差异代谢物筛选
通过对代谢物进行筛选,寻找差异代谢物(biomarker)。相关差异代谢物筛选条件有:
  1. p-value ≤ 0.05 且 VIP ≥ 1[1]
  2. p-value ≤ 0.05 且 fold_change ≥ 1.5或≤0.667[2]
  3. one-way ANOVA p-value ≤ 0.05[3]
  4. two-way ANOVA p-value ≤ 0.05[4]
详细含义:
筛选值 筛选值含义 筛选阈值 备注
p-value Student's t test p-value ≤ 0.05 统计学上显著差异
VIP OPLS-DA第一主成分变量重要性值投影 VIP ≥ 1
Fold change 两两组别间倍性变化 fold_change ≥1.5或≤0.667 含量差异较大
one-way ANOVA p-value 一维方差分析 p-value ≤ 0.05 主要用于时间序列,梯度浓度处理等
two-way ANOVA p-value 两因素方差分析 p-value ≤ 0.05 一般为两因素情况,如对照-处理+时间序列样本
本实验采用条件 1 进行代谢物筛选,最终获得的差异代谢物见下表:

差异信息汇总信息
差异信息汇总表格;dam_DEG.xlsx (正离子模式)
dam_DEG.xlsx 包含“stats”和“ALL_DEG.xlsx”两个工作簿,其中“stats”统计了各个比对组别差异代谢物的上、下调情况,“ALL_DEG”汇总了所有比对组别的差异代谢物信息。

DOWNLOAD
mz rt rtmin CTRL vs DM_VIP mean_CTRL sd_CTRL mean_DM sd_DM Fold Change log2(FC) p.value FDR
M520T451 519.962 450.549 7.510 2.385 825866.196 97535.762 561492.722 88811.216 0.680 -0.557 0.000 0.000
M890T407 890.438 407.010 6.780 2.324 415717.160 76225.517 233156.902 62716.110 0.561 -0.834 0.000 0.001
M643T429_2 643.386 429.450 7.160 2.321 337609.540 85257.667 152595.859 53868.221 0.452 -1.146 0.000 0.001
M575T468 575.011 467.815 7.800 2.273 2144785.632 582700.253 981659.406 336320.364 0.458 -1.127 0.000 0.001
M660T482_2 660.073 482.385 8.040 2.272 412546.014 90427.356 208157.392 75097.725 0.505 -0.987 0.000 0.001
M552T458 551.632 457.911 7.630 2.270 403098.659 93414.970 203626.153 67551.504 0.505 -0.985 0.000 0.001
M107T90 107.049 89.944 1.500 2.221 568938.707 272195.513 123159.238 45881.249 0.216 -2.208 0.000 0.001
M926T474 925.515 474.352 7.910 2.220 210052.890 46210.474 110381.214 39500.208 0.525 -0.928 0.000 0.001
M99T599 99.080 599.231 9.990 2.201 6401665.381 698317.488 4716843.845 776472.109 0.737 -0.441 0.000 0.002
M854T400 853.515 400.043 6.670 2.180 233497.320 39746.128 140079.916 43864.663 0.600 -0.737 0.000 0.002
M620T874_1 619.715 873.513 14.560 2.113 682719.250 158097.429 385095.395 128289.549 0.564 -0.826 0.000 0.005
M273T70 272.794 69.552 1.160 2.092 323691.624 79352.325 156114.449 85284.967 0.482 -1.052 0.000 0.006
M127T145 127.111 145.139 2.420 2.090 1538049.535 604319.277 3340604.909 1087172.310 2.172 1.119 0.000 0.006
M169T659 169.122 658.948 10.980 2.072 240780.904 62833.264 398548.209 91763.098 1.655 0.727 0.000 0.007
M493T446 492.634 446.471 7.440 2.065 1442038.822 298944.114 867790.711 281922.580 0.602 -0.733 0.000 0.007
M589T876 588.712 875.560 14.590 2.053 989946.315 166214.013 597947.351 227705.984 0.604 -0.727 0.000 0.007
M402T406_2 402.265 405.533 6.760 2.051 263661.576 71220.354 141076.700 54005.415 0.535 -0.902 0.000 0.007
M520T450 520.296 450.462 7.510 2.049 584496.635 119282.023 380303.842 89502.916 0.651 -0.620 0.000 0.007
M169T25 169.122 25.218 0.420 2.037 447280.856 92213.263 714192.531 170811.408 1.597 0.675 0.000 0.008
M223T51 223.063 51.312 0.860 2.031 405770.265 107321.462 646702.986 140930.706 1.594 0.672 0.000 0.008
M553T461_2 553.322 461.019 7.680 2.012 1034326.314 257734.916 617124.173 183330.899 0.597 -0.745 0.000 0.009
M171T5 171.149 5.488 0.090 2.011 275899.067 50710.419 396211.156 74374.597 1.436 0.522 0.000 0.009
M99T227 99.080 226.703 3.780 2.008 18765102.185 4089951.575 13158496.847 1353704.727 0.701 -0.512 0.000 0.009
M103T5 103.075 5.433 0.090 1.995 1132659.391 338421.901 647108.061 164716.678 0.571 -0.808 0.000 0.010
M897T876 896.562 875.587 14.590 1.990 485989.265 141375.173 271829.125 87470.508 0.559 -0.838 0.000 0.010
M271T51 271.263 50.511 0.840 1.990 509046.032 137039.418 878428.760 245687.679 1.726 0.787 0.000 0.010
M566T461_2 565.974 461.291 7.690 1.984 820941.590 206927.805 535771.232 85606.126 0.653 -0.616 0.000 0.010
