差异代谢物筛选
通过对代谢物进行筛选,寻找差异代谢物(biomarker)。相关差异代谢物筛选条件有:
  1. p-value ≤ 0.05 且 VIP ≥ 1[1]
  2. p-value ≤ 0.05 且 fold_change ≥ 1.5或≤0.667[2]
  3. one-way ANOVA p-value ≤ 0.05[3]
  4. two-way ANOVA p-value ≤ 0.05[4]
详细含义:
筛选值 筛选值含义 筛选阈值 备注
p-value 统计学上显著差异 p-value ≤ 0.05
VIP OPLS-DA第一主成分变量重要性值投影 VIP ≥ 1
Fold change 两两组别间倍性变化 fold_change ≥1.5或≤0.667 含量差异较大
one-way ANOVA p-value 一维方差分析 p-value ≤ 0.05 主要用于时间序列,梯度浓度处理等
two-way ANOVA p-value 两因素方差分析 p-value ≤ 0.05 一般为两因素情况,如对照-处理+时间序列样本
本实验采用条件 1+3 进行代谢物筛选,最终获得的差异代谢物见下表:

差异信息汇总信息
差异信息汇总表格;dam_DEG.xlsx (正离子模式)
dam_DEG.xlsx 包含“stats”和“ALL_DEG.xlsx”两个工作簿,其中“stats”统计了各个比对组别差异代谢物的上、下调情况,“ALL_DEG”汇总了所有比对组别的差异代谢物信息。

DOWNLOAD
mz rt rtmin VIP mean_A sd_A mean_B sd_B Fold Change_A/B log2(FC_A/B) p.value FDR
M241T464_1 241.034 464.250 7.740 1.212 8558784.629 22488.928 53413.087 15860.589 160.240 7.324 0.000 0.000
M315T443 315.011 442.584 7.380 1.212 131121265.690 509872.214 40305.380 45771.770 3253.200 11.668 0.000 0.000
M201T451 201.162 450.790 7.510 1.212 32547899.049 142102.907 658040.917 105552.730 49.462 5.628 0.000 0.000
M404T787 404.141 787.048 13.120 1.212 84842697.285 621413.711 21939.307 5237.841 3867.200 11.917 0.000 0.000
M405T787 405.143 787.061 13.120 1.212 15054544.948 106395.427 208318.502 29185.655 72.267 6.175 0.000 0.000
M288T744 288.253 743.510 12.390 1.212 124241434.433 980211.657 104114.231 14614.065 1193.300 10.221 0.000 0.000
M267T416 267.050 416.442 6.940 1.212 31093.171 13741.377 2645382.784 17569.539 0.012 -6.411 0.000 0.000
M248T937 248.201 936.600 15.610 1.212 8197741.405 70296.539 139143.255 5121.378 58.916 5.881 0.000 0.000
M425T425 425.074 425.363 7.090 1.212 127819.061 49289.745 8484311.475 54087.150 0.015 -6.053 0.000 0.000
M255T358 255.120 358.185 5.970 1.212 122525907.265 1014335.480 1680813.977 335538.287 72.897 6.188 0.000 0.000
M374T812 374.131 812.322 13.540 1.212 113813580.111 1007536.271 130745.777 177754.671 870.500 9.766 0.000 0.000
M233T830 233.173 829.739 13.830 1.212 19492888.160 91563.713 1150339.810 143087.006 16.945 4.083 0.000 0.000
M361T606 361.164 605.504 10.090 1.212 59003581.129 554650.383 646887.969 37020.953 91.211 6.511 0.000 0.000
M283T431 283.045 431.419 7.190 1.212 715571.485 6013.140 11520.601 3349.835 62.112 5.957 0.000 0.000
M339T728 339.212 728.267 12.140 1.212 97500488.578 961147.699 198668.008 15869.834 490.770 8.939 0.000 0.000
M330T819 330.205 819.048 13.650 1.212 5183524.363 44459.698 115705.788 23520.946 44.799 5.485 0.000 0.000
M257T482 257.090 481.680 8.030 1.212 31871644.796 261199.308 345290.959 231345.460 92.304 6.528 0.000 0.000
M252T609 252.196 608.567 10.140 1.212 93487323.130 1077210.873 960044.660 256372.517 97.378 6.606 0.000 0.000
M315T620 315.217 619.830 10.330 1.212 39772309.884 479350.966 188161.927 10726.005 211.370 7.724 0.000 0.000
M262T561 262.105 560.751 9.350 1.212 5743952.035 1329625.951 234133874.628 2448059.924 0.025 -5.349 0.000 0.000
M286T568 286.142 568.124 9.470 1.212 154110487.534 1776599.621 8321985.259 136667.216 18.518 4.211 0.000 0.000
M333T620 333.227 619.988 10.330 1.212 63957434.735 788329.534 199231.239 40978.831 321.020 8.326 0.000 0.000
M495T426 495.101 425.680 7.090 1.212 70679.673 20349.166 2727112.383 26126.365 0.026 -5.270 0.000 0.000
M356T926 356.279 925.745 15.430 1.212 9651061.052 99567.691 172303.619 72560.992 56.012 5.808 0.000 0.000
M372T743 372.150 742.625 12.380 1.212 4317629.744 47819.007 206290.486 27595.033 20.930 4.388 0.000 0.000
M129T582 129.054 581.840 9.700 1.212 9320324.080 111177.533 642920.741 35526.448 14.497 3.858 0.000 0.000
M251T509 251.129 508.620 8.480 1.212 67280812.593 697746.970 681583.854 571851.557 98.712 6.625 0.000 0.000
M115T382 115.039 382.043 6.370 1.212 17975047.499 232428.002 758781.601 31947.839 23.689 4.566 0.000 0.000
