoglutaramate	1.339	13.389	3.396	16.698	2.963	0.802	-0.319	0.037	0.191
N-Acetylmannosamine	1.563	10.370	8.299	68.612	68.589	0.151	-2.726	0.037	0.191
myo-Inositol	1.170	1.934	0.061	1.869	0.090	1.035	0.049	0.046	0.214
Oxoglutaric acid	1.303	55.553	21.493	79.213	26.429	0.701	-0.512	0.046	0.214
L-Asparagine	1.207	24.780	6.622	29.661	3.205	0.835	-0.259	0.046	0.214
N6-Acetyl-N6-hydroxy-L-lysine	1.452	89.255	76.677	219.627	148.288	0.406	-1.299	0.046	0.214
4-Hydroxycinnamic acid	1.296	21.548	25.492	0.000	0.000	616360.000	19.233	0.000	0.021
1-Naphthylamine	1.637	3.729	1.894	1.373	0.582	2.716	1.441	0.002	0.026
Jasmonic acid	1.837	28.240	12.335	62.290	21.772	0.453	-1.141	0.002	0.026
Prostaglandin F2a	1.433	17.921	18.415	0.000	0.000	512610.000	18.968	0.002	0.029
17a-Estradiol	1.213	12.568	12.666	2.761	0.397	4.553	2.187	0.003	0.033
D-Glucose	1.118	18.508	14.531	38.072	27.165	0.486	-1.041	0.003	0.033
Gentisic acid	1.652	0.963	0.368	0.451	0.230	2.135	1.094	0.004	0.039
Pseudouridine	1.684	911.789	208.934	636.262	71.940	1.433	0.519	0.005	0.044
beta-D-Fructose 6-phosphate	1.085	24.319	43.909	92.742	104.083	0.262	-1.931	0.005	0.044
Glyceric acid	1.775	0.272	0.141	0.076	0.015	3.586	1.842	0.009	0.056
N-Acetyl-alpha-D-glucosamine 1-phosphate	1.078	260.231	392.349	743.504	690.014	0.350	-1.514	0.009	0.056
3-(2-Hydroxyphenyl)propanoic acid	1.597	15.082	7.134	6.137	3.483	2.457	1.297	0.009	0.056
9,10-Epoxyoctadecenoic acid	1.604	1.778	0.363	1.190	0.401	1.494	0.579	0.011	0.067
N-Acetylglutamic acid	1.296	28.445	22.334	66.815	44.841	0.426	-1.232	0.011	0.067
Geranylgeranyl-PP	1.068	3.151	3.321	0.940	0.515	3.354	1.746	0.011	0.067
Anserine	1.400	47.288	51.046	102.548	32.895	0.461	-1.117	0.015	0.075
Formylanthranilic acid	1.455	2.154	0.388	1.302	0.866	1.655	0.727	0.015	0.075
Hydrogen phosphate	1.163	30.188	35.148	84.285	73.523	0.358	-1.481	0.019	0.085
13S-hydroxyoctadecadienoic acid	1.215	1.043	0.968	0.289	0.108	3.615	1.854	0.019	0.085
Phenylacetic acid	1.310	60.185	18.284	42.860	9.749	1.404	0.490	0.019	0.085
Salicylic acid	1.028	0.941	0.362	0.676	0.245	1.393	0.478	0.023	0.098
14,15-DiHETrE	1.344	1.478	1.064	0.494	0.355	2.993	1.582	0.037	0.128
Ascorbate	1.284	257.262	192.596	723.711	594.923	0.355	-1.492	0.046	0.146
Uric acid	1.070	2341.616	1158.079	29692.895	46866.866	0.079	-3.664	0.046	0.146
Hepoxilin B3	1.110	22.037	24.760	4.750	3.800	4.640	2.214	0.046	0.146