M608T420_2 608.317 419.545 6.990 1.979 277904.451 89203.849 138994.113 62142.537 0.500 -1.000 0.000 0.011
M678T434_2 678.366 433.832 7.230 1.967 719755.016 129927.821 483748.184 132408.090 0.672 -0.573 0.000 0.011
M711T443_2 711.401 442.708 7.380 1.967 449975.655 132742.301 251412.252 84863.641 0.559 -0.840 0.000 0.011
M187T884_1 186.571 884.192 14.740 1.958 3069942.060 850185.793 1894520.611 410552.755 0.617 -0.696 0.000 0.011
M837T878 837.007 878.288 14.640 1.958 957618.242 128804.536 701374.508 156324.407 0.732 -0.449 0.000 0.011
M199T746 199.169 745.854 12.430 1.957 2075846.756 533239.500 3771197.870 1215968.572 1.817 0.861 0.000 0.011
M392T383 391.750 383.113 6.390 1.957 234072.588 41509.364 148823.227 53028.184 0.636 -0.653 0.000 0.011
M488T447 487.628 446.853 7.450 1.957 685320.643 195122.531 382211.440 143397.882 0.558 -0.842 0.000 0.011
M487T447_2 487.293 446.777 7.450 1.953 3065440.956 1454227.260 1199961.012 416335.990 0.391 -1.353 0.000 0.011
M806T750 806.309 750.192 12.500 1.952 161833.918 28580.489 106287.095 33655.087 0.657 -0.607 0.000 0.011
M920T874_4 920.080 873.703 14.560 1.952 1018446.356 280235.436 569181.515 225765.427 0.559 -0.839 0.000 0.011
M837T462 837.463 461.562 7.690 1.948 632946.459 91786.690 433808.177 129115.650 0.685 -0.545 0.000 0.011
M239T256 239.088 255.652 4.260 1.930 12206262.740 2177236.109 9219962.744 1147393.684 0.755 -0.405 0.000 0.012
M516T454 516.309 454.407 7.570 1.928 3933829.703 1099200.688 2337683.373 718728.343 0.594 -0.751 0.000 0.012
M217T514 217.107 513.975 8.570 1.927 21362126.729 4026549.747 14801626.398 3557856.756 0.693 -0.529 0.000 0.012
M664T871 663.741 870.983 14.520 1.925 499727.703 166166.317 268263.639 94917.228 0.537 -0.897 0.000 0.012
M305T353 305.158 353.308 5.890 1.925 306113.551 82502.036 183469.210 58372.954 0.599 -0.739 0.000 0.012
M623T474_2 623.024 473.816 7.900 1.923 267905.668 75722.380 158097.951 49977.038 0.590 -0.761 0.000 0.012
M674T434_1 673.912 433.862 7.230 1.922 637143.874 152241.666 410597.946 108765.615 0.644 -0.634 0.000 0.012
M917T474 917.026 473.709 7.900 1.916 439399.815 81366.300 286552.582 95877.518 0.652 -0.617 0.000 0.013
M610T474_1 610.037 473.512 7.890 1.908 712908.887 206920.120 396563.649 164407.056 0.556 -0.846 0.000 0.014
M531T458_1 530.985 457.790 7.630 1.902 3297393.366 1037511.067 1763494.963 766580.889 0.535 -0.903 0.000 0.014
M546T461_2 545.995 461.281 7.690 1.897 2338867.584 633821.848 1399039.491 478327.190 0.598 -0.741 0.000 0.014
M775T455 774.961 454.597 7.580 1.897 603251.393 196751.980 342583.616 101958.182 0.568 -0.816 0.000 0.014
M551T461 551.336 461.034 7.680 1.896 1655243.689 410041.863 1033725.991 327369.249 0.625 -0.679 0.000 0.014
M493T447_2 493.303 446.989 7.450 1.896 355262.454 85569.622 209247.796 87884.605 0.589 -0.764 0.000 0.014
M564T461_1 563.988 461.329 7.690 1.895 697791.738 151412.840 475965.558 110991.854 0.682 -0.552 0.000 0.014
M532T458_1 531.654 457.697 7.630 1.895 1060929.188 296145.676 612464.531 236706.205 0.577 -0.793 0.000 0.014
M575T467 575.345 467.432 7.790 1.894 1829616.169 504392.643 1110451.263 343312.987 0.607 -0.720 0.000 0.014
M722T446_2 722.423 446.288 7.440 1.892 909966.914 244635.533 535283.734 202005.624 0.588 -0.766 0.000 0.014
M827T750 827.260 750.319 12.510 1.890 1073327.088 265322.304 635868.018 258031.333 0.592 -0.755 0.000 0.014
M577T414 576.845 414.061 6.900 1.886 424154.898 159463.992 207480.088 95123.440 0.489 -1.032 0.000 0.014
M744T450_2 744.435 450.310 7.510 1.882 719510.276 280676.222 357474.953 136794.603 0.497 -1.009 0.000 0.014