M613T551 613.200 551.300 9.190 1.212 74201.544 41810.546 6480816.330 79200.786 0.011 -6.449 0.000 0.000
M300T446 300.144 445.759 7.430 1.212 4665744.050 65284.979 18999.396 8427.992 245.570 7.940 0.000 0.000
M340T842 340.284 842.195 14.040 1.212 11182050.949 146708.610 464557.953 44795.139 24.070 4.589 0.000 0.000
M237T703 237.184 702.670 11.710 1.212 227361393.207 3228911.426 1995693.497 313950.571 113.930 6.832 0.000 0.000
M244T450 244.077 449.576 7.490 1.212 7275350.252 99628.140 147082.062 25226.824 49.465 5.628 0.000 0.000
M389T740 389.122 740.131 12.340 1.212 2829056.536 26502.297 327411.240 25792.290 8.641 3.111 0.000 0.000
M272T685 272.162 684.890 11.410 1.212 45752693.047 672470.516 319682.832 23491.282 143.120 7.161 0.000 0.000
M270T735 270.146 735.098 12.250 1.212 74767615.131 1108665.575 124783.720 34768.839 599.180 9.227 0.000 0.000
M254T286 254.108 286.046 4.770 1.212 1245689.651 15258.646 38847.753 9487.248 32.066 5.003 0.000 0.000
M250T509 250.115 509.167 8.490 1.212 94190058.230 1410475.007 727882.052 69288.296 129.400 7.016 0.000 0.000
M349T923 349.219 922.684 15.380 1.212 38514489.766 571572.506 278532.473 98010.438 138.280 7.111 0.000 0.000
M192T756 192.138 755.975 12.600 1.212 15468340.442 227738.202 421539.617 50377.132 36.695 5.197 0.000 0.000
M263T464 263.016 464.092 7.730 1.212 1589275.283 23593.843 17088.379 6549.666 93.003 6.539 0.000 0.000
M377T833 377.142 833.352 13.890 1.212 9341280.712 135678.960 85183.332 51208.389 109.660 6.777 0.000 0.000
M203T407 203.128 406.557 6.780 1.212 26407759.275 407714.673 490802.010 8833.268 53.805 5.750 0.000 0.000
M166T481 166.051 480.967 8.020 1.212 51879443.060 808174.786 887829.328 19220.267 58.434 5.869 0.000 0.000
M358T812 358.103 812.102 13.540 1.212 1107370.401 15103.388 23547.544 8750.611 47.027 5.555 0.000 0.000
M156T395 156.074 394.676 6.580 1.212 10815236.109 156141.555 908079.834 47583.223 11.910 3.574 0.000 0.000
M411T643 411.199 643.341 10.720 1.212 21680270.095 357700.518 18926.531 9948.123 1145.500 10.162 0.000 0.000
M189T524_1 189.090 523.599 8.730 1.212 18419040.051 282174.416 868716.388 68600.307 21.203 4.406 0.000 0.000
M284T198 284.089 197.862 3.300 1.212 42288.850 13858.576 4224625.225 68326.943 0.010 -6.642 0.000 0.000
M393T594 393.284 594.474 9.910 1.212 8740090.632 134158.758 323310.181 46284.737 27.033 4.757 0.000 0.000
M275T411 275.149 410.976 6.850 1.212 5204174.707 86692.208 50617.973 7817.437 102.810 6.684 0.000 0.000
M233T472 233.126 471.912 7.870 1.212 14040564.571 131294.323 1335598.224 174270.106 10.513 3.394 0.000 0.000
M180T740 180.102 739.609 12.330 1.212 3619548.350 51685.292 381703.028 21529.477 9.483 3.245 0.000 0.000
M206T427 206.079 426.587 7.110 1.212 424773469.551 7324901.498 1369544.216 83543.006 310.160 8.277 0.000 0.000
M235T438 235.107 437.863 7.300 1.211 1124947.706 71462.646 50867703.256 860864.410 0.022 -5.499 0.000 0.000
M333T155 333.081 155.060 2.580 1.211 10040.274 7576.224 1290741.883 21177.543 0.008 -7.006 0.000 0.000
M355T692 355.084 691.770 11.530 1.211 1681250.250 18127.693 54370.627 22153.949 30.922 4.951 0.000 0.000
M361T443 361.014 442.953 7.380 1.211 23237.757 9679.985 2327947.916 39786.375 0.010 -6.646 0.000 0.000
M211T320_1 211.077 320.021 5.330 1.211 33946088.762 586437.322 831988.788 68833.765 40.801 5.351 0.000 0.000
M210T500 210.048 500.188 8.340 1.211 1971113.354 34525.293 11902.318 5960.767 165.610 7.372 0.000 0.000
M229T451 229.095 450.514 7.510 1.211 111252212.991 1689612.288 12367309.615 530201.266 8.996 3.169 0.000 0.000
M266T361 266.101 360.941 6.020 1.211 11728004.954 204781.787 175762.094 38480.593 66.727 6.060 0.000 0.000
M385T870 385.221 870.451 14.510 1.211 18894696.009 330160.814 147803.768 78926.788 127.840 6.998 0.000 0.000
M284T327 284.119 326.556 5.440 1.211 310148.708 20906.132 12408338.646 218766.649 0.025 -5.322 0.000 0.000