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值

	VIP	mean_Z	sd_Z	mean_X	sd_X	Fold Change_Z/X	log2(FC_Z/X)	p.value	FDR
(R) 2,3-Dihydroxy-3-methylvalerate	1.426	1.240	1.098	0.164	0.035	7.577	2.922	0.000	0.025
13-L-Hydroperoxylinoleic acid	1.417	8.208	7.859	0.573	0.362	14.325	3.841	0.000	0.025
Pipecolic acid	2.129	89.123	20.632	182.099	40.342	0.489	-1.031	0.001	0.025
1-Pyrroline-2-carboxylic acid	1.840	3.597	1.084	1.835	0.452	1.961	0.971	0.001	0.025
L-Isoleucine	1.956	56.360	3.968	74.172	10.558	0.760	-0.396	0.001	0.025
Phenylacetaldehyde	1.940	0.623	0.407	2.851	1.389	0.218	-2.195	0.001	0.025
Aminoadipic acid	2.158	19.942	4.004	9.367	2.193	2.129	1.090	0.001	0.027
cis-Aconitic acid	1.550	15.103	3.361	23.655	7.825	0.638	-0.647	0.002	0.032
N-Acetylmannosamine	1.587	10.370	8.299	78.791	66.394	0.132	-2.926	0.002	0.032
3-Dehydroshikimate	1.901	2.574	1.164	0.579	0.395	4.446	2.152	0.003	0.037
Cytosine	1.834	1236.314	131.404	1514.938	145.479	0.816	-0.293	0.004	0.040
L-Threonine	1.767	29.801	5.202	19.870	5.428	1.500	0.585	0.004	0.040
Sphinganine	1.496	5.089	1.515	11.256	6.414	0.452	-1.145	0.005	0.046
L-Lysine	1.627	143.052	17.861	108.598	25.236	1.317	0.398	0.007	0.052
S-Glutathionyl-L-cysteine	1.676	1476.059	267.309	2182.629	551.980	0.676	-0.564	0.009	0.059
Phosphoserine	1.620	1.802	0.353	5.439	3.419	0.331	-1.594	0.009	0.059
Antibiotic JI-20A	1.608	569.549	340.305	155.510	92.215	3.662	1.873	0.011	0.067
Serotonin	1.606	116.932	18.763	150.611	24.360	0.776	-0.365	0.011	0.067
Selenomethionine	1.214	0.364	0.140	1.677	1.891	0.217	-2.206	0.015	0.075
2-Oxoarginine	1.017	2.136	2.462	0.574	0.369	3.721	1.896	0.015	0.075
Phenylpyruvic acid	1.181	21.644	20.994	5.445	4.670	3.975	1.991	0.015	0.075
L-Leucine	1.529	12.504	1.127	14.433	1.548	0.866	-0.207	0.019	0.088
Piperidine	1.569	12.452	1.048	14.389	1.526	0.865	-0.209	0.019	0.088
N-Acetylneuraminate	1.347	62.986	12.662	77.324	10.867	0.815	-0.296	0.019	0.088
4-Hydroxycinnamoylagmatine	1.171	11691.117	11083.650	21889.918	8990.368	0.534	-0.905	0.019	0.088
6-Methylmercaptopurine	1.324	13.411	7.752	22.347	7.410	0.600	-0.737	0.019	0.088
Ureidopropionic acid	1.264	6.557	5.537	1.914	1.050	3.426	1.777	0.019	0.088
2-Dehydropantoate	1.482	242.779	28.501	290.148	40.441	0.837	-0.257	0.023	0.101
Ethylmethylacetic acid	1.228	0.228	0.195	1.352	1.585	0.169	-2.568	0.023	0.101
L-Valine	1.388	8.497	0.785	9.773	1.252	0.869	-0.202	0.029	0.115
L-Glutamine	1.180	23.882	2.749	26.977	3.438	0.885	-0.176	0.029	0.115
L-Pipecolic acid	1.290	31.391	4.547	26.418	4.170	1.188	0.249	0.037	0.131
2-Hydroxybutyric acid	1.100	8.583	0.838	9.364	0.858	0.917	-0.126	0.037	0.131
3-Methylindole	1.311	119.311	16.597	139.714	18.815	0.854	-0.228	0.037	0.131
Indoleacetaldehyde	1.287	285.247	51.062	336.476	36.700	0.848	-0.238	0.037	0.131
Succinic acid semialdehyde	1.485	1.030	0.570	3.121	2.183	0.330	-1.599	0.037	0.131
N-Formyl-L-glutamic acid	1.125	19.137	8.337	27.276	8.872	0.702	-0.511	0.037	0.131
O-Phosphoethanolamine	1.186	2.571	0.496	1.998	0.642	1.287	0.364	0.046	0.148
5,6-Dihydro-5-fluorouracil	1.362	110.712	6.618	122.085	11.908	0.907	-0.141	0.046	0.148
gamma-Glutamylalanine	1.181	7.796	3.127	12.807	6.621	0.609	-0.716	0.046	0.148
Taurocholic acid	1.252	14.097	6.361	40.244	35.579	0.350	-1.513	0.046	0.148
1-Naphthylamine	1.749	3.729	1.894	1.065	0.442	3.503	1.809	0.000	0.012
Stachyose	1.806	397.939	183.517	1948.217	1178.516	0.204	-2.292	0.000	0.012
Phenylethylamine	1.987	1.099	0.711	4.636	2.030	0.237	-2.077	0.001	0.019
Prostaglandin F2a	1.419	17.921	18.415	0.000	0.000	512610.000	18.968	0.002	0.027
17a-Estradiol	1.211	12.568	12.666	2.638	0.869	4.764	2.252	0.002	0.027
N-Acetylglutamic acid	1.525	28.445	22.334	103.714	74.408	0.274	-1.866	0.002	0.027
Uracil	1.337	5.908	5.542	15.567	10.521	0.380	-1.398	0.003	0.031
beta-D-Fructose 6-phosphate	1.076	24.319	43.909	61.132	36.850	0.398	-1.330	0.005	0.041
N-Acetyl-alpha-D-glucosamine 1-phosphate	1.151	260.231	392.349	637.450	377.525	0.408	-1.292	0.005	0.041
Geranylgeranyl-PP	1.104	3.151	3.321	0.821	0.516	3.840	1.941	0.009	0.054
Lipoxin A4	1.046	52.802	24.637	26.328	36.688	2.006	1.004	0.009	0.054
Threonic acid	1.496	522.805	339.086	1857.866	1384.724	0.281	-1.829	0.015	0.070
Dehydroascorbate	1.139	110.008	102.487	223.087	133.923	0.493	-1.020	0.015	0.070
N-Formyl-L-methionine	1.260	5881.408	4339.168	2275.458	640.922	2.585	1.370	0.015	0.070
pantothenic acid	1.432	12.874	8.547	30.971	18.405	0.416	-1.266	0.019	0.082
Fumaric acid	1.258	31.088	26.684	64.195	34.143	0.484	-1.046	0.019	0.082
5-Hydroxyindoleacetic acid	1.255	827.933	471.259	1597.465	920.120	0.518	-0.948	0.019	0.082
5-Aminopentanoic acid	1.248	1.219	0.484	0.686	0.500	1.776	0.829	0.023	0.095
Prostaglandin B2	1.341	0.291	0.376	1.399	1.333	0.208	-2.264	0.023	0.095
Hydrogen phosphate	1.159	30.188	35.148	69.315	44.906	0.436	-1.199	0.029	0.109
N-Acetylmuramate	1.274	4.616	6.204	12.953	8.849	0.356	-1.489	0.029	0.109
Fructose 1,6-bisphosphate	1.053	9.437	7.354	16.577	9.089	0.569	-0.813	0.037	0.123
D-Glucose	1.236	18.508	14.531	41.871	28.569	0.442	-1.178	0.046	0.141
Shikimic acid	1.129	13.136	17.685	38.074	34.085	0.345	-1.535	0.046	0.141
Ribose 1-phosphate	1.253	7.783	5.688	29.769	29.784	0.261	-1.935	0.046	0.141
Prostaglandin A2	1.176	4.188	3.232	1.623	1.224	2.581	1.368	0.046	0.141