M577T468_1 576.662 467.624 7.790 1.880 754380.587 272008.779 388745.340 158825.916 0.515 -0.956 0.000 0.014
M549T458 549.312 457.743 7.630 1.880 706794.828 108914.666 514422.005 122248.131 0.728 -0.458 0.000 0.014
M548T461_1 547.646 460.737 7.680 1.880 981787.414 331612.731 506705.175 237953.402 0.516 -0.954 0.000 0.014
M239T342 239.088 341.654 5.690 1.879 6877753.662 1626526.176 10086180.530 2186232.987 1.466 0.552 0.000 0.014
M731T447_1 730.936 446.989 7.450 1.877 930539.273 256165.596 574990.510 168381.089 0.618 -0.695 0.000 0.014
M497T450_1 496.628 450.407 7.510 1.876 1379480.998 423504.288 779347.002 297359.544 0.565 -0.824 0.000 0.014
M515T451_2 514.637 450.514 7.510 1.874 10431329.174 1497831.227 7837685.581 1639993.585 0.751 -0.412 0.000 0.014
M517T455_1 516.644 454.510 7.580 1.873 3070766.559 1134308.696 1653709.681 487344.269 0.539 -0.893 0.000 0.014
M662T482_1 661.725 481.988 8.030 1.871 594635.339 145266.984 379651.159 115770.210 0.638 -0.647 0.000 0.014
M831T400 831.442 400.026 6.670 1.863 214210.632 56084.597 128123.606 49524.050 0.598 -0.741 0.000 0.015
M496T446 495.937 445.975 7.430 1.860 459368.192 131844.715 263545.888 108650.082 0.574 -0.802 0.000 0.015
M410T392_1 409.710 391.901 6.530 1.859 1403583.950 281401.087 950370.545 276513.020 0.677 -0.563 0.000 0.015
M656T429_1 655.852 429.366 7.160 1.859 2048613.157 430915.916 1455368.593 291371.268 0.710 -0.493 0.000 0.015
M552T461_1 551.670 461.075 7.680 1.859 1189054.816 298281.271 753904.930 236176.646 0.634 -0.657 0.000 0.015
M614T476_2 614.030 476.455 7.940 1.854 372283.910 138520.545 189128.004 83262.942 0.508 -0.977 0.000 0.015
M126T477 125.986 476.571 7.940 1.853 2217113.294 464749.642 3421201.751 931357.584 1.543 0.626 0.000 0.015
M456T434_2 456.270 434.087 7.230 1.849 1121334.052 182745.817 801678.065 211867.591 0.715 -0.484 0.000 0.015
M617T478 616.610 477.776 7.960 1.849 175953.962 68825.759 89866.120 33485.920 0.511 -0.969 0.000 0.015
M337T845 337.329 844.969 14.080 1.848 169786.308 46922.061 102964.843 35851.241 0.606 -0.722 0.000 0.015
M127T51 127.111 50.904 0.850 1.847 1621397.886 811344.944 3345224.751 1266841.711 2.063 1.045 0.000 0.015
M623T425_2 623.349 424.916 7.080 1.846 343366.295 95139.432 201396.225 81623.668 0.587 -0.770 0.000 0.015
M516T450_1 515.640 450.269 7.500 1.842 665360.306 132220.738 480619.457 97322.999 0.722 -0.469 0.000 0.016
M559T461_4 559.332 461.034 7.680 1.841 2236112.729 394275.094 1614989.350 383201.314 0.722 -0.469 0.000 0.016
M500T447_1 499.609 446.729 7.450 1.841 262019.767 75426.216 155402.419 57488.158 0.593 -0.754 0.000 0.016
M601T471_2 601.372 470.743 7.850 1.840 1915845.605 378532.349 1321436.795 366012.957 0.690 -0.536 0.000 0.016
M568T464_1 567.662 464.005 7.730 1.835 1062023.900 257407.036 665430.204 241656.320 0.627 -0.674 0.000 0.016
M604T471_1 603.692 470.863 7.850 1.828 403805.345 120723.665 251475.330 66390.274 0.623 -0.683 0.000 0.017
M535T454_2 534.972 454.445 7.570 1.826 598922.933 93309.931 442506.995 104254.314 0.739 -0.437 0.000 0.017
M470T439 469.628 438.529 7.310 1.825 285889.872 87871.516 165926.958 63428.572 0.580 -0.785 0.000 0.017
M727T443 726.898 442.601 7.380 1.820 1605300.505 182421.247 1264354.010 245318.086 0.788 -0.344 0.000 0.018
M575T876_2 575.040 876.359 14.610 1.816 931226.741 249011.500 535087.523 257426.797 0.575 -0.799 0.000 0.018
M574T464_1 574.007 464.469 7.740 1.812 1826542.007 318821.772 1343284.953 302502.318 0.735 -0.443 0.000 0.019
M572T877 571.716 876.747 14.610 1.810 985776.118 379963.250 516203.090 205679.038 0.524 -0.933 0.000 0.019