M228T680 228.196 679.640 11.330 1.211 130296568.693 2367814.579 1105800.910 36551.896 117.830 6.881 0.000 0.000
M244T572 244.130 571.601 9.530 1.211 51093840.021 939533.341 141389.869 62097.890 361.370 8.497 0.000 0.000
M416T569 416.270 568.545 9.480 1.211 242555.096 12155.865 1286208.287 15133.845 0.189 -2.407 0.000 0.000
M307T818 307.283 817.997 13.630 1.211 26254128.839 475473.753 387727.085 83157.303 67.713 6.081 0.000 0.000
M398T542 398.168 542.370 9.040 1.211 35006276.242 658208.599 52984.975 23233.010 660.680 9.368 0.000 0.000
M417T543 417.180 542.526 9.040 1.211 929435.861 14402.918 19592.857 9436.939 47.437 5.568 0.000 0.000
M180T735 180.138 735.496 12.260 1.211 8950691.436 155898.188 444907.728 41534.031 20.118 4.330 0.000 0.000
M192T379 192.063 379.094 6.320 1.211 525488773.706 9948008.543 1054823.627 95158.068 498.180 8.960 0.000 0.000
M313T362 313.162 362.260 6.040 1.211 36741300.777 692738.841 258681.437 27640.205 142.030 7.150 0.000 0.000
M253T609 253.199 608.912 10.150 1.211 15205836.678 230691.924 1355628.657 129245.438 11.217 3.488 0.000 0.000
M230T675 230.081 674.726 11.250 1.211 195156.278 45429.359 364681901.912 6984724.291 0.001 -10.868 0.000 0.000
M275T711 275.091 710.832 11.850 1.211 65243007.820 1240508.653 403479.904 87564.043 161.700 7.337 0.000 0.000
M415T543 415.174 542.505 9.040 1.211 40428392.693 769337.610 131296.126 78671.147 307.920 8.266 0.000 0.000
M208T397 208.032 397.380 6.620 1.211 17207670.218 328220.136 220397.481 9614.187 78.076 6.287 0.000 0.000
M249T418 249.133 418.224 6.970 1.211 34170784.708 649040.035 538600.778 45199.744 63.444 5.987 0.000 0.000
M499T676 499.207 675.958 11.270 1.211 107906.164 49391.606 3312062.305 38423.716 0.033 -4.940 0.000 0.000
M274T483 274.141 483.477 8.060 1.211 3420898.449 63726.972 102083.364 12831.413 33.511 5.067 0.000 0.000
M236T858 236.201 858.461 14.310 1.211 106609917.564 1648811.087 2753640.842 1199553.246 38.716 5.275 0.000 0.000
M357T780 357.167 780.248 13.000 1.211 82874016.405 1610075.592 318247.857 237585.727 260.410 8.025 0.000 0.000
M214T708 214.216 708.168 11.800 1.211 25852181.516 506342.878 212029.012 25250.345 121.930 6.930 0.000 0.000
M293T540_2 293.137 539.796 9.000 1.211 32217408.841 353839.308 1031919.880 508166.185 31.221 4.964 0.000 0.000
M421T593 421.148 592.677 9.880 1.211 21177413.868 422222.330 72814.859 14329.227 290.840 8.184 0.000 0.000
M201T345 201.124 345.235 5.750 1.211 15149954.500 282807.892 315469.451 90864.341 48.024 5.586 0.000 0.000
M234T649 234.185 649.205 10.820 1.211 19058071.241 358999.937 713416.626 79678.879 26.714 4.739 0.000 0.000
M350T849 350.232 849.302 14.160 1.211 415151690.855 8342408.465 440860.201 70504.378 941.690 9.879 0.000 0.000
M239T501 239.125 500.802 8.350 1.211 1518943438.826 30452839.340 4380587.066 2042588.996 346.740 8.438 0.000 0.000
M441T543 441.373 543.499 9.060 1.211 2747732.907 49310.438 35988.309 23969.515 76.351 6.255 0.000 0.000
M174T352 174.053 352.317 5.870 1.211 5727799.015 105667.273 453789.119 16164.889 12.622 3.658 0.000 0.000
M247T569 247.152 568.539 9.480 1.211 14177800.845 266985.139 356254.866 86426.890 39.797 5.315 0.000 0.000
M433T601 433.188 601.434 10.020 1.211 5648706.542 114195.349 34999.610 7902.475 161.390 7.334 0.000 0.000
M272T698 272.162 698.107 11.640 1.211 78833127.499 1605224.261 427270.694 21062.075 184.500 7.527 0.000 0.000
M216T738 216.232 738.404 12.310 1.211 32770359.774 670357.328 88339.937 17044.038 370.960 8.535 0.000 0.000
M318T713 318.236 712.518 11.880 1.211 16120011.291 325038.650 120457.007 47055.621 133.820 7.064 0.000 0.000
M283T734 283.238 734.482 12.240 1.211 52798124.538 1072120.364 543996.049 50509.709 97.056 6.601 0.000 0.000
M325T789 325.164 789.252 13.150 1.211 10156057.158 195445.083 261692.564 60316.532 38.809 5.278 0.000 0.000