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值

	VIP	mean_Z	sd_Z	mean_L	sd_L	Fold Change_Z/L	log2(FC_Z/L)	p.value	FDR
Methyl jasmonate	1.317	4.161	4.176	0.000	0.000	68381.000	16.061	0.000	0.006
Cytosine	1.661	1236.314	131.404	1537.623	159.157	0.804	-0.315	0.000	0.006
Antibiotic JI-20A	1.608	569.549	340.305	87.688	31.606	6.495	2.699	0.000	0.006
Indole	1.255	3.156	2.711	132.292	147.731	0.024	-5.389	0.000	0.006
L-Arginine	1.864	10.596	3.227	171.484	83.462	0.062	-4.016	0.000	0.006
Pipecolic acid	1.913	89.123	20.632	153.341	21.286	0.581	-0.783	0.000	0.007
Phosphoserine	1.812	1.802	0.353	2.930	0.515	0.615	-0.701	0.001	0.008
L-Methionine	1.726	281.652	65.072	157.245	40.188	1.791	0.841	0.001	0.008
Aminoadipic acid	1.921	19.942	4.004	9.523	2.396	2.094	1.066	0.001	0.008
Acetylcholine	1.413	172.195	31.573	133.878	14.449	1.286	0.363	0.001	0.011
3-(3,4-Dihydroxyphenyl)pyruvate	1.454	53.600	27.417	19.456	10.725	2.755	1.462	0.001	0.011
6-Methylmercaptopurine	1.508	13.411	7.752	2.941	3.430	4.561	2.189	0.001	0.011
Niacinamide	1.694	46.163	5.891	61.525	8.209	0.750	-0.414	0.002	0.013
Pyridoxamine	1.502	1.825	0.362	1.248	0.311	1.462	0.548	0.002	0.016
D-Phenyllactic acid	1.580	54.805	9.273	36.869	9.925	1.486	0.572	0.003	0.018
Picolinic acid	1.268	1.214	0.798	5.395	4.635	0.225	-2.152	0.003	0.018
N-Formyl-L-glutamic acid	1.471	19.137	8.337	6.581	6.821	2.908	1.540	0.003	0.018
L-Lysine	1.669	143.052	17.861	86.098	34.706	1.661	0.732	0.004	0.021
Pyroglutamic acid	1.563	13.691	6.515	28.260	9.313	0.484	-1.046	0.004	0.021
(R) 2,3-Dihydroxy-3-methylvalerate	1.107	1.240	1.098	0.359	0.280	3.452	1.787	0.004	0.021
Indolepyruvate	1.577	250.979	34.072	181.798	40.278	1.381	0.465	0.005	0.025
Phenol	1.471	32.851	8.994	20.073	6.177	1.636	0.711	0.005	0.025
Maleic acid homopolymer	1.539	115.632	19.331	252.181	109.926	0.459	-1.125	0.005	0.025
Acetaminophen	1.448	87.058	15.006	124.537	30.306	0.699	-0.517	0.006	0.029
Xanthine	1.382	155.811	33.220	115.830	17.827	1.345	0.428	0.008	0.034
1,1-Dimethylbiguanide	1.483	67.288	14.761	38.551	19.726	1.745	0.804	0.008	0.034
N-Acetylneuraminate	1.419	62.986	12.662	42.722	13.665	1.474	0.560	0.010	0.041
Cadaverine	1.311	84.519	10.664	71.467	8.230	1.183	0.242	0.010	0.041
Succinic acid semialdehyde	1.174	1.030	0.570	1.850	0.834	0.557	-0.844	0.010	0.041
L-Pipecolic acid	1.411	31.391	4.547	22.612	6.847	1.388	0.473	0.013	0.048
Pimelic acid	1.213	0.654	0.239	1.088	0.457	0.601	-0.735	0.013	0.048
Acetylphosphate	1.061	20.220	22.295	3.642	2.856	5.552	2.473	0.013	0.048
1-Hexadecanol	1.150	1.079	0.520	1.653	0.494	0.653	-0.615	0.013	0.048
13-L-Hydroperoxylinoleic acid	1.150	8.208	7.859	1.719	0.908	4.775	2.256	0.013	0.048
Leucodopachrome	1.391	8.200	4.179	14.217	3.863	0.577	-0.794	0.013	0.048
L-Glutamine	1.351	23.882	2.749	27.427	2.161	0.871	-0.200	0.016	0.057
Homovanillic acid	1.173	1.298	0.715	2.108	0.679	0.616	-0.699	0.016	0.057
Phosphonoacetate	1.264	2.199	1.969	0.348	0.168	6.316	2.659	0.016	0.057
Ureidopropionic acid	1.078	6.557	5.537	2.096	2.236	3.129	1.646	0.020	0.065
Porphobilinogen	1.110	1.251	1.524	3.293	2.247	0.380	-1.396	0.020	0.065
2-Hydroxycinnamic acid	1.018	272.553	61.604	220.360	44.578	1.237	0.307	0.030	0.089
2-Hydroxybutyric acid	1.132	8.583	0.838	7.652	0.849	1.122	0.166	0.030	0.089
L-Threonine	1.349	29.801	5.202	19.846	8.596	1.502	0.587	0.030	0.089
4-Hydroxycinnamoylagmatine	1.111	11691.117	11083.650	33280.282	26762.967	0.351	-1.509	0.030	0.089
2-Phenylacetamide	1.282	185.328	27.836	135.258	46.992	1.370	0.454	0.037	0.104
beta-Alanine	1.131	151.157	26.247	126.086	17.967	1.199	0.262	0.037	0.104
Cortexolone	1.177	2494.375	1449.308	5318.621	3183.926	0.469	-1.092	0.037	0.104
Mannitol	1.279	5.067	3.485	38.707	37.231	0.131	-2.933	0.037	0.104
(9Z,12Z,15Z)-Octadecatrienoic acid	1.140	13.851	5.589	8.223	4.370	1.684	0.752	0.045	0.117
N-Formyl-L-methionine	1.423	5881.408	4339.168	354.332	328.257	16.599	4.053	0.000	0.004
Pyruvic acid	1.757	10.807	3.087	3.143	2.027	3.438	1.782	0.000	0.004
5-Aminopentanoic acid	1.657	1.219	0.484	10.774	5.697	0.113	-3.144	0.000	0.004
1-Naphthylamine	1.530	3.729	1.894	0.893	0.402	4.175	2.062	0.000	0.004
Ribose 1-phosphate	1.502	7.783	5.688	89.285	60.897	0.087	-3.520	0.000	0.004
2-Keto-6-acetamidocaproate	1.883	0.536	0.157	2.245	0.626	0.239	-2.065	0.000	0.004
Fructose 1,6-bisphosphate	1.373	9.437	7.354	0.648	0.558	14.561	3.864	0.000	0.004
Lipoxin A4	1.700	52.802	24.637	4.771	5.729	11.068	3.468	0.000	0.004
D-Glutamine	1.535	29.392	17.872	2.483	3.699	11.838	3.565	0.000	0.004
Gluconolactone	1.639	95.755	40.425	17.317	22.238	5.529	2.467	0.000	0.004
Taurine	1.701	3625.110	589.386	2272.058	419.876	1.595	0.674	0.001	0.004
L-Malic acid	1.420	45.212	41.185	361.999	261.713	0.125	-3.001	0.001	0.004
L-2-Hydroxyglutaric acid	1.501	47.184	28.085	5.925	8.677	7.964	2.993	0.001	0.006
Shikimic acid	1.431	13.136	17.685	327.905	259.332	0.040	-4.642	0.001	0.006
trans-Cinnamate	1.727	1.494	0.825	4.150	1.107	0.360	-1.474	0.001	0.006
alpha-Ketoisovaleric acid	1.543	16.198	1.993	7.683	5.661	2.108	1.076	0.001	0.007
Glyceric acid	1.432	0.272	0.141	3.054	2.288	0.089	-3.487	0.002	0.009
Stachyose	1.650	397.939	183.517	71.147	34.913	5.593	2.484	0.002	0.009
Gentisic acid	1.351	0.963	0.368	0.466	0.234	2.067	1.048	0.002	0.011
4-Hydroxycinnamic acid	1.015	21.548	25.492	1.993	3.201	10.811	3.434	0.002	0.011
Geranylgeranyl-PP	1.282	3.151	3.321	81.962	78.497	0.038	-4.701	0.003	0.013
Dehydroepiandrosterone	1.236	4.426	2.962	16.918	12.806	0.262	-1.935	0.004	0.015
Uric acid	1.322	2341.616	1158.079	1023.624	238.582	2.288	1.194	0.005	0.018
beta-D-Fructose 6-phosphate	1.019	24.319	43.909	68.765	40.319	0.354	-1.500	0.005	0.018
13S-hydroxyoctadecadienoic acid	1.401	1.043	0.968	2.574	0.818	0.405	-1.302	0.005	0.018
15-Deoxy-d-12,14-PGJ2	1.458	207.224	48.366	330.253	83.498	0.627	-0.672	0.005	0.018
Prostaglandin A2	1.484	4.188	3.232	18.803	10.715	0.223	-2.167	0.005	0.018
12-Keto-tetrahydro-leukotriene B4	1.439	0.250	0.266	1.539	1.015	0.162	-2.623	0.006	0.021
19(S)-HETE	1.327	3.458	1.024	2.073	0.726	1.669	0.739	0.008	0.025
D-Octopine	1.274	3.503	0.845	2.244	0.897	1.561	0.642	0.008	0.025
Uridine	1.263	19794.703	13983.743	4917.887	3259.308	4.025	2.009	0.008	0.025
Phospho-anandamide	1.454	11.641	12.152	50.188	28.078	0.232	-2.108	0.008	0.025
Sphingosine 1-phosphate	1.344	31.067	33.159	118.339	72.418	0.263	-1.929	0.013	0.036
N-Acetylaspartylglutamate	1.235	33.273	14.053	14.702	12.796	2.263	1.178	0.013	0.036
Prostaglandin B2	1.079	0.291	0.376	0.894	0.663	0.326	-1.619	0.016	0.042
Alpha-D-Glucose	1.234	5.217	1.614	3.264	1.160	1.598	0.677	0.016	0.042
Mesaconate	1.146	1.876	0.417	5.420	4.162	0.346	-1.530	0.030	0.068
2-Aminophenol	1.115	65.453	25.061	32.393	30.667	2.021	1.015	0.037	0.080