M537T454_1 536.623 453.954 7.570 1.810 822395.536 138403.080 582663.805 167570.271 0.709 -0.497 0.000 0.019
M512T455 511.637 454.734 7.580 1.803 428301.457 150763.406 229015.181 105139.743 0.535 -0.903 0.000 0.020
M531T454_2 531.299 454.056 7.570 1.798 3398768.630 659117.862 2503228.622 501702.928 0.737 -0.441 0.001 0.020
M799T750 799.208 750.351 12.510 1.798 989228.283 227099.135 611409.248 261885.651 0.618 -0.694 0.001 0.020
M787T458 787.458 457.715 7.630 1.796 1104638.770 392238.820 615933.119 230054.828 0.558 -0.843 0.001 0.020
M494T446 494.286 446.397 7.440 1.792 1441026.745 379110.028 941777.878 268955.080 0.654 -0.614 0.001 0.021
M937T477_1 936.562 476.874 7.950 1.791 350805.264 63038.900 245281.778 74212.983 0.699 -0.516 0.001 0.021
M722T881_2 721.966 881.184 14.690 1.787 1045947.625 237504.933 705622.193 209946.025 0.675 -0.568 0.001 0.022
M127T4 127.111 4.242 0.070 1.786 1849414.484 561750.559 3158937.753 1065528.083 1.708 0.772 0.001 0.022
M739T750 739.209 750.205 12.500 1.785 3974599.771 939381.909 2410815.201 1106098.817 0.607 -0.721 0.001 0.022
M665T434_1 664.898 434.017 7.230 1.784 1249864.449 318376.830 802551.570 271105.409 0.642 -0.639 0.001 0.022
M676T485 676.065 484.718 8.080 1.783 247107.359 95865.391 131222.994 52382.731 0.531 -0.913 0.001 0.022
M661T482 661.390 482.121 8.040 1.774 473525.494 133684.066 303720.337 89439.145 0.641 -0.641 0.001 0.023
M187T67 187.057 67.093 1.120 1.774 1215551.098 930504.953 219685.714 208282.415 0.181 -2.468 0.001 0.023
M486T443_2 485.955 442.723 7.380 1.774 1339190.751 193209.686 1022042.028 226029.959 0.763 -0.390 0.001 0.023
M818T461 817.984 461.092 7.680 1.767 899417.755 238644.062 596267.124 162954.445 0.663 -0.593 0.001 0.024
M783T750 783.235 750.276 12.500 1.765 2156842.287 550180.015 1316919.305 574150.671 0.611 -0.712 0.001 0.024
M634T476_1 634.026 476.341 7.940 1.764 885334.529 251274.400 563865.059 176421.149 0.637 -0.651 0.001 0.024
M512T428 512.290 427.600 7.130 1.762 657976.236 142393.111 433808.759 157950.442 0.659 -0.601 0.001 0.025
M696T387 696.238 386.981 6.450 1.758 102215.766 37424.068 183257.391 66763.387 1.793 0.842 0.001 0.025
M611T353 611.312 353.390 5.890 1.755 267581.407 60157.385 174815.527 65016.453 0.653 -0.614 0.001 0.026
M576T414_2 576.344 414.072 6.900 1.753 1332532.860 414137.244 807112.030 292216.736 0.606 -0.723 0.001 0.026
M167T226 167.012 226.057 3.770 1.753 1731060.738 175353.605 2346172.680 553001.120 1.355 0.439 0.001 0.026
M838T879 837.508 878.625 14.640 1.752 896151.191 151790.880 660007.363 167584.859 0.736 -0.441 0.001 0.026
M595T414_1 594.820 414.073 6.900 1.747 726647.607 120018.451 547079.339 124351.671 0.753 -0.410 0.001 0.026
M599T473 599.021 473.428 7.890 1.747 1049423.352 328688.487 609576.825 270212.720 0.581 -0.784 0.001 0.026
M618T874_2 618.063 874.038 14.570 1.747 1383620.191 293876.266 1011852.530 209018.055 0.731 -0.451 0.001 0.026
M533T458_2 532.971 457.577 7.630 1.745 989606.489 268905.215 615430.122 242314.271 0.622 -0.685 0.001 0.026
M625T874_2 625.077 873.784 14.560 1.744 617937.231 203908.218 342738.102 171903.118 0.555 -0.850 0.001 0.026
M805T458_2 805.488 457.810 7.630 1.743 1109802.763 222160.214 833719.583 151417.865 0.751 -0.413 0.001 0.026
M744T450_1 743.935 450.321 7.510 1.743 1768244.397 499112.986 1099345.139 414990.022 0.622 -0.686 0.001 0.026
M568T461 567.626 461.257 7.690 1.742 446372.904 157999.697 263732.905 83662.029 0.591 -0.759 0.001 0.026
M614T874 613.726 873.520 14.560 1.742 1566000.582 355759.402 1046774.964 355129.562 0.668 -0.581 0.001 0.026
M379T383 379.184 383.499 6.390 1.740 280207.791 66500.407 179333.544 71525.830 0.640 -0.644 0.001 0.026