M260T566 260.201 566.283 9.440 1.211 1943941.053 38015.701 20429.091 12238.343 95.156 6.572 0.000 0.000
M423T805_2 423.310 804.899 13.410 1.211 39408886.785 217459.175 6463597.640 659937.729 6.097 2.608 0.000 0.000
M177T658 177.055 658.443 10.970 1.211 14496967.214 284549.912 1078755.642 9684.353 13.439 3.748 0.000 0.000
M288T455 288.180 454.813 7.580 1.211 5919759.168 123441.436 78631.177 15090.515 75.285 6.234 0.000 0.000
M261T713 261.227 712.839 11.880 1.211 36554217.405 770725.824 503982.087 39429.586 72.531 6.181 0.000 0.000
M385T542 385.164 542.318 9.040 1.211 11229126.851 238223.561 65907.147 24880.525 170.380 7.413 0.000 0.000
M367T542 367.153 542.203 9.040 1.211 4434851.819 76756.863 301523.908 44835.632 14.708 3.878 0.000 0.000
M210T395_1 210.053 394.552 6.580 1.211 14704042.707 298614.786 623967.493 52019.281 23.565 4.559 0.000 0.000
M281T851 281.174 850.566 14.180 1.211 19948017.734 243020.103 2277135.087 295266.776 8.760 3.131 0.000 0.000
M257T325 257.136 325.425 5.420 1.211 188889780.594 4097082.286 503209.225 46142.455 375.370 8.552 0.000 0.000
M258T795 258.279 795.240 13.250 1.211 65232596.208 1282207.551 5364876.705 251139.008 12.159 3.604 0.000 0.000
M417T428 417.152 427.702 7.130 1.211 12076362.912 255970.968 310300.746 29792.413 38.918 5.282 0.000 0.000
M287T646 287.125 646.287 10.770 1.211 48336920.724 869722.678 1589650.779 540449.734 30.407 4.926 0.000 0.000
M291T396 291.006 396.000 6.600 1.211 537781.762 3267.259 30135.777 10650.484 17.845 4.157 0.000 0.000
M318T588 318.069 588.388 9.810 1.211 14983697.671 327816.174 58562.901 8007.334 255.860 7.999 0.000 0.000
M233T522 233.117 521.707 8.700 1.211 23370824.390 507739.348 267099.396 19703.281 87.499 6.451 0.000 0.000
M189T763 189.091 762.831 12.710 1.211 1185908.331 110648.783 22291943.283 452946.602 0.053 -4.232 0.000 0.000
M316T321 315.994 320.810 5.350 1.211 24613.886 13420.022 1729376.973 35263.035 0.014 -6.135 0.000 0.000
M498T802 498.256 801.850 13.360 1.211 34556536.703 702250.916 387990.330 287109.088 89.065 6.477 0.000 0.000
M454T426 454.074 425.675 7.090 1.211 219732.984 48363.361 2763694.770 29627.061 0.080 -3.653 0.000 0.000
M125T732 125.097 731.880 12.200 1.211 73850600.177 1574315.620 3008214.936 234336.105 24.550 4.618 0.000 0.000
M359T623 359.148 623.434 10.390 1.211 183586798.660 4123707.772 210200.208 150029.904 873.390 9.771 0.000 0.000
M243T533 243.065 533.168 8.890 1.211 33851370.417 749515.908 262180.668 102584.201 129.110 7.013 0.000 0.000
M280T501_1 280.157 501.401 8.360 1.211 86198344.179 1851100.192 3600410.615 247337.744 23.941 4.581 0.000 0.000
M275T413 275.100 413.424 6.890 1.211 27096048.216 613937.932 28338.147 18825.270 956.170 9.901 0.000 0.000
M183T717 183.194 716.643 11.940 1.211 18369415.208 410738.363 267646.743 12908.833 68.633 6.101 0.000 0.000
M278T677 278.175 676.714 11.280 1.211 41537395.793 858961.052 2419036.858 227375.075 17.171 4.102 0.000 0.000
M321T155 321.024 155.050 2.580 1.211 54767.183 16056.458 1745711.288 34903.455 0.031 -4.994 0.000 0.000
M220T925 220.178 924.692 15.410 1.211 4492921.726 90441.784 234754.607 34937.512 19.139 4.258 0.000 0.000
M301T518 301.034 518.262 8.640 1.211 8455645.305 177628.325 300271.955 54986.805 28.160 4.816 0.000 0.000
M374T591 374.087 591.051 9.850 1.211 2572030.729 53760.505 100529.663 19168.939 25.585 4.677 0.000 0.000
M341T873 341.232 872.872 14.550 1.211 222651241.592 5132597.676 572162.423 71984.738 389.140 8.604 0.000 0.000
M238T399 238.105 399.060 6.650 1.211 190093486.029 4061519.701 9886699.813 930680.500 19.227 4.265 0.000 0.000
M297T620 297.206 619.840 10.330 1.211 29801989.672 668931.114 921564.211 41097.303 32.338 5.015 0.000 0.000
M286T394 286.098 393.963 6.570 1.211 3625708.145 78922.388 36521.564 27203.332 99.276 6.633 0.000 0.000