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值

	VIP	mean_Z	sd_Z	mean_H	sd_H	Fold Change_Z/H	log2(FC_Z/H)	p.value	FDR
Phosphorylcholine	1.512	61.922	35.643	0.000	0.000	1017500.000	19.957	0.000	0.002
Methyl jasmonate	1.131	4.161	4.176	0.000	0.000	68381.000	16.061	0.000	0.002
Choline	1.589	23.648	11.839	0.000	0.000	388600.000	18.568	0.000	0.002
Glycocholic acid	1.442	60.210	38.859	0.000	0.000	989410.000	19.916	0.000	0.002
Dodecanoic acid	1.561	0.580	0.306	0.000	0.000	9528.500	13.218	0.000	0.002
Mannitol	1.401	5.067	3.485	0.000	0.000	83263.000	16.345	0.000	0.002
2-Hydroxy-3-oxoadipate	1.495	7.895	4.681	0.000	0.000	129740.000	16.985	0.000	0.002
7-Dehydrodesmosterol	1.473	10.711	6.580	0.000	0.000	176010.000	17.425	0.000	0.002
Cytosine	1.424	1236.314	131.404	1670.620	272.126	0.740	-0.434	0.000	0.002
Pipecolic acid	1.828	89.123	20.632	198.162	18.100	0.450	-1.153	0.000	0.002
L-Lysine	1.835	143.052	17.861	56.378	10.625	2.537	1.343	0.000	0.002
L-Methionine	1.596	281.652	65.072	126.870	42.564	2.220	1.151	0.000	0.002
Pimelic acid	1.717	0.654	0.239	3.203	0.975	0.204	-2.292	0.000	0.002
L-Threonine	1.678	29.801	5.202	16.246	2.186	1.834	0.875	0.000	0.002
1-Aminocyclopropanecarboxylic acid	1.734	61.105	6.943	39.893	3.065	1.532	0.615	0.000	0.002
Pyroglutamic acid	1.816	13.691	6.515	41.957	3.683	0.326	-1.616	0.000	0.002
Indolepyruvate	1.662	250.979	34.072	150.961	27.619	1.663	0.733	0.000	0.002
Aminoadipic acid	1.740	19.942	4.004	7.465	1.804	2.671	1.417	0.000	0.002
(R) 2,3-Dihydroxy-3-methylvalerate	1.156	1.240	1.098	0.108	0.013	11.492	3.523	0.000	0.002
1,1-Dimethylbiguanide	1.623	67.288	14.761	30.167	9.681	2.231	1.157	0.000	0.002
L-Arginine	1.831	10.596	3.227	377.357	94.222	0.028	-5.154	0.000	0.002
N-Formyl-L-glutamic acid	1.387	19.137	8.337	6.035	4.133	3.171	1.665	0.000	0.002
Phosphoserine	1.795	1.802	0.353	8.670	2.055	0.208	-2.266	0.000	0.002
2-Phenylacetamide	1.564	185.328	27.836	124.011	17.102	1.494	0.580	0.000	0.003
L-Pipecolic acid	1.708	31.391	4.547	17.468	2.921	1.797	0.846	0.000	0.003
D-Phenyllactic acid	1.631	54.805	9.273	31.482	5.670	1.741	0.800	0.000	0.003
Antibiotic JI-20A	1.340	569.549	340.305	112.799	49.067	5.049	2.336	0.001	0.003
cis-Aconitic acid	1.232	15.103	3.361	32.621	15.861	0.463	-1.111	0.001	0.004
3-(3,4-Dihydroxyphenyl)pyruvate	1.331	53.600	27.417	17.012	5.388	3.151	1.656	0.001	0.005
N-Acetylmannosamine	1.533	10.370	8.299	76.427	37.912	0.136	-2.882	0.001	0.005
Indole	1.199	3.156	2.711	19.615	15.713	0.161	-2.636	0.001	0.006
Phenylacetaldehyde	1.143	0.623	0.407	4.413	3.948	0.141	-2.825	0.001	0.006
p-Octopamine	1.435	155.694	42.252	84.511	20.574	1.842	0.881	0.001	0.006
L-Proline	1.014	24.140	16.816	9.577	3.350	2.521	1.334	0.002	0.007
Pyridoxamine	1.385	1.825	0.362	2.633	0.466	0.693	-0.529	0.002	0.007
6-Methylmercaptopurine	1.191	13.411	7.752	4.502	2.980	2.979	1.575	0.002	0.007
Indole-3-acetaldehyde oxime	1.187	37.390	19.882	15.539	4.559	2.406	1.267	0.002	0.007
Dopamine	1.235	34.440	20.999	84.627	40.669	0.407	-1.297	0.002	0.007
2-Hydroxycinnamic acid	1.313	272.553	61.604	175.909	46.320	1.549	0.632	0.003	0.010
Acetylcholine	1.324	172.195	31.573	123.899	20.791	1.390	0.475	0.003	0.010
Succinic acid semialdehyde	1.413	1.030	0.570	2.946	1.232	0.350	-1.516	0.003	0.010
Sphinganine	1.382	5.089	1.515	8.525	2.017	0.597	-0.744	0.003	0.010
Ureidopropionic acid	1.065	6.557	5.537	1.372	1.392	4.779	2.257	0.003	0.010
3-Dehydroshikimate	1.479	2.574	1.164	0.658	0.072	3.911	1.967	0.004	0.012
Xanthine	1.228	155.811	33.220	114.103	16.512	1.365	0.449	0.005	0.015
Serotonin	1.348	116.932	18.763	153.047	20.358	0.764	-0.388	0.005	0.015
13-L-Hydroperoxylinoleic acid	1.065	8.208	7.859	1.016	0.700	8.081	3.014	0.005	0.015
2-Keto-glutaramic acid	1.311	55.830	12.990	24.259	22.339	2.301	1.203	0.005	0.015
1-Pyrroline-2-carboxylic acid	1.138	3.597	1.084	2.121	1.048	1.696	0.762	0.010	0.027
2-Dehydropantoate	1.182	242.779	28.501	204.449	23.196	1.188	0.248	0.013	0.033
Phenol	1.167	32.851	8.994	20.218	8.537	1.625	0.700	0.013	0.033
beta-Alanine	1.113	151.157	26.247	117.185	24.410	1.290	0.367	0.016	0.039
Stearidonic acid	1.051	1.228	0.691	2.705	1.589	0.454	-1.139	0.016	0.039
6-Keto-prostaglandin F1alpha	1.127	4.628	1.259	2.753	1.497	1.681	0.750	0.016	0.039
L-Isoleucine	1.034	56.360	3.968	63.389	7.420	0.889	-0.170	0.020	0.047
4-Pyridoxic acid	1.027	4.528	4.266	0.726	1.090	6.240	2.641	0.020	0.047
D-Xylose	1.179	17.957	5.905	8.737	6.728	2.055	1.039	0.020	0.047
N6-Acetyl-L-lysine	1.041	6.516	1.095	5.339	0.808	1.220	0.287	0.025	0.055
Saccharopine	1.037	116.490	33.781	152.506	24.669	0.764	-0.389	0.030	0.065
Creatine	1.022	397.443	69.102	319.505	62.118	1.244	0.315	0.045	0.087
N-Formyl-L-methionine	1.471	5881.408	4339.168	473.535	222.305	12.420	3.635	0.000	0.005
1-Naphthylamine	1.530	3.729	1.894	1.122	0.464	3.324	1.733	0.000	0.005
D-Glutamine	1.618	29.392	17.872	2.408	1.648	12.203	3.609	0.000	0.005
Gluconolactone	1.721	95.755	40.425	19.694	17.407	4.862	2.282	0.000	0.005
2-Keto-6-acetamidocaproate	1.946	0.536	0.157	1.389	0.299	0.386	-1.373	0.000	0.005
Fructose 1,6-bisphosphate	1.398	9.437	7.354	1.048	0.354	9.003	3.170	0.000	0.005
alpha-Ketoisovaleric acid	1.753	16.198	1.993	5.998	5.515	2.700	1.433	0.000	0.006
Lipoxin A4	1.689	52.802	24.637	8.791	10.325	6.006	2.587	0.000	0.006
Prostaglandin B2	1.212	0.291	0.376	33.169	38.185	0.009	-6.832	0.001	0.006
15-Deoxy-d-12,14-PGJ2	1.691	207.224	48.366	327.260	56.672	0.633	-0.659	0.001	0.006
12-Keto-tetrahydro-leukotriene B4	1.589	0.250	0.266	1.226	0.658	0.204	-2.294	0.001	0.009
Taurine	1.551	3625.110	589.386	2539.353	555.721	1.428	0.514	0.002	0.011
Pyruvic acid	1.659	10.807	3.087	4.604	2.526	2.347	1.231	0.002	0.011
Salicylic acid	1.148	0.941	0.362	0.621	0.119	1.516	0.600	0.002	0.011
Ribose 1-phosphate	1.495	7.783	5.688	46.078	31.087	0.169	-2.566	0.002	0.011
5-Aminopentanoic acid	1.439	1.219	0.484	0.576	0.248	2.117	1.082	0.002	0.013
Formylanthranilic acid	1.494	2.154	0.388	1.022	0.842	2.108	1.076	0.003	0.015
17a-Estradiol	1.012	12.568	12.666	3.471	0.897	3.621	1.856	0.004	0.018
19(S)-HETE	1.415	3.458	1.024	5.906	1.949	0.586	-0.772	0.004	0.018
N-Acetyl-D-glucosamine	1.492	3.416	0.771	5.169	1.204	0.661	-0.598	0.005	0.021
L-2-Hydroxyglutaric acid	1.399	47.184	28.085	12.976	11.136	3.636	1.862	0.005	0.021
L-Malic acid	1.371	45.212	41.185	142.493	82.682	0.317	-1.656	0.005	0.021
3-(2-Hydroxyphenyl)propanoic acid	1.206	15.082	7.134	6.069	7.336	2.485	1.313	0.013	0.043
Threonic acid	1.002	522.805	339.086	1537.224	1476.915	0.340	-1.556	0.020	0.060
D-Octopine	1.016	3.503	0.845	2.815	0.470	1.244	0.315	0.020	0.060
Phenylacetic acid	1.229	60.185	18.284	42.081	6.939	1.430	0.516	0.020	0.060
Kynurenic acid	1.280	10.085	3.752	3.945	5.240	2.556	1.354	0.020	0.060
Shikimic acid	1.153	13.136	17.685	98.610	104.832	0.133	-2.908	0.020	0.060
Uridine	1.018	19794.703	13983.743	8226.846	8299.218	2.406	1.267	0.025	0.069
Oxoadipic acid	1.018	55.736	17.974	81.108	32.067	0.687	-0.541	0.030	0.079