M598T420_1 597.855 419.531 6.990 1.740 4079947.863 1299218.310 2515567.319 809023.951 0.617 -0.698 0.001 0.026
M634T874 634.411 873.505 14.560 1.740 601961.438 182545.159 350881.390 162060.319 0.583 -0.779 0.001 0.026
M793T455_1 792.936 454.594 7.580 1.739 1135877.738 147903.604 921134.844 146949.609 0.811 -0.302 0.001 0.026
M614T476_1 613.696 476.341 7.940 1.738 699253.525 271515.721 392397.386 131876.514 0.561 -0.834 0.001 0.026
M682T387 682.239 387.174 6.450 1.737 157238.440 63898.951 327769.182 150592.568 2.084 1.060 0.001 0.026
M663T482_2 663.376 481.969 8.030 1.735 285701.231 105754.682 154063.368 74036.997 0.539 -0.891 0.001 0.026
M721T446 721.420 446.323 7.440 1.733 3431333.868 1220347.578 2016789.970 675470.686 0.588 -0.767 0.001 0.026
M722T868 722.108 868.498 14.470 1.732 306233.465 84641.203 197271.702 65410.419 0.644 -0.634 0.001 0.027
M437T434 437.257 434.272 7.240 1.730 772620.556 322224.619 417317.367 142515.492 0.540 -0.889 0.001 0.027
M545T458_1 544.657 457.669 7.630 1.728 2483735.301 528018.308 1767549.619 465232.425 0.712 -0.491 0.001 0.027
M590T414_2 590.313 414.026 6.900 1.728 366842.653 104210.854 230549.373 84561.408 0.628 -0.670 0.001 0.027
M502T447 502.282 446.658 7.440 1.727 1233214.192 271972.287 860971.580 244761.908 0.698 -0.518 0.001 0.027
M454T407_1 453.737 407.062 6.780 1.725 979998.062 268801.530 627080.501 221357.506 0.640 -0.644 0.001 0.027
M898T875_1 897.535 875.088 14.580 1.723 905125.144 268229.873 600469.235 141692.550 0.663 -0.592 0.001 0.027
M523T455_1 522.654 454.613 7.580 1.723 512884.650 145167.230 326698.166 113451.421 0.637 -0.651 0.001 0.027
M239T150 239.088 149.910 2.500 1.722 11571045.236 4243259.098 6260073.168 3114896.861 0.541 -0.886 0.001 0.027
M612T474_1 611.688 473.512 7.890 1.719 535452.628 167301.369 330004.218 117557.934 0.616 -0.698 0.001 0.028
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M949T527_1 948.508 527.208 8.790 1.147 1072493.326 352336.185 1450994.859 529279.570 1.353 0.436 0.040 0.127
M806T405 806.418 405.486 6.760 1.146 218206.304 62922.865 165276.569 63934.014 0.757 -0.401 0.040 0.128
M329T667 329.005 667.064 11.120 1.145 1202175.755 100846.377 1335597.588 199583.495 1.111 0.152 0.040 0.128
M254T252 254.196 252.477 4.210 1.145 270572.634 135038.553 376257.837 118563.492 1.391 0.476 0.040 0.128
M591T370 591.356 370.212 6.170 1.145 728184.895 228016.587 545008.342 211829.786 0.748 -0.418 0.040 0.128
M840T464 839.996 464.160 7.740 1.143 459190.610 173278.638 331594.360 132360.312 0.722 -0.470 0.041 0.129
M427T407_2 427.249 407.005 6.780 1.143 228502.615 55821.287 177610.545 65776.349 0.777 -0.363 0.041 0.129
M652T749 652.161 749.289 12.490 1.142 668902.474 135880.640 511434.867 227907.064 0.765 -0.387 0.041 0.129
M786T392 786.413 391.953 6.530 1.142 942653.475 177752.519 783095.782 204186.334 0.831 -0.268 0.041 0.129
M788T458_1 787.959 457.577 7.630 1.142 794948.446 274155.953 574135.930 257702.762 0.722 -0.469 0.041 0.129
M616T874 616.077 874.458 14.570 1.140 2512504.571 476076.378 2058297.826 605947.960 0.819 -0.288 0.041 0.130
M621T474_2 621.002 473.748 7.900 1.140 348559.422 114268.305 260554.504 98065.093 0.748 -0.420 0.041 0.130
M567T408 567.297 408.394 6.810 1.139 1313459.310 354767.980 1043945.930 295331.621 0.795 -0.331 0.041 0.130
M598T365 597.766 365.309 6.090 1.139 88524.682 56464.236 191816.277 164123.688 2.167 1.116 0.041 0.130
M600T420 600.333 419.534 6.990 1.139 1251842.411 509542.795 892598.318 349125.366 0.713 -0.488 0.041 0.130
M513T450 513.320 450.407 7.510 1.139 2969014.772 587627.414 2459072.761 640364.916 0.828 -0.272 0.041 0.130