M105T80 105.004 80.120 1.340 1.211 34425664.676 667068.685 3189456.177 291126.528 10.794 3.432 0.000 0.000
M325T541 325.128 541.369 9.020 1.211 11149490.543 255078.055 118048.573 36524.533 94.448 6.561 0.000 0.000
M219T610 219.102 610.363 10.170 1.211 407342538.515 8658185.198 11476456.030 3414303.661 35.494 5.149 0.000 0.000
M339T617 339.199 617.431 10.290 1.211 7812681.680 177516.903 201009.810 27557.303 38.867 5.280 0.000 0.000
M257T269 257.063 269.337 4.490 1.211 91333986.004 2149016.367 384421.903 18825.977 237.590 7.892 0.000 0.000
M267T750 267.215 750.382 12.510 1.211 86043285.318 2028203.191 713230.966 58556.839 120.640 6.915 0.000 0.000
M242T717_2 242.211 717.374 11.960 1.211 2217121826.266 52929436.994 5508353.675 1105210.196 402.500 8.653 0.000 0.000
M300T475 300.062 474.834 7.910 1.211 2173035.959 49774.737 23134.807 13097.447 93.929 6.553 0.000 0.000
M337T246 337.069 245.755 4.100 1.211 20192.287 12907.169 962863.802 18735.088 0.021 -5.575 0.000 0.000
M83T80_1 82.538 80.146 1.340 1.211 334865578.666 4997858.191 48669385.121 4839512.383 6.880 2.782 0.000 0.000
M262T369 262.071 369.142 6.150 1.211 10307836.096 241510.600 363267.604 14020.991 28.375 4.827 0.000 0.000
M226T258 226.046 258.158 4.300 1.211 33318316.309 808604.743 440100.545 34851.896 75.706 6.242 0.000 0.000
M299T796 299.164 796.264 13.270 1.211 4480699.887 99058.983 409360.371 15797.428 10.946 3.452 0.000 0.000
M265T321 264.967 320.611 5.340 1.211 153735.324 5546.489 3000228.256 69932.175 0.051 -4.287 0.000 0.000
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M157T335 157.013 334.775 5.580 1.005 2257834.577 816009.572 730044.814 199420.494 3.093 1.629 0.011 0.018
M144T379 144.102 378.755 6.310 1.005 4706033.579 962554.360 2711727.029 525586.544 1.735 0.795 0.011 0.018
M234T1005 234.132 1004.805 16.750 1.005 28904566.202 11035739.972 5948444.798 6134573.669 4.859 2.281 0.011 0.018
M238T358_1 238.069 358.113 5.970 1.005 13047040.007 6704777.836 856229.515 91490.095 15.238 3.930 0.011 0.018
M267T753 267.122 753.490 12.560 1.005 7122389.329 3219453.216 1241473.865 317441.978 5.737 2.520 0.011 0.018
M200T317 200.184 316.517 5.280 1.005 680599.456 161454.182 1085137.643 153184.177 0.627 -0.673 0.011 0.018
M231T709 231.138 708.527 11.810 1.005 48564426.031 25553053.806 2093433.218 844059.615 23.198 4.536 0.011 0.018
M338T474 338.122 474.482 7.910 1.005 1877358.291 594251.611 450766.080 513165.460 4.165 2.058 0.011 0.018
M325T977 325.293 977.369 16.290 1.005 1743365.707 508363.764 785570.737 139551.433 2.219 1.150 0.011 0.018
M523T600 523.195 599.915 10.000 1.005 1668499.917 524069.127 401748.171 459929.554 4.153 2.054 0.011 0.018
M565T928_1 565.334 927.624 15.460 1.005 345143.406 144299.658 955013.906 303103.229 0.361 -1.468 0.011 0.018
M690T922_2 690.475 921.557 15.360 1.005 2413034.337 2770858.512 13436779.294 5398421.641 0.180 -2.477 0.011 0.018
M297T932 297.315 932.397 15.540 1.005 725556.873 193271.554 1459275.969 354703.447 0.497 -1.008 0.011 0.018
M354T800 354.167 799.631 13.330 1.005 1800485.431 682154.849 362445.475 402348.993 4.968 2.313 0.011 0.018
M328T615_2 328.248 615.297 10.250 1.005 7386879.150 2890632.629 1903807.625 873725.261 3.880 1.956 0.011 0.018
M221T373 221.117 372.945 6.220 1.005 10662691.014 5276623.877 1028510.735 560210.945 10.367 3.374 0.011 0.018
M235T385 235.069 385.204 6.420 1.005 1099168.392 493758.273 202425.782 15455.097 5.430 2.441 0.011 0.018
M545T522_2 545.212 521.707 8.700 1.004 85586761.560 33383096.301 16189835.107 18653387.051 5.287 2.402 0.011 0.018
M297T397 297.155 396.748 6.610 1.004 720712.114 42745.077 823367.976 37054.454 0.875 -0.192 0.011 0.018
M252T408 252.196 408.236 6.800 1.004 5321652.201 2535729.936 677338.609 347447.226 7.857 2.974 0.011 0.018