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值

	VIP	mean_Z	sd_Z	mean_A	sd_A	Fold Change_Z/A	log2(FC_Z/A)	p.value	FDR
Phosphorylcholine	1.696	61.922	35.643	0.000	0.000	1017500.000	19.957	0.000	0.006
Methyl jasmonate	1.257	4.161	4.176	0.000	0.000	68381.000	16.061	0.000	0.006
Choline	1.785	23.648	11.839	0.000	0.000	388600.000	18.568	0.000	0.006
Dodecanoic acid	1.753	0.580	0.306	0.000	0.000	9528.500	13.218	0.000	0.006
Ciliatine	1.032	0.576	0.759	0.000	0.000	9467.900	13.209	0.000	0.006
2-Hydroxy-3-oxoadipate	1.675	7.895	4.681	0.000	0.000	129740.000	16.985	0.000	0.006
7-Dehydrodesmosterol	1.650	10.711	6.580	0.000	0.000	176010.000	17.425	0.000	0.006
L-Isoleucine	1.899	56.360	3.968	74.490	7.002	0.757	-0.402	0.000	0.006
Pipecolic acid	1.969	89.123	20.632	240.467	54.096	0.371	-1.432	0.000	0.006
Antibiotic JI-20A	1.472	569.549	340.305	130.094	19.608	4.378	2.130	0.000	0.006
L-Threonine	1.654	29.801	5.202	20.236	3.028	1.473	0.558	0.000	0.006
Vanillylmandelic acid	2.018	2.660	0.611	6.528	1.110	0.407	-1.296	0.000	0.006
L-Arginine	1.204	10.596	3.227	144.141	161.878	0.074	-3.766	0.000	0.006
Phosphoserine	1.893	1.802	0.353	5.759	1.796	0.313	-1.676	0.000	0.006
Aminoadipic acid	1.867	19.942	4.004	9.435	2.439	2.114	1.080	0.001	0.009
Cytosine	1.719	1236.314	131.404	1754.458	290.464	0.705	-0.505	0.001	0.010
Pimelic acid	1.603	0.654	0.239	1.811	0.816	0.361	-1.470	0.001	0.010
Indole	1.416	3.156	2.711	166.643	153.812	0.019	-5.722	0.001	0.010
Sphinganine	1.752	5.089	1.515	9.789	2.229	0.520	-0.944	0.002	0.012
13-L-Hydroperoxylinoleic acid	1.215	8.208	7.859	0.745	0.600	11.020	3.462	0.002	0.015
N6-Acetyl-N6-hydroxy-L-lysine	1.673	89.255	76.677	302.183	114.311	0.295	-1.759	0.002	0.015
Niacinamide	1.469	46.163	5.891	58.493	8.580	0.789	-0.342	0.003	0.018
Glycocholic acid	1.337	60.210	38.859	9.843	27.839	6.117	2.613	0.004	0.022
Piperidine	1.503	12.452	1.048	14.296	1.008	0.871	-0.199	0.005	0.027
3-Dehydroshikimate	1.615	2.574	1.164	0.748	0.205	3.440	1.782	0.005	0.027
Succinic acid semialdehyde	1.607	1.030	0.570	2.728	1.076	0.378	-1.405	0.005	0.027
(R) 2,3-Dihydroxy-3-methylvalerate	1.093	1.240	1.098	0.320	0.266	3.869	1.952	0.005	0.027
Taurocholic acid	1.390	14.097	6.361	31.988	15.805	0.441	-1.182	0.005	0.027
L-Leucine	1.476	12.504	1.127	14.224	0.796	0.879	-0.186	0.007	0.032
Acetylcholine	1.302	172.195	31.573	134.715	18.824	1.278	0.354	0.007	0.032
(9Z,12Z,15Z)-Octadecatrienoic acid	1.283	13.851	5.589	7.854	1.918	1.764	0.818	0.007	0.032
N6-Acetyl-L-lysine	1.375	6.516	1.095	9.105	2.239	0.716	-0.483	0.007	0.032
Phenylpyruvic acid	1.080	21.644	20.994	4.397	4.683	4.922	2.299	0.007	0.032
4-Guanidinobutanoic acid	1.310	6.190	1.956	11.416	5.127	0.542	-0.883	0.009	0.036
Serotonin	1.414	116.932	18.763	164.975	40.013	0.709	-0.497	0.011	0.043
Phosphonoacetate	1.197	2.199	1.969	0.349	0.360	6.305	2.656	0.011	0.043
L-Methionine	1.288	281.652	65.072	204.785	40.759	1.375	0.460	0.015	0.051
4-Hydroxycinnamoylagmatine	1.060	11691.117	11083.650	30509.495	24049.389	0.383	-1.384	0.015	0.051
Ureidopropionic acid	1.148	6.557	5.537	1.651	1.002	3.973	1.990	0.015	0.051
N-Acetylmannosamine	1.522	10.370	8.299	41.565	23.979	0.249	-2.003	0.015	0.051
D-Phenyllactic acid	1.245	54.805	9.273	42.708	9.193	1.283	0.360	0.019	0.062
N2-Succinyl-L-ornithine	1.201	55.343	18.637	89.139	35.292	0.621	-0.688	0.019	0.062
Betaine	1.108	104.487	14.850	132.867	34.711	0.786	-0.347	0.023	0.073
Indolepyruvate	1.224	250.979	34.072	207.407	34.180	1.210	0.275	0.023	0.073
L-Serine	1.199	5.507	4.939	13.719	8.299	0.401	-1.317	0.023	0.073
Picolinic acid	1.239	1.214	0.798	4.217	3.375	0.288	-1.797	0.029	0.086
N-Acetylserotonin	1.115	360.055	130.154	621.451	320.114	0.579	-0.787	0.029	0.086
cis-Aconitic acid	1.098	15.103	3.361	21.749	8.322	0.694	-0.526	0.029	0.086
Linoleic acid	1.021	12.470	6.104	7.462	3.092	1.671	0.741	0.029	0.086
N-Acetylneuraminate	1.142	62.986	12.662	101.355	48.005	0.621	-0.686	0.037	0.100
Stearidonic acid	1.126	1.228	0.691	2.228	1.076	0.551	-0.860	0.037	0.100
Glycerophosphocholine	1.098	565.225	113.238	755.102	227.865	0.749	-0.418	0.046	0.118
1-Naphthylamine	1.568	3.729	1.894	1.177	0.446	3.168	1.664	0.001	0.012
Threonic acid	1.529	522.805	339.086	4691.387	3731.652	0.111	-3.166	0.001	0.014
Prostaglandin B2	1.302	0.291	0.376	7.304	8.157	0.040	-4.649	0.001	0.014
Lipoxin A4	1.737	52.802	24.637	9.848	10.615	5.362	2.423	0.001	0.014
N-Formyl-L-methionine	1.398	5881.408	4339.168	1088.177	936.357	5.405	2.434	0.002	0.018
beta-D-Fructose 6-phosphate	1.277	24.319	43.909	124.988	109.835	0.195	-2.362	0.002	0.021