M568T414_2 568.332 414.074 6.900 1.138 293248.946 124379.269 209968.867 72164.045 0.716 -0.482 0.042 0.131
M722T442_1 721.890 442.249 7.370 1.137 1699760.239 523858.309 1362608.337 257269.382 0.802 -0.319 0.042 0.131
M639T477_2 639.351 476.714 7.950 1.137 317506.753 109677.892 233375.521 93840.867 0.735 -0.444 0.042 0.131
M634T477 633.692 476.550 7.940 1.137 823188.735 251423.784 637053.343 197783.285 0.774 -0.370 0.042 0.131
M434T321 434.285 320.960 5.350 1.136 130689.365 49118.908 97475.500 29688.380 0.746 -0.423 0.042 0.131
M450T421 450.243 420.875 7.010 1.136 296393.625 130004.480 203658.535 92924.999 0.687 -0.541 0.042 0.131
M605T874_1 604.706 874.396 14.570 1.136 1068768.494 238974.634 841308.429 305135.120 0.787 -0.345 0.042 0.131
M761T750 761.253 750.177 12.500 1.135 416761.350 130858.168 297193.944 156693.565 0.713 -0.488 0.042 0.131
M350T288 350.186 287.539 4.790 1.135 490890.937 279976.107 319633.278 102342.497 0.651 -0.619 0.042 0.131
M188T191 188.068 191.237 3.190 1.135 3025417.821 1074179.734 2252792.978 788304.241 0.745 -0.425 0.042 0.131
M345T61 344.865 60.697 1.010 1.135 295851.952 48351.568 254717.084 51214.091 0.861 -0.216 0.042 0.131
M735T750 735.258 750.183 12.500 1.135 2059365.966 611017.168 1533321.910 661278.792 0.745 -0.426 0.042 0.131
M785T880 784.995 879.696 14.660 1.134 3477929.691 642581.063 2862930.620 830575.014 0.823 -0.281 0.042 0.132
M474T438_2 474.249 438.216 7.300 1.134 835206.227 176735.638 681421.788 195299.528 0.816 -0.294 0.042 0.132
M99T654 99.080 654.106 10.900 1.133 4695729.140 790627.258 5397723.084 905335.375 1.149 0.201 0.042 0.132
M672T883 672.451 883.049 14.720 1.133 916355.315 184367.706 728679.564 261823.157 0.795 -0.331 0.043 0.132
M133T51 133.085 51.032 0.850 1.133 14281677.180 3559201.812 11457331.613 3307605.111 0.802 -0.318 0.043 0.132
M516T328 516.300 327.860 5.460 1.133 6372513.846 1635314.251 4920886.372 1874707.328 0.772 -0.373 0.043 0.132
M158T253 158.002 252.530 4.210 1.132 8230106.608 3347126.183 11102542.477 3622391.590 1.349 0.432 0.043 0.132
M610T875_2 610.401 875.240 14.590 1.132 508995.236 170193.994 374348.365 157573.731 0.735 -0.443 0.043 0.132
M615T324_2 615.281 323.920 5.400 1.131 66607.681 59013.105 289060.498 370994.538 4.340 2.118 0.043 0.133
M560T461_2 560.315 461.312 7.690 1.131 3563093.993 723418.781 2923157.720 826380.686 0.820 -0.286 0.043 0.133
M425T400 424.740 400.070 6.670 1.131 556208.356 159044.643 427082.719 155455.432 0.768 -0.381 0.043 0.133
M409T305 409.182 305.465 5.090 1.130 2238548.297 1194718.104 1497024.692 501138.196 0.669 -0.580 0.043 0.133
M414T392 413.763 391.845 6.530 1.130 255995.767 50759.254 201271.793 78545.316 0.786 -0.347 0.043 0.133
M638T872 637.729 872.245 14.540 1.130 333248.577 78992.264 423861.667 132956.004 1.272 0.347 0.043 0.133
M465T418_1 464.835 418.053 6.970 1.130 3751447.505 436499.324 4245573.956 722362.478 1.132 0.179 0.043 0.133
M565T359 565.360 359.367 5.990 1.129 3848056.544 860545.126 3003494.002 1164767.021 0.781 -0.357 0.043 0.133
M951T874 950.606 873.571 14.560 1.129 438278.952 156851.647 317946.091 136880.371 0.725 -0.463 0.043 0.133
M824T400 824.481 400.039 6.670 1.128 4377660.250 970997.773 3495326.550 1165812.737 0.798 -0.325 0.043 0.133
M506T819 506.359 819.201 13.650 1.128 10328296.531 5468081.184 6344195.579 4229887.319 0.614 -0.703 0.043 0.134
M692T374 692.404 374.036 6.230 1.128 17577159.148 3333386.977 14446777.902 4225855.891 0.822 -0.283 0.044 0.134
M673T434_1 672.910 433.949 7.230 1.127 8045914.433 1651576.433 6694728.508 1649908.299 0.832 -0.265 0.044 0.134