M607T977_1 607.241 976.999 16.280 1.004 49719717.488 22551266.999 6102223.275 8332736.091 8.148 3.026 0.011 0.018
M561T882_1 561.469 881.952 14.700 1.004 6818832.572 3030737.729 1313167.013 170713.104 5.193 2.377 0.011 0.018
M535T578 535.156 578.200 9.640 1.004 3782328.640 1138015.749 1236808.513 821551.808 3.058 1.613 0.011 0.018
M256T842 256.300 842.057 14.030 1.004 15703099.874 1637489.573 38284030.909 12344185.652 0.410 -1.286 0.011 0.018
M484T850 484.414 849.967 14.170 1.004 20045305.849 6668937.198 5755503.791 4198847.080 3.483 1.800 0.011 0.018
M305T921 305.230 921.244 15.350 1.004 4010450.742 2102990.764 196082.885 51044.077 20.453 4.354 0.011 0.018
M431T705 431.157 705.028 11.750 1.004 510168.007 81854.081 2753572.801 1234594.137 0.185 -2.432 0.011 0.018
M273T759 273.262 759.141 12.650 1.004 18839129.983 8897449.015 2600298.804 1039278.497 7.245 2.857 0.011 0.018
M196T201 196.059 201.173 3.350 1.004 38287185.618 20423987.156 1270574.629 148499.036 30.134 4.913 0.011 0.018
M421T428 421.241 427.820 7.130 1.004 2947529.832 590552.424 1868403.436 76353.596 1.578 0.658 0.011 0.018
M519T834 519.426 834.000 13.900 1.004 16477822.453 8696498.902 694064.327 483340.862 23.741 4.569 0.011 0.018
M318T789_2 318.451 789.466 13.160 1.004 1108030.295 163979.754 246373.605 446334.732 4.497 2.169 0.011 0.018
M322T933 322.237 933.043 15.550 1.004 21540016.340 11562677.734 587380.044 118174.415 36.671 5.197 0.011 0.018
M163T511 163.148 510.911 8.520 1.004 7400423.622 3397417.719 1245434.951 22035.212 5.942 2.571 0.011 0.018
M242T573 242.139 573.371 9.560 1.004 7813984.883 3298996.204 1782588.954 448059.521 4.383 2.132 0.011 0.018
M135T513 135.080 513.447 8.560 1.004 15101622.423 7134511.962 2142960.060 537716.286 7.047 2.817 0.011 0.018
M307T660 307.263 659.520 10.990 1.004 3753448.783 1541972.841 771148.988 577561.826 4.867 2.283 0.011 0.018
M245T470 245.165 470.451 7.840 1.004 1040161.267 406006.250 304093.713 22122.489 3.421 1.774 0.011 0.018
M770T813_1 770.318 813.245 13.550 1.004 4500925.046 1696611.170 1429143.782 30159.666 3.149 1.655 0.011 0.018
M469T911 469.329 910.617 15.180 1.004 15490980.390 3629977.268 7275135.192 2724388.055 2.129 1.090 0.011 0.018
M577T558_1 577.119 558.380 9.310 1.004 131584577.955 71798290.098 1625994.629 749800.029 80.926 6.338 0.011 0.018
M137T110_1 137.046 109.903 1.830 1.004 1016390.922 231037.169 1578824.228 207873.030 0.644 -0.635 0.011 0.018
M179T695 179.107 695.456 11.590 1.004 17591865.063 8648095.567 1938261.308 190618.813 9.076 3.182 0.011 0.018
M223T534 223.144 534.137 8.900 1.003 6174704.764 1743082.727 1516340.972 1894805.832 4.072 2.026 0.011 0.018
M415T642 415.100 642.132 10.700 1.003 887591.616 118968.291 345187.695 275173.655 2.571 1.363 0.011 0.018
M205T512 205.123 511.599 8.530 1.003 19470134.972 8578563.310 3936103.785 383924.917 4.947 2.306 0.011 0.018
M214T778 214.123 777.800 12.960 1.003 5737055.976 1472570.369 2722547.343 780341.036 2.107 1.075 0.011 0.018
M226T428 226.108 428.431 7.140 1.003 15296152.875 7844019.635 1096158.745 324420.734 13.954 3.803 0.011 0.018
M285T164 285.058 164.018 2.730 1.003 32659.695 13862.135 7188.664 2482.737 4.543 2.184 0.011 0.018
M240T340 240.063 340.494 5.670 1.003 5084085.569 414200.895 3981429.849 447629.828 1.277 0.353 0.011 0.018
M274T506 274.076 506.214 8.440 1.003 13554334.140 7039983.287 824258.989 118161.981 16.444 4.040 0.011 0.018
M337T843 337.274 842.769 14.050 1.003 7150374.599 1259981.399 2573020.585 2196518.521 2.779 1.475 0.011 0.018
M255T706 255.194 705.933 11.770 1.003 9448265.024 3479081.544 2854284.000 1097295.460 3.310 1.727 0.011 0.018
M490T86 489.803 86.415 1.440 1.003 155848.057 30833.832 35689.677 58899.230 4.367 2.127 0.011 0.018
M224T88 223.876 88.231 1.470 1.003 7631529.052 232032.075 8382168.955 344490.704 0.910 -0.135 0.011 0.018