12-Keto-leukotriene B4	1.098	1152.135	1302.852	145.216	119.092	7.934	2.988	0.002	0.021
Hydrogen phosphate	1.313	30.188	35.148	107.322	79.281	0.281	-1.830	0.003	0.024
Ribose 1-phosphate	1.456	7.783	5.688	97.017	87.144	0.080	-3.640	0.003	0.024
L-2-Hydroxyglutaric acid	1.459	47.184	28.085	13.474	8.232	3.502	1.808	0.004	0.028
D-Octopine	1.602	3.503	0.845	2.179	0.525	1.607	0.685	0.005	0.032
L-Malic acid	1.277	45.212	41.185	274.694	270.868	0.165	-2.603	0.005	0.032
4-Hydroxycinnamic acid	1.059	21.548	25.492	2.640	3.666	8.162	3.029	0.005	0.032
Alpha-D-Glucose	1.487	5.217	1.614	3.070	0.872	1.699	0.765	0.007	0.037
5-Aminopentanoic acid	1.255	1.219	0.484	4.608	4.126	0.264	-1.919	0.009	0.043
Malonate	1.182	3.835	7.598	12.575	7.868	0.305	-1.713	0.009	0.043
N-Acetyl-alpha-D-glucosamine 1-phosphate	1.199	260.231	392.349	944.620	778.008	0.275	-1.860	0.011	0.051
12-Keto-tetrahydro-leukotriene B4	1.476	0.250	0.266	4.225	3.790	0.059	-4.080	0.011	0.051
trans-Cinnamate	1.333	1.494	0.825	3.760	2.373	0.397	-1.332	0.011	0.051
17a-Estradiol	1.022	12.568	12.666	3.598	1.593	3.493	1.804	0.015	0.059
Uracil	1.087	5.908	5.542	17.270	15.722	0.342	-1.548	0.015	0.059
15-Deoxy-d-12,14-PGJ2	1.405	207.224	48.366	144.205	35.591	1.437	0.523	0.015	0.059
Oxoadipic acid	1.447	55.736	17.974	79.712	12.126	0.699	-0.516	0.015	0.059
9,10-Epoxyoctadecenoic acid	1.271	1.778	0.363	1.311	0.386	1.357	0.440	0.019	0.069
(R)-3-Hydroxybutyric acid	1.238	12.665	10.051	81.058	84.918	0.156	-2.678	0.019	0.069
Glyceric acid	1.130	0.272	0.141	1.506	1.741	0.181	-2.467	0.019	0.069
19(S)-HETE	1.217	3.458	1.024	2.317	0.891	1.492	0.578	0.023	0.080
N-Acetylmuramate	1.298	4.616	6.204	24.472	22.141	0.189	-2.406	0.023	0.080
Formylanthranilic acid	1.212	2.154	0.388	3.506	1.688	0.614	-0.703	0.023	0.080
Pyruvic acid	1.229	10.807	3.087	6.886	3.514	1.570	0.650	0.029	0.091
Glucosamine 6-phosphate	1.315	76.567	34.721	37.393	21.680	2.048	1.034	0.029	0.091
3-(2-Hydroxyphenyl)propanoic acid	1.307	15.082	7.134	7.068	4.558	2.134	1.093	0.029	0.091
L-Glutamic acid	1.231	10.223	7.147	28.530	21.633	0.358	-1.481	0.037	0.105
Uric acid	1.008	2341.616	1158.079	1502.908	409.877	1.558	0.640	0.037	0.105
Dehydroepiandrosterone	1.233	4.426	2.962	8.270	3.485	0.535	-0.902	0.037	0.105
Adenine	1.240	36.393	13.306	55.014	17.727	0.662	-0.596	0.037	0.105
Traumatic Acid	1.240	1.703	1.220	4.865	3.698	0.350	-1.514	0.037	0.105
D-Glutamine	1.112	29.392	17.872	13.938	9.476	2.109	1.076	0.046	0.122

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值

	VIP	p.value	FDR
(R) 2,3-Dihydroxy-3-methylvalerate	1.669	0.000	0.019
Phosphonoacetate	1.877	0.000	0.019
L-Glutamine	2.799	0.000	0.019
Aminoadipic acid	1.038	0.001	0.021
13-L-Hydroperoxylinoleic acid	1.511	0.001	0.021
5-Methylcytosine	2.693	0.001	0.023
Pipecolic acid	1.019	0.001	0.023
Phenylacetaldehyde	1.319	0.001	0.025
Phenol	2.386	0.003	0.031
1H-Indole-3-acetamide	1.800	0.004	0.034
Choline	1.084	0.004	0.035
cis-Aconitic acid	1.034	0.004	0.035
L-Threonine	1.190	0.005	0.037
gamma-Glutamylalanine	1.908	0.005	0.039
N-Acetylmannosamine	1.574	0.006	0.041
L-Lysine	1.941	0.007	0.045
Hydroquinone	1.691	0.012	0.062
Antibiotic JI-20A	1.586	0.013	0.064
L-Valine	1.897	0.014	0.065
Indole-3-acetaldehyde oxime	1.800	0.014	0.066
6-Methylmercaptopurine	1.429	0.017	0.071
L-Asparagine	1.087	0.017	0.071
1-Aminocyclopropanecarboxylic acid	2.071	0.019	0.077
S-Glutathionyl-L-cysteine	1.364	0.020	0.081
Saccharopine	1.965	0.021	0.082
12-OPDA	1.263	0.022	0.084
N-Formyl-L-glutamic acid	1.597	0.023	0.085
L-Carnitine	1.978	0.033	0.105
Serotonin	1.067	0.034	0.108
3-(3,4-Dihydroxyphenyl)pyruvate	1.704	0.037	0.113
L-Pipecolic acid	1.593	0.041	0.120
D-Phenyllactic acid	1.805	0.041	0.121
Indolepyruvate	1.919	0.048	0.132
L-Leucine	1.036	0.049	0.133
Prostaglandin F2a	1.702	0.000	0.008
1-Naphthylamine	1.846	0.000	0.009
Hippuric acid	1.090	0.000	0.010
17a-Estradiol	1.460	0.001	0.016
4-Hydroxycinnamic acid	1.350	0.002	0.018
beta-D-Fructose 6-phosphate	1.270	0.003	0.024
N-Acetyl-alpha-D-glucosamine 1-phosphate	1.221	0.004	0.029
Pseudouridine	1.910	0.007	0.039
Geranylgeranyl-PP	1.288	0.008	0.040
D-Glucose	1.066	0.008	0.042
Gentisic acid	1.162	0.013	0.055
Glyceric acid	1.688	0.013	0.055
3-(2-Hydroxyphenyl)propanoic acid	1.330	0.018	0.068
Hydrogen phosphate	1.286	0.023	0.081
Formylanthranilic acid	1.626	0.030	0.094
N-Formyl-L-methionine	1.222	0.037	0.107
9,10-Epoxyoctadecenoic acid	1.455	0.037	0.107
Resveratrol	1.122	0.039	0.110
Phenylacetic acid	1.473	0.043	0.118