M648T479 648.367 479.144 7.990 1.127 600501.292 274245.855 421542.296 150060.120 0.702 -0.510 0.044 0.134
M216T497 216.196 496.752 8.280 1.126 241722.927 110294.366 147442.357 119776.345 0.610 -0.713 0.044 0.134
M611T369 611.483 368.983 6.150 1.126 107784.893 49503.858 172651.575 99261.355 1.602 0.680 0.044 0.134
M532T433 531.826 433.452 7.220 1.125 514097.330 104193.334 422080.863 120061.441 0.821 -0.285 0.044 0.135
M720T374 720.434 374.350 6.240 1.125 1433500.191 188859.100 1256078.648 240711.728 0.876 -0.191 0.044 0.135
M134T229 134.063 228.744 3.810 1.124 1105789.488 789727.762 602419.602 395192.315 0.545 -0.876 0.044 0.135
M430T425 429.888 425.074 7.080 1.124 261800.977 71504.463 199765.095 79995.168 0.763 -0.390 0.044 0.135
M427T400 426.716 400.089 6.670 1.124 748300.915 260501.202 552873.842 218578.240 0.739 -0.437 0.044 0.135
M99T782 99.080 782.222 13.040 1.123 2578919.380 672408.734 2110870.470 466081.293 0.819 -0.289 0.045 0.136
M284T370_2 284.219 369.851 6.160 1.123 244934.448 39599.634 279471.466 44835.493 1.141 0.190 0.045 0.136
M704T870_2 704.129 870.087 14.500 1.123 1036243.895 221797.039 845205.448 245754.093 0.816 -0.294 0.045 0.136
M199T599 199.169 599.220 9.990 1.122 2733325.261 419186.054 3043592.639 342306.802 1.113 0.155 0.045 0.136
M288T681 288.359 680.520 11.340 1.122 320291.149 82817.188 264522.938 52022.861 0.826 -0.276 0.045 0.136
M519T793 519.324 792.828 13.210 1.121 7434629.346 619988.621 6651051.002 1196004.617 0.895 -0.161 0.045 0.136
M106T68 106.050 67.817 1.130 1.121 327985.904 115415.249 242089.686 95744.341 0.738 -0.438 0.045 0.136
M873T468 873.000 467.883 7.800 1.121 857755.955 201882.212 701685.289 182396.810 0.818 -0.290 0.045 0.136
M677T364 677.412 364.215 6.070 1.120 440824.417 52930.375 382203.916 86233.069 0.867 -0.206 0.045 0.137
M690T749 690.229 749.435 12.490 1.120 17665757.330 4193279.458 13573287.326 5711562.428 0.768 -0.380 0.045 0.137
M501T446_2 501.259 445.938 7.430 1.120 228392.518 45174.912 180319.941 69701.970 0.790 -0.341 0.045 0.137
M675T871_1 674.779 871.120 14.520 1.118 1780706.066 380148.868 1488842.356 340482.583 0.836 -0.258 0.046 0.137
M480T443_2 479.945 442.601 7.380 1.118 733026.774 205308.944 576377.377 181427.813 0.786 -0.347 0.046 0.137
M602T876_2 602.070 875.560 14.590 1.117 236414.109 92687.203 170749.183 68652.445 0.722 -0.469 0.046 0.138
M393T406_1 392.749 405.549 6.760 1.116 2614241.510 888296.094 1900869.534 876161.645 0.727 -0.460 0.046 0.139
M714T374 714.335 374.228 6.240 1.115 544548.316 102773.944 452832.862 122527.266 0.832 -0.266 0.046 0.139
M664T387_2 664.269 386.915 6.450 1.115 92827.198 38233.323 130378.080 52958.468 1.405 0.490 0.046 0.139
M158T350 158.002 350.163 5.840 1.115 13641131.223 5256413.903 10073035.557 3467745.888 0.738 -0.437 0.046 0.139
M646T873 645.762 872.505 14.540 1.115 1387011.422 288530.748 1159954.806 274119.767 0.836 -0.258 0.046 0.139
M546T461_3 546.329 461.034 7.680 1.115 979994.534 310127.599 729687.259 309770.766 0.745 -0.425 0.046 0.139
M660T872_1 659.769 872.031 14.530 1.114 2240897.318 395267.042 1845763.107 562487.511 0.824 -0.280 0.046 0.139
M527T348 527.291 347.873 5.800 1.114 112907.025 39184.375 83625.574 33350.948 0.741 -0.433 0.046 0.139
M417T305 417.288 305.462 5.090 1.114 165110.319 81876.532 114284.539 37923.476 0.692 -0.531 0.046 0.139
M565T341 565.280 341.275 5.690 1.114 12409199.145 3153670.667 9785088.255 3341939.844 0.789 -0.343 0.047 0.139
M317T364 316.682 364.047 6.070 1.113 269955.522 117614.131 187373.915 85957.455 0.694 -0.527 0.047 0.139