M249T674_2 249.196 674.249 11.240 1.003 1827384.755 785293.307 403806.482 61663.036 4.525 2.178 0.011 0.018
M209T571 209.081 570.905 9.520 1.003 77799892.254 41965185.859 1898796.472 1739644.514 40.973 5.357 0.011 0.018
M396T635 396.272 635.426 10.590 1.003 9419209.446 1096133.561 2016498.113 3947425.848 4.671 2.224 0.011 0.018
M409T992 409.331 991.633 16.530 1.003 6065171.300 553935.282 3056842.384 1570050.479 1.984 0.989 0.011 0.018
M354T692 354.105 691.913 11.530 1.003 2247280.886 384394.671 686543.836 773517.145 3.273 1.711 0.011 0.018
M387T916 387.272 915.837 15.260 1.003 2882917.294 1226903.471 600958.005 299595.666 4.797 2.262 0.011 0.018
M326T581 326.232 580.677 9.680 1.003 1474855.918 760683.157 99660.746 25685.449 14.799 3.887 0.011 0.018
M140T990 140.022 989.624 16.490 1.003 5049177.124 2523981.985 11743588.104 2712874.647 0.430 -1.218 0.011 0.018
M221T555 221.107 555.361 9.260 1.003 2878102.225 1076292.362 775799.182 442398.911 3.710 1.891 0.011 0.018
M266T646 266.146 646.274 10.770 1.003 2451287.579 1305355.829 93055.841 8248.122 26.342 4.719 0.011 0.018
M277T643_1 277.071 643.239 10.720 1.003 1013322.698 562598.192 2325606.350 459517.666 0.436 -1.199 0.011 0.018
M271T536 271.097 535.915 8.930 1.003 23853607.384 12773277.946 777058.796 215453.692 30.697 4.940 0.011 0.018
M207T677 207.138 676.818 11.280 1.003 21996704.050 6607957.137 7218704.000 4824675.070 3.047 1.607 0.011 0.018
M278T833 278.248 833.339 13.890 1.003 27450965.135 11513454.518 6405310.745 1793314.080 4.286 2.099 0.011 0.018
M215T591 215.031 591.448 9.860 1.003 1076305.701 490877.612 188957.873 20578.826 5.696 2.510 0.011 0.018
M139T431 139.040 430.790 7.180 1.003 33797658.359 13052433.195 10218222.290 376225.359 3.308 1.726 0.011 0.018
M229T434 229.107 434.341 7.240 1.003 6508665.807 2836285.803 1228342.495 715662.003 5.299 2.406 0.011 0.018
M623T606 623.208 606.477 10.110 1.003 3463216.619 1894015.112 44287.339 14165.121 78.199 6.289 0.011 0.018
M745T89 744.640 88.841 1.480 1.003 230394.931 70086.534 61200.161 62247.952 3.765 1.913 0.011 0.018
M186T419 186.149 419.357 6.990 1.003 3402485.350 1375314.588 885346.282 231252.514 3.843 1.942 0.011 0.018
M313T762 313.237 762.360 12.710 1.003 9604861.148 1704988.833 5338281.381 1637699.666 1.799 0.847 0.011 0.018
M421T770 421.292 769.527 12.830 1.003 8758491.916 373051.691 4340994.616 2419288.073 2.018 1.013 0.011 0.018
M449T797 449.300 797.241 13.290 1.003 3649314.083 1266878.719 1299484.801 300937.307 2.808 1.490 0.011 0.018
M295T802_2 295.173 802.021 13.370 1.003 1650330.801 527562.072 602334.806 243051.630 2.740 1.454 0.011 0.018
M747T437 747.186 437.330 7.290 1.003 2045724.027 686091.951 804167.565 53195.682 2.544 1.347 0.011 0.018
M302T765 302.268 765.153 12.750 1.003 1523366.493 174684.301 1931922.485 144129.767 0.789 -0.343 0.011 0.018
M469T733 469.319 733.276 12.220 1.003 293606.111 52022.508 27343400.194 14995819.610 0.011 -6.541 0.011 0.018
M164T523 164.143 522.972 8.720 1.002 2606186.442 431865.603 1628520.823 327588.750 1.600 0.678 0.011 0.018
M257T218 257.100 218.352 3.640 1.002 4494472.328 2028300.136 829653.706 123658.957 5.417 2.438 0.011 0.018
M336T567 336.146 567.292 9.450 1.002 1252345.420 333721.603 338096.223 381630.281 3.704 1.889 0.011 0.018
M195T474 195.065 474.016 7.900 1.002 5086646.306 1063003.022 2143776.978 1238246.451 2.373 1.247 0.011 0.018
M481T960 481.256 959.677 15.990 1.002 3559716.730 1746791.198 385387.161 220436.035 9.237 3.207 0.011 0.018
M331T411_2 331.208 411.103 6.850 1.002 250238.376 63521.543 133393.861 12911.402 1.876 0.908 0.011 0.018
M292T848 292.196 847.506 14.130 1.002 17552526.126 9221941.772 917671.003 406330.677 19.127 4.258 0.011 0.018
M241T349 241.105 348.967 5.820 1.002 8399507.484 2302934.441 4234810.321 197988.704 1.983 0.988 0.011 0.018