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值

	VIP	p.value	FDR
Methyl jasmonate	1.413	0.000	0.003
6-Methylmercaptopurine	1.095	0.000	0.003
N-Formyl-L-glutamic acid	1.126	0.000	0.003
Picolinic acid	1.353	0.000	0.003
L-Arginine	2.026	0.000	0.003
Indole	1.408	0.000	0.004
L-Glutamine	1.061	0.000	0.004
Aminoadipic acid	2.073	0.000	0.004
Phosphoserine	1.980	0.001	0.006
L-Methionine	1.887	0.001	0.006
Antibiotic JI-20A	1.841	0.001	0.006
Pipecolic acid	1.514	0.001	0.007
Cytosine	1.035	0.001	0.007
(R) 2,3-Dihydroxy-3-methylvalerate	1.280	0.001	0.008
Acetaminophen	1.369	0.001	0.008
Homovanillic acid	1.093	0.001	0.009
Acetylcholine	1.534	0.002	0.012
Niacinamide	1.812	0.002	0.012
7-Dehydrodesmosterol	1.111	0.003	0.015
Maleic acid homopolymer	1.547	0.003	0.015
L-Lysine	1.822	0.003	0.016
D-Phenyllactic acid	1.696	0.003	0.016
Phenol	1.392	0.004	0.017
Cadaverine	1.418	0.004	0.018
Pyroglutamic acid	1.543	0.004	0.020
beta-Alanine	1.079	0.004	0.020
1-Hexadecanol	1.120	0.006	0.026
Indolepyruvate	1.572	0.008	0.031
N-Acetylneuraminate	1.248	0.009	0.033
Succinic acid semialdehyde	1.343	0.011	0.037
1,1-Dimethylbiguanide	1.533	0.012	0.039
L-Pipecolic acid	1.540	0.013	0.041
gamma-Glutamylalanine	1.032	0.013	0.042
1-Aminocyclopropanecarboxylic acid	1.106	0.017	0.050
Porphobilinogen	1.194	0.018	0.053
Xanthine	1.383	0.018	0.054
Pimelic acid	1.367	0.021	0.059
L-Threonine	1.527	0.025	0.065
13-L-Hydroperoxylinoleic acid	1.324	0.030	0.075
Leucodopachrome	1.549	0.030	0.076
2-Hydroxybutyric acid	1.231	0.031	0.077
Cortexolone	1.202	0.039	0.092
(9Z,12Z,15Z)-Octadecatrienoic acid	1.274	0.043	0.098
4-Hydroxycinnamic acid	1.162	0.000	0.001
Pyruvic acid	1.407	0.000	0.002
Glyceric acid	1.543	0.000	0.002
N-Formyl-L-methionine	1.640	0.000	0.002
Lipoxin A4	1.756	0.000	0.002
1-Naphthylamine	1.734	0.000	0.002
5-Aminopentanoic acid	1.764	0.000	0.002
Gluconolactone	1.311	0.000	0.002
Geranylgeranyl-PP	1.416	0.000	0.002
2-Keto-6-acetamidocaproate	1.994	0.000	0.002
13S-hydroxyoctadecadienoic acid	1.313	0.000	0.002
L-Malic acid	1.543	0.000	0.002
Taurine	1.828	0.000	0.003
Dehydroepiandrosterone	1.314	0.000	0.003
17a-Estradiol	1.005	0.000	0.003
D-Glutamine	1.342	0.000	0.003
Ribose 1-phosphate	1.649	0.001	0.004
L-2-Hydroxyglutaric acid	1.651	0.001	0.005
Phospho-anandamide	1.507	0.001	0.005
Gentisic acid	1.436	0.002	0.007
Prostaglandin A2	1.549	0.002	0.008
Shikimic acid	1.477	0.002	0.008
15-Deoxy-d-12,14-PGJ2	1.360	0.004	0.013
alpha-Ketoisovaleric acid	1.431	0.004	0.013
Sphingosine 1-phosphate	1.414	0.005	0.014
D-Octopine	1.459	0.008	0.021
12-Keto-tetrahydro-leukotriene B4	1.598	0.008	0.021
Hydrogen phosphate	1.027	0.009	0.023
19(S)-HETE	1.463	0.014	0.031
Uridine	1.333	0.017	0.036
9,10-Epoxyoctadecenoic acid	1.038	0.026	0.050
Salicylic acid	1.025	0.028	0.054
12-Keto-leukotriene B4	1.111	0.029	0.055
2-Aminophenol	1.207	0.039	0.069
Prostaglandin B2	1.149	0.040	0.070