M751T446 751.388 446.147 7.440 1.113 960748.624 159386.372 839157.534 142435.572 0.873 -0.195 0.047 0.139
M890T266_2 890.226 265.613 4.430 1.112 398182.321 156935.566 289636.838 110438.375 0.727 -0.459 0.047 0.140
M99T378 99.080 378.325 6.310 1.112 8671259.372 1592162.062 7586829.599 1071190.207 0.875 -0.193 0.047 0.140
M663T872_1 663.073 871.511 14.530 1.110 863605.308 179430.484 697073.215 229732.476 0.807 -0.309 0.047 0.141
M617T874 617.395 874.122 14.570 1.110 2813046.392 389152.987 2439139.981 525657.133 0.867 -0.206 0.047 0.141
M537T458_2 536.995 457.640 7.630 1.110 1169070.930 441354.826 879491.297 264219.583 0.752 -0.411 0.047 0.141
M743T450 743.433 450.389 7.510 1.110 2228074.773 724769.241 1679115.511 642363.879 0.754 -0.408 0.047 0.141
M642T411_1 641.732 411.198 6.850 1.110 983959.758 282129.120 1299611.075 472580.140 1.321 0.401 0.047 0.141
M588T369 588.407 369.173 6.150 1.110 1889330.011 587478.674 2418469.211 717993.397 1.280 0.356 0.047 0.141
M441T62 440.724 62.333 1.040 1.109 247435.117 42814.783 185485.469 98807.878 0.750 -0.416 0.048 0.141
M550T458_2 549.981 457.829 7.630 1.108 232473.109 67343.590 176767.381 71318.456 0.760 -0.395 0.048 0.141
M672T434 672.408 433.914 7.230 1.108 14885633.734 2851559.795 12563314.908 2936404.591 0.844 -0.245 0.048 0.141
M199T257 199.169 256.839 4.280 1.108 6644110.825 1333351.994 5391456.874 1746895.046 0.811 -0.301 0.048 0.141
M167T314 167.012 313.737 5.230 1.107 6310150.924 2064261.718 5065836.974 840857.938 0.803 -0.317 0.048 0.142
M621T288_2 621.317 287.586 4.790 1.107 334966.734 163951.459 200577.271 171284.199 0.599 -0.740 0.048 0.142
M809T392 809.488 391.988 6.530 1.106 262088.073 38753.761 218936.774 64820.673 0.835 -0.260 0.048 0.142
M607T749 607.131 748.981 12.480 1.105 6911001.995 1980243.089 5088079.121 2524123.359 0.736 -0.442 0.048 0.142
M618T874_1 617.729 874.028 14.570 1.105 2551395.166 348536.481 2209993.212 488260.941 0.866 -0.207 0.048 0.142
M356T374_2 356.223 374.213 6.240 1.105 154621.078 50659.770 118303.892 40001.553 0.765 -0.386 0.048 0.142
M475T443 474.603 442.717 7.380 1.105 261529.681 87308.451 203476.952 55741.144 0.778 -0.362 0.048 0.142
M486T819 486.294 819.119 13.650 1.104 474705.865 218032.302 316773.242 177030.381 0.667 -0.584 0.049 0.143
M223T610 223.063 610.075 10.170 1.103 1468762.375 399492.000 1180667.115 321403.354 0.804 -0.315 0.049 0.143
M99T280 99.080 279.630 4.660 1.103 13916532.401 4554713.686 10936225.785 2771046.144 0.786 -0.348 0.049 0.143
M338T861 338.341 860.731 14.350 1.101 46076584.052 20909920.772 33137603.800 10215441.503 0.719 -0.476 0.049 0.144
M507T446_2 507.273 446.163 7.440 1.101 688921.661 295239.162 489181.740 201767.858 0.710 -0.494 0.049 0.145
M676T871_3 676.430 870.767 14.510 1.100 1884047.514 357357.362 1576001.039 413094.642 0.837 -0.258 0.049 0.145
M184T314 184.003 313.737 5.230 1.099 1556014.682 434928.413 1881756.331 385644.613 1.209 0.274 0.050 0.145
M632T364 632.354 363.897 6.060 1.099 248237.337 87496.545 182345.076 78557.063 0.735 -0.445 0.050 0.146
M871T468_1 870.523 468.079 7.800 1.098 1153198.695 115755.559 992541.121 257646.688 0.861 -0.216 0.050 0.146
M279T143 279.158 143.266 2.390 1.098 8770248.546 1348259.963 10796785.584 3295312.644 1.231 0.300 0.050 0.146
M195T5 195.065 5.458 0.090 1.098 423817.878 175633.462 549524.103 140629.317 1.297 0.375 0.050 0.146
M738T527_1 737.508 527.166 8.790 1.098 3151633.417 1803107.562 4649054.334 1961706.616 1.475 0.561 0.050 0.146
mz:质核比;rt:保留时间(以秒为单位);rtmin:保留时间(以分钟为单位);*_VIP:VIP值;mean_*:平均值;sd_*:标准差;fold change:倍性变化;log2(FC):倍性变化的log2值;pvalue:统计学p值;FDR:pvalue校正值
以下为差异待鉴定代谢物统计结果:
图:差异代谢物统计柱状图
代谢物上下调关系