M375T994 375.304 994.440 16.570 1.002 3603252.393 1478494.937 832069.615 426635.650 4.330 2.115 0.011 0.018
M430T859 430.352 858.538 14.310 1.002 7534043.558 2142672.618 2617342.717 1692849.914 2.878 1.525 0.011 0.018
M320T821 320.191 821.482 13.690 1.002 3600229.909 754922.280 1496223.530 891983.334 2.406 1.267 0.011 0.018
M529T724 529.335 724.480 12.070 1.002 909738.474 445220.512 105627.508 38838.320 8.613 3.107 0.011 0.018
M486T800 486.328 799.739 13.330 1.002 618743.218 1128364.835 4983574.597 2147719.433 0.124 -3.010 0.011 0.018
M211T407 211.060 406.779 6.780 1.002 2212854.250 837452.872 3996046.865 530448.401 0.554 -0.853 0.011 0.018
M253T771_2 253.179 771.229 12.850 1.001 28902979.203 14482645.850 2862782.131 148585.124 10.096 3.336 0.011 0.018
M381T926 381.282 925.739 15.430 1.001 7765894.616 3588062.004 1290979.668 309592.950 6.016 2.589 0.011 0.018
M414T695 414.370 694.834 11.580 1.001 7980275.127 2812652.084 2855969.808 464694.254 2.794 1.482 0.011 0.018
M585T979 585.373 978.949 16.320 1.001 6076750.393 3015476.118 636172.688 261671.804 9.552 3.256 0.011 0.018
M336T665 336.216 665.490 11.090 1.001 18820069.631 10415764.444 102279.579 39695.743 184.010 7.524 0.011 0.019
M251T483 251.089 482.989 8.050 1.001 8981855.598 4229046.521 1378880.628 159976.902 6.514 2.704 0.011 0.019
M228T662_2 228.159 661.901 11.030 1.001 5572108.280 2418741.308 1226777.692 26632.132 4.542 2.183 0.011 0.019
M390T914 390.263 914.064 15.230 1.001 8960274.852 4902244.324 152225.755 129436.661 58.862 5.879 0.011 0.019
M191T731 191.106 730.666 12.180 1.001 17390784.114 7289693.328 4258900.911 575601.526 4.083 2.030 0.011 0.019
M227T787 227.248 787.058 13.120 1.001 2240592.761 1127582.784 213767.311 49241.282 10.481 3.390 0.011 0.019
M301T805 301.070 805.348 13.420 1.001 13222900.348 5968704.286 2500913.036 156997.043 5.287 2.402 0.011 0.019
M462T978_2 462.430 978.023 16.300 1.001 1764380.306 794454.851 7241248.493 2944939.640 0.244 -2.037 0.011 0.019
M225T356 225.074 355.941 5.930 1.001 4378116.111 2053426.078 659761.803 277689.615 6.636 2.730 0.012 0.019
M245T849 245.154 849.389 14.160 1.001 8045718.813 3840134.406 1143977.306 215712.062 7.033 2.814 0.012 0.019
M147T843_2 147.116 843.025 14.050 1.001 20197907.716 2613868.998 7413084.203 6628198.223 2.725 1.446 0.012 0.019
M330T612 330.074 611.952 10.200 1.001 695799.987 355005.795 58548.462 12042.698 11.884 3.571 0.012 0.019
M480T847 480.405 847.148 14.120 1.001 16048023.042 7710108.921 1879088.569 1728879.975 8.540 3.094 0.012 0.019
M355T627 355.118 627.025 10.450 1.001 50427952.617 27826762.257 532734.826 481377.113 94.659 6.565 0.012 0.019
M329T641 329.029 641.405 10.690 1.000 5607926.461 1098904.140 3487992.283 437452.281 1.608 0.685 0.012 0.019
M138T495 138.091 495.435 8.260 1.000 4443662.357 1813832.917 1076664.826 489860.239 4.127 2.045 0.012 0.019
M847T628_2 847.194 627.632 10.460 1.000 1975348.653 744320.439 520086.480 324970.580 3.798 1.925 0.012 0.019
M145T107 145.086 106.991 1.780 1.000 2004666.505 395433.730 2782278.845 178827.521 0.721 -0.473 0.012 0.019
M396T602 396.272 601.721 10.030 1.000 8879546.518 3884987.703 1908106.082 213201.015 4.654 2.218 0.012 0.019
M294T96 294.213 95.920 1.600 1.000 637583.069 329234.742 46169.378 25593.925 13.810 3.788 0.012 0.019
M333T779 333.168 779.324 12.990 1.000 14621917.232 4770421.736 4899401.082 2592254.691 2.984 1.578 0.012 0.019
M204T460 204.138 459.839 7.660 1.000 4128639.686 1759252.646 858815.274 489635.116 4.807 2.265 0.012 0.019
M629T824 628.516 824.221 13.740 1.000 4056075.018 629937.728 2020876.697 946724.420 2.007 1.005 0.012 0.019
mz:质核比;rt:保留时间(以秒为单位);rtmin:保留时间(以分钟为单位);*_VIP:VIP值;mean_*:平均值;sd_*:标准差;fold change:倍性变化;log2(FC):倍性变化的log2值;pvalue:统计学p值;FDR:pvalue校正值
以下为差异待鉴定代谢物统计结果:
图:差异代谢物统计柱状图
代谢物上下调关系