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值

	VIP	p.value	FDR
(R) 2,3-Dihydroxy-3-methylvalerate	1.356	0.000	0.001
1-Aminocyclopropanecarboxylic acid	1.985	0.000	0.001
N-Formyl-L-glutamic acid	1.030	0.000	0.001
L-Lysine	2.041	0.000	0.001
Phosphoserine	1.938	0.000	0.001
Pimelic acid	1.875	0.000	0.001
L-Threonine	1.872	0.000	0.001
Aminoadipic acid	1.892	0.000	0.001
Methyl jasmonate	1.217	0.000	0.001
7-Dehydrodesmosterol	1.313	0.000	0.001
Glycocholic acid	1.318	0.000	0.001
Porphobilinogen	1.099	0.000	0.001
L-Pipecolic acid	1.880	0.000	0.001
Pyroglutamic acid	1.796	0.000	0.001
L-Arginine	1.941	0.000	0.001
1,1-Dimethylbiguanide	1.667	0.000	0.001
D-Phenyllactic acid	1.785	0.000	0.002
L-Methionine	1.760	0.000	0.002
Indolepyruvate	1.749	0.000	0.002
Pipecolic acid	1.727	0.000	0.002
Cytosine	1.105	0.000	0.003
p-Octopamine	1.248	0.001	0.003
cis-Aconitic acid	1.403	0.001	0.003
2-Phenylacetamide	1.628	0.001	0.003
3-Dehydroshikimate	1.602	0.001	0.003
Stearidonic acid	1.091	0.001	0.005
Antibiotic JI-20A	1.537	0.001	0.005
Sphinganine	1.406	0.001	0.006
Indole-3-acetaldehyde oxime	1.344	0.002	0.006
L-Proline	1.034	0.002	0.006
Phenylacetaldehyde	1.260	0.002	0.007
beta-Alanine	1.086	0.002	0.007
Succinic acid semialdehyde	1.583	0.003	0.010
Acetylcholine	1.456	0.003	0.010
2-Hydroxycinnamic acid	1.409	0.003	0.010
N-Acetylmannosamine	1.260	0.004	0.011
Creatine	1.033	0.004	0.013
Dopamine	1.298	0.005	0.015
Indole	1.335	0.005	0.015
Phenol	1.136	0.006	0.017
13-L-Hydroperoxylinoleic acid	1.235	0.007	0.020
2-Dehydropantoate	1.038	0.011	0.027
4,5-Dihydroorotic acid	1.056	0.012	0.028
gamma-Glutamylalanine	1.204	0.012	0.029
Xanthine	1.237	0.013	0.031
Serotonin	1.119	0.015	0.035
Pyridoxamine	1.253	0.017	0.039
Taurocholic acid	1.083	0.018	0.039
D-Xylose	1.292	0.027	0.056
L-Isoleucine	1.035	0.031	0.062
Ethylmethylacetic acid	1.018	0.037	0.071
Homovanillic acid	1.010	0.040	0.076
N6-Acetyl-L-lysine	1.106	0.044	0.081
6-Keto-prostaglandin F1alpha	1.012	0.045	0.082
D-Fructose	1.016	0.047	0.084
N-Formyl-L-methionine	1.652	0.000	0.003
Gluconolactone	1.323	0.000	0.003
Pyruvic acid	1.264	0.000	0.003
1-Naphthylamine	1.673	0.000	0.003
Prostaglandin B2	1.325	0.000	0.004
D-Glutamine	1.375	0.000	0.004
Lipoxin A4	1.698	0.000	0.004
2-Keto-6-acetamidocaproate	1.937	0.000	0.005
19(S)-HETE	1.359	0.001	0.006
15-Deoxy-d-12,14-PGJ2	1.467	0.001	0.007
17a-Estradiol	1.137	0.001	0.007
alpha-Ketoisovaleric acid	1.622	0.002	0.009
Taurine	1.637	0.002	0.009
12-Keto-tetrahydro-leukotriene B4	1.696	0.002	0.009
L-Malic acid	1.404	0.002	0.011
Prostaglandin F2a	1.059	0.003	0.015
Formylanthranilic acid	1.446	0.004	0.018
Salicylic acid	1.183	0.005	0.018
Ribose 1-phosphate	1.390	0.006	0.023
L-2-Hydroxyglutaric acid	1.487	0.007	0.024
3-(2-Hydroxyphenyl)propanoic acid	1.310	0.008	0.027
N-Acetyl-D-glucosamine	1.421	0.012	0.035
5-Aminopentanoic acid	1.387	0.013	0.036
Phenylacetic acid	1.302	0.019	0.049
Oxoadipic acid	1.068	0.026	0.062
D-Octopine	1.110	0.033	0.074

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值

	VIP	p.value	FDR
Phosphoserine	2.087	0.000	0.005
Dodecanoic acid	1.068	0.000	0.005
Methyl jasmonate	1.357	0.000	0.005
7-Dehydrodesmosterol	1.445	0.000	0.005
Vanillylmandelic acid	2.075	0.000	0.005
L-Isoleucine	2.051	0.000	0.005
L-Threonine	1.834	0.000	0.006
Aminoadipic acid	2.021	0.000	0.006
Pipecolic acid	2.014	0.001	0.006
L-Arginine	1.357	0.001	0.007
Sphinganine	1.770	0.001	0.007
Pimelic acid	1.812	0.001	0.008
3-Dehydroshikimate	1.748	0.001	0.009
Picolinic acid	1.274	0.001	0.009
Indole	1.564	0.001	0.010
(R) 2,3-Dihydroxy-3-methylvalerate	1.295	0.001	0.010
Cytosine	1.371	0.001	0.010
Antibiotic JI-20A	1.699	0.002	0.014
N6-Acetyl-L-lysine	1.386	0.003	0.015
13-L-Hydroperoxylinoleic acid	1.429	0.003	0.015
Glycocholic acid	1.226	0.003	0.017
N6-Acetyl-N6-hydroxy-L-lysine	1.663	0.005	0.021
Stearidonic acid	1.096	0.006	0.024
L-Serine	1.213	0.006	0.025
Taurocholic acid	1.420	0.007	0.028
Succinic acid semialdehyde	1.799	0.007	0.029
Niacinamide	1.567	0.008	0.030
(9Z,12Z,15Z)-Octadecatrienoic acid	1.446	0.010	0.036
Acetylcholine	1.424	0.011	0.038
N2-Succinyl-L-ornithine	1.218	0.015	0.046
D-Phenyllactic acid	1.286	0.017	0.052
Piperidine	1.462	0.018	0.053
L-Leucine	1.352	0.019	0.055
5,6-Dihydro-5-fluorouracil	1.104	0.022	0.061
Indolepyruvate	1.119	0.022	0.062
L-Methionine	1.385	0.024	0.064
4-Guanidinobutanoic acid	1.176	0.026	0.068
L-Lysine	1.193	0.026	0.068
Serotonin	1.356	0.031	0.077
Linoleic acid	1.126	0.031	0.077
4-Hydroxycinnamoylagmatine	1.053	0.035	0.082
Betaine	1.264	0.037	0.086
cis-Aconitic acid	1.230	0.040	0.091
N-Acetylserotonin	1.268	0.046	0.100
4-Hydroxycinnamic acid	1.239	0.000	0.003
1-Naphthylamine	1.775	0.000	0.006
Glyceric acid	1.219	0.000	0.006
Lipoxin A4	1.778	0.001	0.008
Prostaglandin B2	1.447	0.001	0.008
beta-D-Fructose 6-phosphate	1.240	0.001	0.010
N-Formyl-L-methionine	1.617	0.002	0.011
Threonic acid	1.703	0.002	0.012
Geranylgeranyl-PP	1.020	0.002	0.014
Dehydroepiandrosterone	1.119	0.003	0.014
D-Octopine	1.821	0.003	0.015
17a-Estradiol	1.205	0.003	0.015
L-Malic acid	1.393	0.003	0.016
Hydrogen phosphate	1.297	0.003	0.016
5-Aminopentanoic acid	1.352	0.004	0.017
Formylanthranilic acid	1.059	0.004	0.017
Malonate	1.333	0.004	0.018
Oxoadipic acid	1.434	0.005	0.020
Ribose 1-phosphate	1.622	0.005	0.021
Traumatic Acid	1.297	0.006	0.024
N-Acetyl-alpha-D-glucosamine 1-phosphate	1.199	0.008	0.027
Alpha-D-Glucose	1.026	0.008	0.027
12-Keto-leukotriene B4	1.276	0.011	0.033
L-2-Hydroxyglutaric acid	1.590	0.012	0.036
9,10-Epoxyoctadecenoic acid	1.256	0.013	0.037
3-(2-Hydroxyphenyl)propanoic acid	1.434	0.014	0.040
12-Keto-tetrahydro-leukotriene B4	1.631	0.015	0.042
Glucosamine 6-phosphate	1.253	0.028	0.066
(R)-3-Hydroxybutyric acid	1.361	0.038	0.081
19(S)-HETE	1.345	0.041	0.085
15-Deoxy-d-12,14-PGJ2	1.116	0.041	0.086

注：*_VIP：VIP值；mean_*：平均值；sd_*：标准差；fold change：倍性变化；log2(FC)：倍性变化的log2值；pvalue：统计学p值；FDR：pvalue校正值